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S. Krahenbuhl · SciRah

Researcher profile · Semantic Scholar

S. Krahenbuhl

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S. Krahenbuhl — researcher profile on SciRah

h-index: 71
Works: 412
Citations: 16K

Most-cited papers

Mechanisms of statin-associated skeletal muscle-associated symptoms.
J. Bouitbir, Gerda M. Sanvee, M. Panajatovic, F. Singh +1 more
2020Pharmacological Research139 citations
Semantic Scholar
Pharmacological profile of mephedrone analogs and related new psychoactive substances.
Dino Luethi, K. E. Kolaczynska, Luca Docci, S. Krahenbuhl +2 more
2017Neuropharmacology97 citations Open access
Semantic Scholar
Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis
F. Paech, J. Bouitbir, S. Krahenbuhl
2017Frontiers in Pharmacology90 citations Open access
Semantic Scholar
Unmet Needs in LDL-C Lowering: When Statins Won’t Do!
S. Krahenbuhl, Ivana Pavik-Mezzour, A. von Eckardstein
2016Drugs90 citations Open access
Semantic Scholar
Comparison of Liver Cell Models Using the Basel Phenotyping Cocktail
B. Berger, M. Donzelli, Swarna Maseneni, F. Boess +3 more
2016Frontiers in Pharmacology84 citations Open access
Semantic Scholar
Hepatocellular Toxicity of Imidazole and Triazole Antimycotic Agents
Patrizia Haegler, L. Joerin, S. Krahenbuhl, J. Bouitbir
2017Toxicological Sciences76 citations
Semantic Scholar
Key Learning Outcomes for Clinical Pharmacology and Therapeutics Education in Europe: A Modified Delphi Study
D. Brinkman, J. Tichelaar, L. Mokkink, T. Christiaens +125 more
2018Clinical pharmacology and therapy72 citations Open access
Semantic Scholar
Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells.
F. Paech, Cécile Mingard, David Grünig, V. Abegg +2 more
2018Toxicology70 citations Open access
Semantic Scholar
Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug
B. Berger, F. Bachmann, U. Duthaler, S. Krahenbuhl +1 more
2018Frontiers in Pharmacology65 citations Open access
Semantic Scholar
Mitochondrial oxidative stress plays a critical role in the cardiotoxicity of sunitinib: Running title: Sunitinib and oxidative stress in hearts.
J. Bouitbir, A. Alshaikhali, M. Panajatovic, V. Abegg +2 more
2019Toxicology64 citations
Semantic Scholar
Predictive impact of antibiotics in patients with advanced non small-cell lung cancer receiving immune checkpoint inhibitors
A. Schett, S. Rothschild, A. Curioni-Fontecedro, S. Krahenbuhl +4 more
2019Cancer Chemotherapy and Pharmacology62 citations
Semantic Scholar
Pharmacological profile of methylphenidate-based designer drugs.
Dino Luethi, P. Kaeser, Simon D. Brandt, S. Krahenbuhl +2 more
2017Neuropharmacology60 citations Open access
Semantic Scholar
Mechanisms of hepatocellular toxicity associated with new psychoactive synthetic cathinones.
Dino Luethi, M. Liechti, S. Krahenbuhl
2017Toxicology53 citations Open access
Semantic Scholar
Exploration and application of a liver-on-a-chip device in combination with modelling and simulation for quantitative drug metabolism studies.
Luca Docci, Nicoló Milani, T. Ramp, Andrea A. Romeo +7 more
2022Lab on a Chip46 citations Open access
Semantic Scholar
Imatinib and Dasatinib Provoke Mitochondrial Dysfunction Leading to Oxidative Stress in C2C12 Myotubes and Human RD Cells
J. Bouitbir, M. Panajatovic, T. Fréchard, Noëmi Johanna Roos +1 more
2020Frontiers in Pharmacology44 citations Open access
Semantic Scholar
Effect of l-carnitine supplementation on the body carnitine pool, skeletal muscle energy metabolism and physical performance in male vegetarians
K. Nováková, O. Kummer, J. Bouitbir, Sonja D. Stoffel +6 more
2016European Journal of Nutrition42 citations
Semantic Scholar
Population pharmacokinetics of oral ivermectin in venous plasma and dried blood spots in healthy volunteers
U. Duthaler, C. Suenderhauf, M. Karlsson, Janine Hussner +3 more
2019British Journal of Clinical Pharmacology41 citations Open access
Semantic Scholar
Cytochrome P450 enzymes contribute to the metabolism of LSD to nor-LSD and 2-oxo-3-hydroxy-LSD: Implications for clinical LSD use.
Dino Luethi, M. Hoener, S. Krahenbuhl, M. Liechti +1 more
2019Biochemical Pharmacology39 citations
Semantic Scholar
The catechol-O-methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory chain in HepaRG cells.
David Grünig, Andrea Felser, J. Bouitbir, S. Krahenbuhl
2017Toxicology in Vitro38 citations Open access
Semantic Scholar
Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently
U. Duthaler, F. Bachmann, C. Suenderhauf, Tanja Grandinetti +5 more
2022Clinical Pharmacokinetics37 citations Open access
Semantic Scholar
Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072
F. Paech, S. Messner, J. Spickermann, Mathias Wind +8 more
2017Archives of Toxicology37 citations
Semantic Scholar
Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2
F. Bachmann, U. Duthaler, Henriette E. Meyer zu Schwabedissen, M. Puchkov +3 more
2020Clinical pharmacology and therapy34 citations Open access
Semantic Scholar
Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells
David Grünig, U. Duthaler, S. Krahenbuhl
2018Frontiers in Pharmacology34 citations Open access
Semantic Scholar
The Risk of Muscular Events Among New Users of Hydrophilic and Lipophilic Statins: an Observational Cohort Study
A. M. Mueller, E. Liakoni, C. Schneider, T. Burkard +4 more
2021Journal of general internal medicine31 citations Open access
Semantic Scholar
Para-Halogenation Affects Monoamine Transporter Inhibition Properties and Hepatocellular Toxicity of Amphetamines and Methcathinones
Dino Luethi, M. Walter, Xun Zhou, Deborah Rudin +2 more
2019Frontiers in Pharmacology31 citations Open access
Semantic Scholar
No Clinically Relevant Interactions of St. John's Wort Extract Ze 117 Low in Hyperforin With Cytochrome P450 Enzymes and P‐glycoprotein
C. Zahner, E. Kruttschnitt, J. Uricher, Michael Lissy +4 more
2019Planta Medica30 citations Open access
Semantic Scholar
IGF-1 prevents simvastatin-induced myotoxicity in C2C12 myotubes
A. Bonifacio, Gerda M. Sanvee, K. Brecht, D. Kratschmar +3 more
2017Archives of Toxicology30 citations
Semantic Scholar
The uricosuric benzbromarone disturbs the mitochondrial redox homeostasis and activates the NRF2 signaling pathway in HepG2 cells.
Noëmi Johanna Roos, U. Duthaler, J. Bouitbir, S. Krahenbuhl
2020Free Radical Biology & Medicine29 citations
Semantic Scholar
Prognostic impact of polypharmacy and drug interactions in patients with advanced cancer
A. Hoemme, H. Barth, M. Haschke, S. Krahenbuhl +8 more
2019Cancer Chemotherapy and Pharmacology28 citations Open access
Semantic Scholar
In Vitro to In Vivo Extrapolation of Metabolic Clearance for UGT Substrates Using Short-Term Suspension and Long-Term Co-cultured Human Hepatocytes
Luca Docci, Florian Klammers, Aynur Ekiciler, Birgit Molitor +5 more
2020AAPS Journal27 citations
Semantic Scholar
Molecular Toxicological Mechanisms of Synthetic Cathinones on C2C12 Myoblasts
Xun Zhou, Dino Luethi, Gerda M. Sanvee, J. Bouitbir +2 more
2019International Journal of Molecular Sciences27 citations Open access
Semantic Scholar
Recreational use of carfentanil – a case report with laboratory confirmation
Sabine Müller, S. Nussbaumer, G. Plitzko, R. Ludwig +3 more
2018Clinical toxicology27 citations
Semantic Scholar
Development and validation of an LC-MS/MS method for the analysis of ivermectin in plasma, whole blood, and dried blood spots using a fully automatic extraction system.
Urs Duthaler, C. Suenderhauf, S. Gaugler, Beatrice Vetter +2 more
2019Journal of Pharmaceutical and Biomedical Analysis25 citations
Semantic Scholar
Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS).
Y. Yilmaz, G. Williams, M. Walles, Nenad Manevski +2 more
2019Drug Metabolism Letters24 citations Open access
Semantic Scholar
PGC-1β modulates statin-associated myotoxicity in mice
F. Singh, J. Zoll, U. Duthaler, A. Charles +7 more
2018Archives of Toxicology23 citations Open access
Semantic Scholar
Leucopenia associated with metamizole: a case-control study.
L. Blaser, Hala Hassna, S. Hofmann, A. Holbro +5 more
2017Swiss medical weekly23 citations Open access
Semantic Scholar
Effects of Hypericum perforatum (St John's wort) on the pharmacokinetics and pharmacodynamics of rivaroxaban in humans
Irene Scholz, E. Liakoni, F. Hammann, K. E. Grafinger +4 more
2020British Journal of Clinical Pharmacology22 citations
Semantic Scholar
Application of New Cellular and Microphysiological Systems to Drug Metabolism Optimization and Their Positioning Respective to In Silico Tools
Luca Docci, N. Parrott, S. Krahenbuhl, S. Fowler
2019SLAS discovery : advancing life sciences R & D21 citations Open access
Semantic Scholar
Sex differences in the pharmacology of itch therapies-a narrative review.
Yasmin Schmid, A. Navarini, Zita-Rose Manjaly Thomas, B. Pfleiderer +2 more
2019Current opinion in pharmacology (Print)20 citations
Semantic Scholar
Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin.
K. Brecht, Virginie Riebel, P. Couttet, F. Paech +5 more
2017Toxicology in Vitro20 citations
Semantic Scholar
Pharmacokinetics and phenotyping properties of the Basel phenotyping cocktail combination capsule in healthy male adults
C. Suenderhauf, B. Berger, M. Puchkov, Yasmin Schmid +5 more
2019British Journal of Clinical Pharmacology19 citations Open access
Semantic Scholar
Construction and Verification of Physiologically Based Pharmacokinetic Models for Four Drugs Majorly Cleared by Glucuronidation: Lorazepam, Oxazepam, Naloxone, and Zidovudine
Luca Docci, Kenichi Umehara, S. Krahenbuhl, S. Fowler +1 more
2020AAPS Journal18 citations
Semantic Scholar
PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in mice
M. Panajatovic, F. Singh, Noëmi Johanna Roos, U. Duthaler +3 more
2019Acta Physiologica17 citations Open access
Semantic Scholar
Role of Cytochrome P450 3A4 and 1A2 Phenotyping in Patients with Advanced Non‐small‐Cell Lung Cancer Receiving Erlotinib Treatment
Z. Parra-Guillén, Peter B. Berger, M. Haschke, M. Donzelli +7 more
2017Basic & Clinical Pharmacology & Toxicology17 citations
Semantic Scholar
Pharmacokinetics of Transdermal Etofenamate and Diclofenac in Healthy Volunteers
S. Drago, R. Imboden, P. Schlatter, Mirabel Buylaert +2 more
2017Basic & Clinical Pharmacology & Toxicology17 citations Open access
Semantic Scholar
Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells
Noëmi Johanna Roos, Diell Aliu, J. Bouitbir, S. Krahenbuhl
2020Frontiers in Pharmacology16 citations Open access
Semantic Scholar
Metabolism of the Dual Orexin Receptor Antagonist ACT-541468, Based on Microtracer/ Accelerator Mass Spectrometry.
C. Muehlan, H. Fischer, D. Zimmer, Hamed Aissaoui +6 more
2019Current drug metabolism16 citations
Semantic Scholar
Metamizole-associated neutropenia: Comparison of patients with neutropenia and metamizole-tolerant patients.
Deborah Rudin, J. Spoendlin, A. L. Cismaru, E. Liakoni +5 more
2019European journal of internal medicine16 citations
Semantic Scholar
Using dried blood spots to facilitate therapeutic drug monitoring of antiretroviral drugs in resource-poor regions
U. Duthaler, B. Berger, S. Erb, M. Battegay +7 more
2018Journal of Antimicrobial Chemotherapy16 citations
Semantic Scholar
The hepatotoxic potential of protein kinase inhibitors predicted with Random Forest and Artificial Neural Networks.
Verena Schöning, S. Krahenbuhl, J. Drewe
2018Toxicology Letters16 citations
Semantic Scholar

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J. Bouitbir — researcher profile on SciRah
M. Haschke×11
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U. Duthaler×11
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Dino Luethi×6
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M. Panajatovic×5

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Luca Docci — researcher profile on SciRah

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F. Paech — researcher profile on SciRah

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N. Parrott — researcher profile on SciRah

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Noëmi Johanna Roos — researcher profile on SciRah