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N. Kobayashi · SciRah

Researcher profile · Semantic Scholar

N. Kobayashi

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N. Kobayashi — researcher profile on SciRah

h-index: 22
Works: 122
Citations: 1,677

Most-cited papers

Presence of protein-bound unconjugated bile acids in the cytoplasmic fraction of rat brain Published, JLR Papers in Press, September 2, 2003. DOI 10.1194/jlr.M300369-JLR200
N. Mano, T. Goto, M. Uchida, Koji Nishimura +3 more
2004Journal of Lipid Research117 citations Open access
Semantic Scholar
Simultaneous determination of anthraquinones in rhubarb by high-performance liquid chromatography and capillary electrophoresis.
J. Koyama, I. Morita, N. Kobayashi
2007Journal of Chromatography A87 citations
Semantic Scholar
Two-step in vitro antibody affinity maturation enables estradiol-17beta assays with more than 10-fold higher sensitivity.
N. Kobayashi, H. Oyama, Y. Kato, J. Goto +2 more
2010Analytical Chemistry54 citations
Semantic Scholar
Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds.
J. Koyama, I. Morita, N. Kobayashi, T. Osakai +2 more
2005Bioorganic & Medicinal Chemistry Letters53 citations
Semantic Scholar
Antibody engineering toward high-sensitivity high-throughput immunosensing of small molecules.
N. Kobayashi, H. Oyama
2011In Analysis50 citations
Semantic Scholar
Open-sandwich enzyme immunoassay for one-step noncompetitive detection of corticosteroid 11-deoxycortisol.
M. Ihara, Tatsuya Suzuki, N. Kobayashi, J. Goto +1 more
2009Analytical Chemistry42 citations
Semantic Scholar
Immunoenzymometric assay for a small molecule,11-deoxycortisol, with attomole-range sensitivity employing an scFv-enzyme fusion protein and anti-idiotype antibodies.
N. Kobayashi, K. Iwakami, Shuhei Kotoshiba, T. Niwa +3 more
2006Analytical Chemistry42 citations
Semantic Scholar
LC-MS/MS coupled with immunoaffinity extraction for determination of estrone, 17beta-estradiol and estrone 3-sulfate in human plasma.
Jun Hosogi, Hideyuki Tanaka, K. Fujita, T. Kuwabara +4 more
2010Journal of chromatography. B, Analytical technologies in the biomedical and life sciences40 citations
Semantic Scholar
Anti-idiotype scFv-enzyme fusion proteins: a clonable analyte-mimicking probe for standardized immunoassays targeting small biomarkers.
H. Oyama, Eri Tanaka, Tomoyo Kawanaka, I. Morita +2 more
2013Analytical Chemistry33 citations
Semantic Scholar
Anti-estradiol-17beta single-chain Fv fragments: Generation, characterization, gene randomization, and optimized phage display.
N. Kobayashi, Y. Kato, H. Oyama, Shiori Taga +4 more
2008Steroids32 citations
Semantic Scholar
Capillary electrophoresis for simultaneous determination of emodin, chrysophanol, and their 8-beta-D-glucosides.
J. Koyama, I. Morita, K. Kawanishi, K. Tagahara +1 more
2003Chemical and pharmaceutical bulletin32 citations Open access
Semantic Scholar
"Breeding" diagnostic antibodies for higher assay performance: a 250-fold affinity-matured antibody mutant targeting a small biomarker.
H. Oyama, Shuko Yamaguchi, S. Nakata, T. Niwa +1 more
2013Analytical Chemistry31 citations
Semantic Scholar
Gaussia Luciferase as a Genetic Fusion Partner with Antibody Fragments for Sensitive Immunoassay Monitoring of Clinical Biomarkers.
H. Oyama, I. Morita, Y. Kiguchi, Sayaka Miyake +4 more
2015Analytical Chemistry29 citations Open access
Semantic Scholar
Antiallergic activity of aqueous extracts and constituents of Taxus yunnanensis.
J. Koyama, I. Morita, N. Kobayashi, K. Hirai +3 more
2006Biological and Pharmaceutical Bulletin26 citations Open access
Semantic Scholar
Cellular Interaction and Cytotoxicity of the Iowa Mutation of Apolipoprotein A-I (ApoA-IIowa) Amyloid Mediated by Sulfate Moieties of Heparan Sulfate*
Kaori Kuwabara, Kazuchika Nishitsuji, Kenji Uchimura, Shang-Cheng Hung +6 more
2015Journal of Biological Chemistry25 citations Open access
Semantic Scholar
NanoLuc luciferase as a suitable fusion partner of recombinant antibody fragments for developing sensitive luminescent immunoassays.
H. Oyama, Y. Kiguchi, I. Morita, Takayuki Miyashita +8 more
2021Analytica Chimica Acta24 citations
Semantic Scholar
Generation of a Novel Monoclonal Antibody against Cortisol-[C-4]-Bovine Serum Albumin Conjugate: Application to Enzyme-Linked Immunosorbent Assay for Urinary and Serum Cortisol
N. Kobayashi, Pi Sun, Y. Fujimaki, T. Niwa +3 more
2002Analytical Sciences24 citations Open access
Semantic Scholar
Correlation of redox potentials and inhibitory effects on Epstein-Barr virus activation of naphthoquinones.
J. Koyama, I. Morita, N. Kobayashi, T. Osakai +4 more
2003Cancer Letters23 citations
Semantic Scholar
PM Q-probe: A fluorescent binding protein that converts many antibodies to a fluorescent biosensor.
Jin-Hua Dong, C. Miyake, Takanobu Yasuda, H. Oyama +7 more
2020Biosensors & bioelectronics22 citations Open access
Semantic Scholar
Toward in vivo imaging of heart disease using a radiolabeled single-chain Fv fragment targeting tenascin-C.
N. Kobayashi, K. Odaka, Tomoya Uehara, K. Imanaka-Yoshida +11 more
2011Analytical Chemistry22 citations Open access
Semantic Scholar
Enzyme-linked immunosorbent assay for monitoring toxic dioxin congeners in milk based on a newly generated monoclonal anti-dioxin antibody.
M. Okuyama, N. Kobayashi, Wakako Takeda, T. Anjo +4 more
2004Analytical Chemistry22 citations
Semantic Scholar
Single-chain Fv fragments derived from an anti-11-deoxycortisol antibody. Affinity, specificity, and idiotype analysis.
N. Kobayashi, Kana Shibahara, Kayo Ikegashira, K. Shibusawa +1 more
2002Steroids22 citations
Semantic Scholar
One-Shot In Vitro Evolution Generated an Antibody Fragment for Testing Urinary Cotinine with More Than 40-Fold Enhanced Affinity.
H. Oyama, I. Morita, Y. Kiguchi, Erika Banzono +7 more
2017Analytical Chemistry21 citations Open access
Semantic Scholar
An enzyme-linked immunometric assay for cortisol based on idiotype-anti-idiotype reactions.
T. Niwa, Takayuki Kobayashi, Pi Sun, J. Goto +2 more
2009Analytica Chimica Acta21 citations
Semantic Scholar
Simultaneous determination of anthraquinones, their 8-beta-D-glucosides, and sennosides of Rhei Rhizoma by capillary electrophoresis.
J. Koyama, I. Morita, H. Fujiyoshi, N. Kobayashi
2005Chemical and pharmaceutical bulletin21 citations Open access
Semantic Scholar
Antibody Fragments for On-Site Testing of Cannabinoids Generated via in Vitro Affinity Maturation.
I. Morita, H. Oyama, Mayumi Yasuo, Kazuhisa Matsuda +6 more
2017Biological and Pharmaceutical Bulletin19 citations Open access
Semantic Scholar
Iowa Mutant Apolipoprotein A-I (ApoA-IIowa) Fibrils Target Lysosomes
Hirokazu Kameyama, Hiroyuki Nakajima, Kazuchika Nishitsuji, Shiho Mikawa +5 more
2016Scientific Reports19 citations Open access
Semantic Scholar
Monoclonal anti-idiotype antibodies recognizing the variable region of a high-affinity antibody against 11-deoxycortisol. Production, characterization and application to a sensitive noncompetitive immunoassay.
N. Kobayashi, K. Shibusawa, K. Kubota, N. Hasegawa +3 more
2003JIM - Journal of Immunological Methods19 citations
Semantic Scholar
A monoclonal antibody-based enzyme-linked immunosorbent assay of glycolithocholic acid sulfate in human urine for liver function test.
N. Kobayashi, H. Katsumata, Yoshiaki Uto, J. Goto +3 more
2002Steroids19 citations
Semantic Scholar
Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein
Takashi Ohgita, Hiroki Kono, I. Morita, H. Oyama +3 more
2023Scientific Reports18 citations Open access
Semantic Scholar
Two chalcones, 4-hydroxyderricin and xanthoangelol, stimulate GLUT4-dependent glucose uptake through the LKB1/AMP-activated protein kinase signaling pathway in 3T3-L1 adipocytes.
M. Ohta, A. Fujinami, N. Kobayashi, Akiko Amano +11 more
2015Nutrition Research18 citations
Semantic Scholar
"Cleavable" hapten-biotin conjugates: preparation and use for the generation of anti-steroid single-domain antibody fragments.
N. Kobayashi, H. Oyama, Masanori Nakano, T. Kanda +5 more
2009Analytical Biochemistry18 citations
Semantic Scholar
Correlation between reduction potentials and inhibitions of Epstein-Barr virus activation by anthraquinone derivatives.
J. Koyama, Yutaka Nisino, I. Morita, N. Kobayashi +2 more
2008Bioorganic & Medicinal Chemistry Letters17 citations
Semantic Scholar
Generation of a single-chain Fv fragment for the monitoring of deoxycholic acid residues anchored on endogenous proteins.
N. Kobayashi, Mamoru Ohtoyo, Eriko Wada, Y. Kato +2 more
2005Steroids17 citations
Semantic Scholar
Dissociation-independent selection of high-affinity anti-hapten phage antibodies using cleavable biotin-conjugated haptens.
N. Kobayashi, Tsuyoshi Karibe, J. Goto
2005Analytical Biochemistry17 citations
Semantic Scholar
Clonal array profiling of scFv-displaying phages for high-throughput discovery of affinity-matured antibody mutants
Y. Kiguchi, H. Oyama, I. Morita, Mai Morikawa +10 more
2020Scientific Reports16 citations Open access
Semantic Scholar
A monoclonal antibody-based enzyme-linked immunosorbent assay for human urinary cotinine to monitor tobacco smoke exposure
N. Kobayashi, Erika Banzono, Y. Shimoda, H. Oyama +3 more
201116 citations
Semantic Scholar
A Nonenzymatic Modification of the Amino-terminal Domain of Histone H3 by Bile Acid Acyl Adenylate*
N. Mano, K. Kasuga, N. Kobayashi, J. Goto
2004Journal of Biological Chemistry16 citations Open access
Semantic Scholar
Production and characterization of group-specific monoclonal antibodies recognizing nonamidated, glycine- and taurine-amidated ursodeoxycholic acid 7-N-acetylglucosaminides.
N. Kobayashi, Hiroyuki Oiwa, J. Goto
1998Journal of Steroid Biochemistry and Molecular Biology16 citations
Semantic Scholar
Immunochemical monitoring of psilocybin and psilocin to identify hallucinogenic mushrooms.
I. Morita, H. Oyama, Y. Kiguchi, Akari Oguri +6 more
2020Journal of Pharmaceutical and Biomedical Analysis15 citations
Semantic Scholar
Correlation between oxidation potentials and inhibitory effects on Epstein-Barr virus activation of flavonoids.
J. Koyama, I. Morita, N. Kobayashi, T. Konoshima +3 more
2008Cancer Letters15 citations
Semantic Scholar
Ashitaba (Angelica Keiskei) Exudate Prevents Increases in Plasminogen Activator Inhibitor-1 Induced by Obesity in Tsumura Suzuki Obese Diabetic Mice
M. Ohta, A. Fujinami, K. Oishi, N. Kobayashi +2 more
2019Journal of Dietary Supplements14 citations
Semantic Scholar
Idiotype-anti-idiotype-based noncompetitive enzyme-linked immunosorbent assay of ursodeoxycholic acid 7-N-acetylglucosaminides in human urine with subfemtomole range sensitivity.
N. Kobayashi, K. Kubota, Hiroyuki Oiwa, J. Goto +2 more
2003JIM - Journal of Immunological Methods14 citations
Semantic Scholar
Seeking high-priority mutations enabling successful antibody-breeding: systematic analysis of a mutant that gained over 100-fold enhanced affinity
H. Oyama, Y. Kiguchi, I. Morita, Chika Yamamoto +8 more
2020Scientific Reports13 citations Open access
Semantic Scholar
Characterization of emodin metabolites in Raji cells by LC-APCI-MS/MS.
J. Koyama, A. Takeuchi, I. Morita, Y. Nishino +3 more
2009Bioorganic & Medicinal Chemistry13 citations
Semantic Scholar
A Selective Immunoaffinity Chromatography for Determination of Plasma 1α,25-Dihydroxyvitamin D3: Application of Specific Antibodies Raised against a 1α,25-Dihydroxyvitamin D3–Bovine Serum Albumin Conjugate Linked through the 11α-Position
N. Kobayashi, T. Imazu, J. Kitahori, H. Mano +1 more
199713 citations
Semantic Scholar
The VH framework region 1 as a target of efficient mutagenesis for generating a variety of affinity-matured scFv mutants
Y. Kiguchi, H. Oyama, I. Morita, Y. Nagata +2 more
2021Scientific Reports12 citations Open access
Semantic Scholar
Antibodies and Engineered Antibody Fragments against M13 Filamentous Phage to Facilitate Phage-Display-Based Molecular Breeding.
Y. Kiguchi, H. Oyama, I. Morita, Emiko Katayama +4 more
2018Biological and Pharmaceutical Bulletin12 citations Open access
Semantic Scholar
Correlation between reduction potentials and inhibitory effects on Epstein-Barr virus activation by emodin derivatives.
J. Koyama, M. Inoue, I. Morita, N. Kobayashi +3 more
2006Cancer Letters12 citations
Semantic Scholar
Correlation between reduction potentials and inhibitory effects on Epstein-Barr virus activation of poly-substituted anthraquinones.
J. Koyama, I. Morita, N. Kobayashi, T. Osakai +2 more
2005Cancer Letters12 citations
Semantic Scholar

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