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Li Xie · SciRah

Researcher profile · Semantic Scholar

Li Xie

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Li Xie — researcher profile on SciRah

h-index: 13
Works: 45
Citations: 1,505

Most-cited papers

Drug Discovery Using Chemical Systems Biology: Identification of the Protein-Ligand Binding Network To Explain the Side Effects of CETP Inhibitors
Li Xie, Jerry Li, Lei Xie, P. Bourne
2009PLoS Comput. Biol.254 citations Open access
Semantic Scholar
Novel computational approaches to polypharmacology as a means to define responses to individual drugs.
Lei Xie, Li Xie, Sarah L. Kinnings, P. Bourne
2012Annual Review of Pharmacology and Toxicology208 citations
Semantic Scholar
Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model
Roger L. Chang, Li Xie, Lei Xie, P. Bourne +1 more
2010PLoS Comput. Biol.203 citations Open access
Semantic Scholar
Drug Discovery Using Chemical Systems Biology: Weak Inhibition of Multiple Kinases May Contribute to the Anti-Cancer Effect of Nelfinavir
Li Xie, T. Evangelidis, Lei Xie, P. Bourne
2011PLoS Comput. Biol.171 citations Open access
Semantic Scholar
Structure-based Systems Biology for Analyzing Off-target Binding
Lei Xie, Li Xie, P. Bourne
2011Current Opinion in Structural Biology153 citations Open access
Semantic Scholar
Quantifying Reproducibility in Computational Biology: The Case of the Tuberculosis Drugome
D. Garijo, Sarah L. Kinnings, Li Xie, Linfu Xie +3 more
2013PLoS ONE118 citations Open access
Semantic Scholar
The Mycobacterium tuberculosis Drugome and Its Polypharmacological Implications
Sarah L. Kinnings, Li Xie, K. H. Fung, R. Jackson +2 more
2010PLoS Comput. Biol.107 citations Open access
Semantic Scholar
A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discovery
Linfu Xie, Li Xie, P. Bourne
2009Bioinform.100 citations Open access
Semantic Scholar
Towards Structural Systems Pharmacology to Study Complex Diseases and Personalized Medicine
Linfu Xie, Xiaoxia Ge, Hepan Tan, Li Xie +4 more
2014PLoS Comput. Biol.69 citations Open access
Semantic Scholar
Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62*
L. Tsai, Lei Xie, Kim Dore, Li Xie +7 more
2015Journal of Biological Chemistry31 citations Open access
Semantic Scholar
Elucidation of genome-wide understudied proteins targeted by PROTAC-induced degradation using interpretable machine learning
Li Xie, Linfu Xie
2023bioRxiv25 citations Open access
Semantic Scholar
Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia
Li Xie, Clara Ng, Thahmina Ali, Raoul Valencia +7 more
2013BMC Genomics25 citations Open access
Semantic Scholar
End-to-end sequence-structure-function meta-learning predicts genome-wide chemical-protein interactions for dark proteins
Tian Cai, Li Xie, Shuo Zhang, Muge Chen +9 more
2023PLoS Comput. Biol.22 citations Open access
Semantic Scholar
Pathway-Centric Structure-Based Multi-Target Compound Screening for Anti-Virulence Drug Repurposing
Li Xie, Lei Xie
2019International Journal of Molecular Sciences10 citations Open access
Semantic Scholar
The Plasmodium falciparum Drugome And Its Polypharmacological Implications
Yinliang Zhang, Li Xie, Linfu Xie, P. Bourne
2016bioRxiv5 citations Open access
Semantic Scholar
eMOSAIC: Multi-modal Out-of-distribution Uncertainty Quantification Streamlines Large-scale Polypharmacology
Amitesh Badkul, Li Xie, Shuo Zhang, Lei Xie
2024bioRxiv4 citations Open access
Semantic Scholar
Sequence-based drug-target binding site pre-training enables cryptic pocket detection and improves binding affinity and kinetics prediction
Shuo Zhang, Li Xie, Daniel Tiourine, Lei Xie
2026bioRxiv1 citations Open access
Semantic Scholar
Learning Universal and Robust 3D Molecular Representations with Graph Convolutional Networks
Shuo Zhang, Yang Liu, Li Xie, Lei Xie
2023arXiv.org0 citations Open access
Semantic Scholar
Binding Site-enhanced Sequence Pretraining and Out-of-cluster Meta-learning Predict Genome-Wide Chemical-Protein Interactions for Dark Proteins
Tian Cai, Li Xie, Shuo Zhang, Muge Chen +9 more
2022bioRxiv0 citations Open access
Semantic Scholar
Exploration of Dark Chemical Genomics Space via Portal Learning: Applied to Targeting the Undruggable Genome and COVID-19 Anti-infectious Polypharmacology
Tian Cai, Li Xie, Muge Chen, Yang Liu +6 more
20210 citations
Semantic Scholar
TB-Drugome - Run 126
Mjn Jones, Li Xie, K. H. Fung, Richard Jackson +2 more
20160 citations
Semantic Scholar
Combating Chagas Disease Through Inhibition of Tiam1, a Rho GTPase Guanine Nucleotide Exchange Factor
C. Krishna, Li Xie, Celine DerMarderossian, P. Bourne
2016bioRxiv0 citations Open access
Semantic Scholar
p 62 is a molecular target for ZIP 1 Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p 62
L. Tsai, Lei Xie, Kim Dore, Li Xie +8 more
20150 citations
Semantic Scholar
成人移动学习的微课设计与制作——以“Word2010邮件合并的应用”微课为例
Li Xie, Linfu Xie, Xiao-Hua Deng
20150 citations
Semantic Scholar
Scaffolding of atypical protein kinase C to p62 is disrupted by the pseudosubstrate peptide ZIP (802.4)
L. Tsai, Linfu Xie, Li Xie, P. Bourne +1 more
20140 citations
Semantic Scholar
structural pharmacology to study complex diseases and personalized medicine.
Lei Xie, Xiaoxiao Ge, Hepan Tan, Li Xie +4 more
20140 citations
Semantic Scholar
TB-Drugome Workflow Input Files
G. Daniel, Sarah L. Kinnings, P. Bourne, Lei Xie +2 more
20130 citations
Semantic Scholar
SMAP configuration file
G. Daniel, Sarah L. Kinnings, P. Bourne, Xie Lei +3 more
20130 citations
Semantic Scholar
Solved structures list
G. Daniel, P. Bourne, Xie Lei, Yin-Liang Zhang +3 more
20130 citations
Semantic Scholar
Homology Model list
G. Daniel, Sarah L. Kinnings, P. Bourne, Xie Lei +3 more
20130 citations
Semantic Scholar
Drug key file
G. Daniel, Yin-Liang Zhang, G. Yolanda, Li Xie +3 more
20130 citations
Semantic Scholar
Solved structures file
G. Daniel, Yin-Liang Zhang, G. Yolanda, Li Xie +3 more
20130 citations
Semantic Scholar
Visualization of highly connected drugs
G. Daniel, Yin-Liang Zhang, G. Yolanda, Li Xie +4 more
20130 citations
Semantic Scholar
Drug Binding site file
G. Daniel, B. Phil, Yin-Liang Zhang, G. Yolanda +3 more
20130 citations
Semantic Scholar
TB-Drugome Workflow outputs
G. Daniel, K. Sarah, Li Xie, Xie Lei +3 more
20130 citations
Semantic Scholar
Template PDB file
G. Daniel, G. Yolanda, Yin-Liang Zhang, Lei Xie +3 more
20130 citations
Semantic Scholar
民国时期和田河流域洛浦垦区垦荒、撂荒地的空间分布格局——基于历史资料的信息可视化重建
Li Xie, Li Xie
20130 citations
Semantic Scholar
Homology model file
G. Daniel, Sarah L. Kinnings, P. Bourne, Xie Lei +3 more
20130 citations
Semantic Scholar
Non relevant results
G. Daniel, Yin-Liang Zhang, G. Yolanda, Li Xie +3 more
20130 citations
Semantic Scholar
Highly connected drug file
G. Daniel, Lei Xie, Yin-Liang Zhang, G. Yolanda +3 more
20130 citations
Semantic Scholar
TB Protein information file
G. Daniel, Lei Xie, Yin-Liang Zhang, G. Yolanda +3 more
20130 citations
Semantic Scholar
An integrated workflow for proteome-wide off-target identification and polypharmacology drug design
T. Evangelidis, Li Xie, Philip E. Bourne
20122012 IEEE International Conference on Bioinformatics and Biomedicine Workshops0 citations
Semantic Scholar
Discrepancies in purified and cellular PKMζ inhibition profiles invalidate its proposed role as a mediator of memory
Cicely L. Schramm, A. Wu-Zhang, Sadegh Nabavi, Linfu Xie +4 more
20120 citations
Semantic Scholar
A Systematic Approach to Identifying Protein-Ligand Binding Profiles on a Proteome Scale
Li Xie, N. Buchmeier, Linfu Xie, P. Bourne
20080 citations Open access
Semantic Scholar

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