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H. Jacobs · SciRah

Researcher profile · Semantic Scholar

H. Jacobs

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H. Jacobs — researcher profile on SciRah

h-index: 50
Works: 198
Citations: 15K

Most-cited papers

Repurposing mitochondria from ATP production to ROS generation drives a pro-inflammatory phenotype in macrophages that depends on succinate oxidation by complex II
E. Mills, B. Kelly, A. Logan, Ana S. H. Costa +16 more
2016Cell2,112 citations Open access
Semantic Scholar
Mitochondria are physiologically maintained at close to 50 °C
D. Chrétien, P. Bénit, Hyung-Ho Ha, S. Keipert +6 more
2017bioRxiv402 citations Open access
Semantic Scholar
Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation
L. Billingham, J. Stoolman, K. Vasan, Arianne E. Rodriguez +8 more
2022Nature Immunology321 citations Open access
Semantic Scholar
Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter
A. Rubio-Cosials, J. Sydow, N. Jiménez-Menéndez, P. Fernández-Millán +5 more
2011Nature Structural &Molecular Biology202 citations Open access
Semantic Scholar
Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation.
Daniel J M Fernández-Ayala, A. Sanz, S. Vartiainen, Kia Kemppainen +9 more
2009Cell Metabolism187 citations Open access
Semantic Scholar
Stabilization of Hypoxia-inducible Factor-1α Protein in Hypoxia Occurs Independently of Mitochondrial Reactive Oxygen Species Production*
Liu-Chua Yee, E. Dufour, E. Dassa, P. Rustin +3 more
2010Journal of Biological Chemistry183 citations Open access
Semantic Scholar
Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction
A. Sanz, Mikko Soikkeli, M. Portero-Otín, A. Wilson +19 more
2010Proceedings of the National Academy of Sciences of the United States of America151 citations Open access
Semantic Scholar
Human Heart Mitochondrial DNA Is Organized in Complex Catenated Networks Containing Abundant Four-way Junctions and Replication Forks
J. Pohjoismäki, Steffi Goffart, H. Tyynismaa, S. Willcox +7 more
2009Journal of Biological Chemistry132 citations Open access
Semantic Scholar
A mitochondrial ribosomal and RNA decay pathway blocks cell proliferation.
Uwe Richter, Taina Lahtinen, Paula Marttinen, M. Myöhänen +6 more
2013Current Biology122 citations Open access
Semantic Scholar
Alternative Oxidase Expression in the Mouse Enables Bypassing Cytochrome c Oxidase Blockade and Limits Mitochondrial ROS Overproduction
R. El-Khoury, E. Dufour, Malgorzata Rak, N. Ramanantsoa +9 more
2013PLoS Genetics120 citations Open access
Semantic Scholar
Mitochondrial DNA replication proceeds via a ‘bootlace’ mechanism involving the incorporation of processed transcripts
A. Reyes, L. Kazak, Stuart R. Wood, T. Yasukawa +2 more
2013Nucleic Acids Research115 citations Open access
Semantic Scholar
Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy
S. Dogan, R. Cerutti, Cristiane Benincá, Gloria Brea-Calvo +4 more
2018Cell Metabolism91 citations Open access
Semantic Scholar
Gene Expression in a Drosophila Model of Mitochondrial Disease
Daniel J M Fernández-Ayala, Shanjun Chen, E. Kemppainen, K. O'Dell +1 more
2010PLoS ONE74 citations Open access
Semantic Scholar
Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology
M. Szibor, Praveen K Dhandapani, E. Dufour, Kira M. Holmström +16 more
2017Disease Models & Mechanisms69 citations Open access
Semantic Scholar
Alternative oxidase‐mediated respiration prevents lethal mitochondrial cardiomyopathy
Jayasimman Rajendran, J. Purhonen, Saara Tegelberg, Olli-Pekka Smolander +11 more
2018EMBO Molecular Medicine65 citations Open access
Semantic Scholar
Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency
Kia Kemppainen, Juho Rinne, A. Sriram, Matti Lakanmaa +7 more
2013Human Molecular Genetics65 citations Open access
Semantic Scholar
Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing
N. Sommer, N. Alebrahimdehkordi, O. Pak, F. Knoepp +20 more
2020Science Advances62 citations Open access
Semantic Scholar
Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila.
Dickon M. Humphrey, R. Parsons, Zoe N. Ludlow, T. Riemensperger +5 more
2012Human Molecular Genetics58 citations Open access
Semantic Scholar
Glucose Modulates Respiratory Complex I Activity in Response to Acute Mitochondrial Dysfunction
G. Cannino, R. El-Khoury, Marja Pirinen, Bettina Hutz +3 more
2012Journal of Biological Chemistry53 citations Open access
Semantic Scholar
Respiratory chain alternative enzymes as tools to better understand and counteract respiratory chain deficiencies in human cells and animals.
P. Rustin, H. Jacobs
2009Physiologia Plantarum : An International Journal for Plant Biology52 citations
Semantic Scholar
Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat
N. Jiménez-Menéndez, P. Fernández-Millán, A. Rubio-Cosials, Carme Arnan +6 more
2010Nature Structural &Molecular Biology51 citations Open access
Semantic Scholar
Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase
Atsushi Fukuoh, G. Cannino, M. Gerards, S. Buckley +6 more
2014Molecular Systems Biology49 citations Open access
Semantic Scholar
Alternative Oxidase Attenuates Cigarette Smoke–induced Lung Dysfunction and Tissue Damage
L. Giordano, Antoine Farnham, Praveen K Dhandapani, L. Salminen +12 more
2019American Journal of Respiratory Cell and Molecular Biology47 citations Open access
Semantic Scholar
Developmental and Pathological Changes in the Human Cardiac Muscle Mitochondrial DNA Organization, Replication and Copy Number
J. Pohjoismäki, Steffi Goffart, R. Taylor, D. Turnbull +3 more
2010PLoS ONE47 citations Open access
Semantic Scholar
Mitochondrial transcription termination factor 1 directs polar replication fork pausing
Yong-Hong Shi, Viktor Posse, Xuefeng Zhu, Anne K. Hyvärinen +3 more
2016Nucleic Acids Research44 citations Open access
Semantic Scholar
Overexpression of MTERFD1 or MTERFD3 impairs the completion of mitochondrial DNA replication
Anne K. Hyvärinen, J. Pohjoismäki, I. Holt, H. Jacobs
2011Molecular Biology Reports44 citations
Semantic Scholar
Mitochondrial temperature homeostasis resists external metabolic stresses
M. Terzioglu, Kristo Veeroja, Toni Montonen, T. Ihalainen +6 more
2023bioRxiv41 citations Open access
Semantic Scholar
Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila.
T. Salminen, Marcos T. Oliveira, G. Cannino, Päivi Lillsunde +2 more
2017Mitochondrion (Amsterdam. Print)41 citations Open access
Semantic Scholar
A Rolling Circle Replication Mechanism Produces Multimeric Lariats of Mitochondrial DNA in Caenorhabditis elegans
S. Lewis, Priit Jõers, S. Willcox, J. Griffith +2 more
2015PLoS Genetics41 citations Open access
Semantic Scholar
Expression of the alternative oxidase mitigates beta-amyloid production and toxicity in model systems.
R. El-Khoury, Eveliina Kaulio, Katariina Lassila, D. Crowther +2 more
2016Free Radical Biology & Medicine37 citations Open access
Semantic Scholar
Phenotypic rescue of a Drosophila model of mitochondrial ANT1 disease
S. Vartiainen, Shanjun Chen, Jack George, Tea Tuomela +3 more
2014Disease Models & Mechanisms36 citations Open access
Semantic Scholar
Alternative respiratory chain enzymes: Therapeutic potential and possible pitfalls.
Sina Saari, Geovana S Garcia, K. Bremer, Marina M. Chioda +8 more
2019Biochimica et Biophysica Acta - Molecular Basis of Disease34 citations Open access
Semantic Scholar
The alternative oxidase, a tool for compensating cytochrome c oxidase deficiency in human cells.
E. Dassa, E. Dufour, Sérgio Gonçalves, H. Jacobs +1 more
2009Physiologia Plantarum : An International Journal for Plant Biology33 citations
Semantic Scholar
Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth
E. Kemppainen, Jack George, Görkem Garipler, Tea Tuomela +4 more
2016PLoS ONE32 citations Open access
Semantic Scholar
Analysis of Replication Intermediates Indicates That Drosophila melanogaster Mitochondrial DNA Replicates by a Strand-Coupled Theta Mechanism
Priit Jõers, H. Jacobs
2013PLoS ONE32 citations Open access
Semantic Scholar
A Cytoplasmic Suppressor of a Nuclear Mutation Affecting Mitochondrial Functions in Drosophila
Shanjun Chen, Marcos T. Oliveira, A. Sanz, E. Kemppainen +4 more
2012Genetics28 citations Open access
Semantic Scholar
Regulation of growth in Drosophila melanogaster: the roles of mitochondrial metabolism
H. Jacobs, Jack George, E. Kemppainen
2020Journal of Biochemistry (Tokyo)26 citations Open access
Semantic Scholar
Polyadenylation and degradation of structurally abnormal mitochondrial tRNAs in human cells
M. Toompuu, Tea Tuomela, P. Laine, L. Paulin +2 more
2018Nucleic Acids Research25 citations Open access
Semantic Scholar
dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster
Rhoda Stefanatos, A. Sriram, E. Kiviranta, Aravind K. Mohan +4 more
2012Cell Cycle25 citations Open access
Semantic Scholar
Alternative NADH dehydrogenase extends lifespan and increases resistance to xenobiotics in Drosophila
Dmytro V. Gospodaryov, O. Strilbytska, U. Semaniuk, Natalia V. Perkhulyn +6 more
2019Biogerontology (Dordrecht)24 citations Open access
Semantic Scholar
The Alternative Oxidase AOX Does Not Rescue the Phenotype of tko25t Mutant Flies
Kia Kemppainen, E. Kemppainen, H. Jacobs
2014G3: Genes, Genomes, Genetics24 citations Open access
Semantic Scholar
Effects on mitochondrial transcription of manipulating mTERF protein levels in cultured human HEK293 cells
Anne K. Hyvärinen, Mona K. Kumanto, Sanna K Marjavaara, H. Jacobs
2010BMC Molecular Biology24 citations Open access
Semantic Scholar
The Dominant Cold-Sensitive Out-Cold Mutants of Drosophila melanogaster Have Novel Missense Mutations in the Voltage-Gated Sodium Channel Gene paralytic
Helen Lindsay, R. Baines, R. ffrench-Constant, K. Lilley +2 more
2008Genetics24 citations Open access
Semantic Scholar
Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila.
Dmytro V. Gospodaryov, O. Lushchak, B. Rovenko, Natalia V. Perkhulyn +3 more
2014Biochimica et Biophysica Acta23 citations Open access
Semantic Scholar
What physiological role(s) does the alternative oxidase perform in animals?
H. Jacobs, J. Ballard
2022Biochimica et Biophysica Acta - Bioenergetics21 citations Open access
Semantic Scholar
Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia
M. Szibor, R. Schreckenberg, Z. Gizatullina, E. Dufour +16 more
2020Journal of Cellular and Molecular Medicine21 citations Open access
Semantic Scholar
Cyanide resistant respiration and the alternative oxidase pathway: A journey from plants to mammals.
R. El-Khoury, Malgorzata Rak, P. Bénit, H. Jacobs +1 more
2022Biochimica et Biophysica Acta - Bioenergetics20 citations Open access
Semantic Scholar
Repurposing mitochondria from ATP production to ROS generation drives a pro-inflammatory phenotype in macrophages that depends on succinate oxidation by complex II
E. Mills, B. Kelly, A. Logan, A. S. Costa +18 more
201820 citations
Semantic Scholar
Mitochondrial Transcription Terminator Family Members mTTF and mTerf5 Have Opposing Roles in Coordination of mtDNA Synthesis
Priit Jõers, S. Lewis, Atsushi Fukuoh, Mikael Parhiala +3 more
2013PLoS Genetics20 citations Open access
Semantic Scholar
Therapies in inborn errors of oxidative metabolism
M. Schiff, P. Bénit, H. Jacobs, J. Vockley +1 more
2012Trends in endocrinology and metabolism20 citations Open access
Semantic Scholar

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P. Rustin — researcher profile on SciRah
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E. Kemppainen — researcher profile on SciRah

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A. Sanz — researcher profile on SciRah

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Kia Kemppainen — researcher profile on SciRah

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I. Holt — researcher profile on SciRah