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C. Holmes · SciRah

Researcher profile · Semantic Scholar

C. Holmes

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C. Holmes — researcher profile on SciRah

h-index: 71
Works: 215
Citations: 45K

Most-cited papers

Neuroinflammation in Alzheimer's Disease
M. Heneka, M. Carson, J. E. El Khoury, G. Landreth +33 more
2015Lancet Neurology5,481 citations Open access
Semantic Scholar
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease
J. Lambert, C. Ibrahim-Verbaas, D. Harold, A. Naj +178 more
2013Nature Genetics4,314 citations Open access
Semantic Scholar
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Brian W. Kunkle, B. Grenier-Boley, R. Sims, J. Bis +464 more
2019Nature Genetics2,490 citations Open access
Semantic Scholar
New insights into the genetic etiology of Alzheimer’s disease and related dementias
C. Bellenguez, F. Küçükali, I. Jansen, L. Kleineidam +496 more
2022Nature Genetics1,984 citations Open access
Semantic Scholar
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
D. Harold, R. Abraham, P. Hollingworth, R. Sims +83 more
2013Nature Genetics1,354 citations Open access
Semantic Scholar
Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
V. Escott-Price, C. Bellenguez, Li-San Wang, S. Choi +184 more
2014PLoS ONE1,240 citations Open access
Semantic Scholar
Microglial priming in neurodegenerative disease
V. H. Perry, C. Holmes
2014Nature Reviews Neurology1,090 citations
Semantic Scholar
Rare coding variants in PLCG2, ABI3 and TREM2 implicate microglial-mediated innate immunity in Alzheimer’s disease
R. Sims, S. J. van der Lee, A. Naj, C. Bellenguez +236 more
2017Nature Genetics944 citations Open access
Semantic Scholar
Common polygenic variation enhances risk prediction for Alzheimer's disease.
V. Escott-Price, R. Sims, C. Bannister, D. Harold +23 more
2015Brain : a journal of neurology428 citations Open access
Semantic Scholar
Periodontitis and Cognitive Decline in Alzheimer’s Disease
M. Ide, Marina Harris, Annette Stevens, R. Sussams +10 more
2016PLoS ONE416 citations Open access
Semantic Scholar
Review: Systemic inflammation and Alzheimer's disease
C. Holmes
2013Neuropathology and Applied Neurobiology335 citations
Semantic Scholar
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
I. de Rojas, S. Moreno-Grau, N. Tesi, B. Grenier-Boley +496 more
2021Nature Communications295 citations Open access
Semantic Scholar
Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunization.
E. Zotova, V. Bharambe, Matthew Cheaveau, W. Morgan +6 more
2013Brain : a journal of neurology260 citations
Semantic Scholar
Convergent genetic and expression data implicate immunity in Alzheimer's disease
L. Jones, J. Lambert, Li-San Wang, S. Choi +182 more
2014Alzheimer's & Dementia199 citations Open access
Semantic Scholar
Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer’s disease: study protocol for a randomised controlled trial (ELAD study)
G. Femminella, E. Frangou, S. Love, Gail Busza +30 more
2019Trials195 citations Open access
Semantic Scholar
Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease
H. Holstege, M. Hulsman, C. Charbonnier, B. Grenier-Boley +103 more
2022Nature Genetics181 citations Open access
Semantic Scholar
Peripheral inflammatory cytokines and immune balance in Generalised Anxiety Disorder: case-controlled study
R. Hou, M. Garner, C. Holmes, C. Osmond +3 more
2017Brain, behavior, and immunity177 citations Open access
Semantic Scholar
Persistent neuropathological effects 14 years following amyloid-β immunization in Alzheimer’s disease
J. Nicoll, G. R. Buckland, C. Harrison, Anton M. Page +5 more
2019Brain : a journal of neurology165 citations Open access
Semantic Scholar
Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO-AD) trial: secondary and post-hoc analyses.
R. Howard, R. McShane, J. Lindesay, C. Ritchie +23 more
2015Lancet Neurology147 citations Open access
Semantic Scholar
Etanercept in Alzheimer disease
J. Butchart, L. Brook, Vivienne Hopkins, J. Teeling +10 more
2015Neurology133 citations Open access
Semantic Scholar
Core outcome measures for interventions to prevent or slow the progress of dementia for people living with mild to moderate dementia: Systematic review and consensus recommendations
Lucy A. Webster, D. Groskreutz, Anna Grinbergs-Saull, Rob Howard +33 more
2017PLoS ONE132 citations Open access
Semantic Scholar
Targeting innate immunity for neurodegenerative disorders of the central nervous system
K. Andreasson, A. Bachstetter, M. Colonna, F. Ginhoux +17 more
2016Journal of Neurochemistry127 citations Open access
Semantic Scholar
The Locus Coeruleus in Aging and Alzheimer’s Disease: A Postmortem and Brain Imaging Review
Rebecca C. Beardmore, R. Hou, A. Darekar, C. Holmes +1 more
2021Journal of Alzheimer's Disease105 citations Open access
Semantic Scholar
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Brian W. Kunkle, B. Grenier-Boley, R. Sims, J. Bis +464 more
2019Nature Genetics85 citations Open access
Semantic Scholar
Alzheimer’s disease polygenic risk score as a predictor of conversion from mild-cognitive impairment
S. Chaudhury, K. Brookes, T. Patel, Abigail Fallows +10 more
2019Translational Psychiatry82 citations Open access
Semantic Scholar
Vagus Nerve Stimulation as a Potential Therapy in Early Alzheimer’s Disease: A Review
M. Vargas-Caballero, Hannah Warming, R. Walker, C. Holmes +2 more
2022Frontiers in Human Neuroscience79 citations Open access
Semantic Scholar
Development of a core outcome set for disease modification trials in mild to moderate dementia: a systematic review, patient and public consultation and consensus recommendations.
Lucy A. Webster, D. Groskreutz, Anna Grinbergs-Saull, Rob Howard +35 more
2017Health Technology Assessment71 citations Open access
Semantic Scholar
Systemic infection modifies the neuroinflammatory response in late stage Alzheimer’s disease
S. Rakić, Yat M. A. Hung, Matthew Smith, D. So +9 more
2018Acta Neuropathologica Communications69 citations Open access
Semantic Scholar
Shared genetic contribution to ischemic stroke and Alzheimer's disease
M. Traylor, Poneh Adib-Samii, D. Harold, M. Dichgans +204 more
2016Annals of Neurology69 citations Open access
Semantic Scholar
Neuroinflammation in dementia with Lewy bodies: a human post-mortem study
Jay Amin, C. Holmes, R. Dorey, E. Tommasino +5 more
2020Translational Psychiatry66 citations Open access
Semantic Scholar
Aβ immunotherapy for Alzheimer’s disease: effects on apoE and cerebral vasculopathy
K. Sakai, D. Boche, Roxana O. Carare, D. A. Johnston +3 more
2014Acta Neuropathologica65 citations
Semantic Scholar
The Edinburgh Consensus: preparing for the advent of disease-modifying therapies for Alzheimer’s disease
C. Ritchie, Tom C. Russ, Sube Banerjee, B. Barber +15 more
2017Alzheimer's Research & Therapy62 citations Open access
Semantic Scholar
Cost‐effectiveness of donepezil and memantine in moderate to severe Alzheimer's disease (the DOMINO‐AD trial)
M. Knapp, D. King, R. Romeo, Jessica Adams +21 more
2016International Journal of Geriatric Psychiatry59 citations Open access
Semantic Scholar
Cost-effectiveness analyses for mirtazapine and sertraline in dementia: randomised controlled trial
R. Romeo, Martin Knapp, J. Hellier, M. Dewey +20 more
2013British Journal of Psychiatry58 citations Open access
Semantic Scholar
Inflammation and dementia: Using rheumatoid arthritis as a model to develop treatments?
A. Mason, C. Holmes, C. Edwards
2018Autoimmunity Reviews55 citations
Semantic Scholar
Male Sex Hormones and Systemic Inflammation in Alzheimer Disease
J. Butchart, B. Birch, R. Bassily, L. Wolfe +1 more
2013Alzheimer Disease and Associated Disorders55 citations
Semantic Scholar
Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer’s subjects?
G. Femminella, Nicholas R. Livingston, Sanara Raza, T. F. van der Doef +37 more
2021Alzheimer's Research & Therapy53 citations Open access
Semantic Scholar
Microglial motility in Alzheimer’s disease and after Aβ42 immunotherapy: a human post-mortem study
Diana K. Franco-Bocanegra, B. George, L. Lau, C. Holmes +2 more
2019Acta Neuropathologica Communications48 citations Open access
Semantic Scholar
Effect of active Aβ immunotherapy on neurons in human Alzheimer's disease
C. Paquet, Jay Amin, F. Mouton-Liger, M. Nasser +7 more
2015Journal of Pathology45 citations
Semantic Scholar
Downregulated apoptosis and autophagy after anti‐Aβ immunotherapy in Alzheimer's disease
C. Paquet, J. Nicoll, S. Love, F. Mouton-Liger +3 more
2018Brain Pathology37 citations Open access
Semantic Scholar
Systemic and Central Immunity in Alzheimer's Disease: Therapeutic Implications
J. Butchart, C. Holmes
2012CNS Neuroscience & Therapeutics36 citations Open access
Semantic Scholar
Psychological stress, cognitive decline and the development of dementia in amnestic mild cognitive impairment
R. Sussams, W. Schlotz, Zoe Clough, Jay Amin +9 more
2020Scientific Reports35 citations Open access
Semantic Scholar
Peripheral immunophenotype in dementia with Lewy bodies and Alzheimer’s disease: an observational clinical study
Jay Amin, D. Boche, Zoe Clough, J. Teeling +7 more
2020Journal of Neurology Neurosurgery & Psychiatry35 citations Open access
Semantic Scholar
Prevalence of cognitive impairment in patients with rheumatoid arthritis: a cross sectional study
Bethany McDowell, Calum Marr, C. Holmes, C. Edwards +4 more
2022BMC Psychiatry33 citations Open access
Semantic Scholar
Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer’s disease
E. Baker, R. Sims, G. Leonenko, Aura Frizzati +32 more
2019PLoS ONE31 citations Open access
Semantic Scholar
Persistent neuropathological effects 14 years following amyloid- b immunization in Alzheimer’s disease
J. Nicoll, G. R. Buckland, C. Harrison, Anton M. Page +5 more
201929 citations
Semantic Scholar
A case-control study of the locus coeruleus degeneration in Alzheimer's disease.
R. Hou, Rebecca C. Beardmore, C. Holmes, C. Osmond +1 more
2021European Neuropsychopharmacology25 citations Open access
Semantic Scholar
Effect of amyloid‐β (Aβ) immunization on hyperphosphorylated tau: a potential role for glycogen synthase kinase (GSK)‐3β
Jay Amin, C. Paquet, A. Baker, A. Asuni +5 more
2015Neuropathology and Applied Neurobiology21 citations
Semantic Scholar
The influence of TNF inhibitors on dementia incidence in patients with rheumatoid arthritis; an analysis from the BSRBR‐RA
B. McGuinness, C. Holmes, A. Mirakhur, L. Kearsley-Fleet +3 more
2018International Journal of Geriatric Psychiatry19 citations Open access
Semantic Scholar
Intravenous immunoglobulin for Alzheimer's disease.
C. Holmes
2013Lancet Neurology19 citations
Semantic Scholar

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