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E. Metzger · SciRah

Researcher profile · Semantic Scholar

E. Metzger

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E. Metzger — researcher profile on SciRah

h-index: 37
Works: 77
Citations: 7,282

Most-cited papers

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
E. Metzger, Melanie Wissmann, Na Yin, J. Müller +5 more
2005Nature1,775 citations
Semantic Scholar
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression
Melanie Wissmann, Na Yin, J. Müller, H. Greschik +8 more
2007Nature Cell Biology609 citations
Semantic Scholar
Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence.
P. Kahl, L. Gullotti, L. Heukamp, Susanne Wolf +8 more
2006Cancer Research478 citations Open access
Semantic Scholar
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy.
J. Schulte, Soyoung Lim, A. Schramm, N. Friedrichs +11 more
2009Cancer Research434 citations Open access
Semantic Scholar
A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.
Yue Zhao, G. Lang, Saya Ito, J. Bonnet +12 more
2008Molecules and Cells404 citations Open access
Semantic Scholar
FHL2, a novel tissue‐specific coactivator of the androgen receptor
J. Müller, U. Isele, E. Metzger, A. Rempel +6 more
2000EMBO Journal343 citations Open access
Semantic Scholar
Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4
E. Metzger, A. Imhof, Dharmeshkumar Patel, P. Kahl +11 more
2010Nature302 citations
Semantic Scholar
Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation
E. Metzger, Na Yin, Melanie Wissmann, Natalia Kunowska +8 more
2008Nature Cell Biology230 citations Open access
Semantic Scholar
The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus
J. Müller, E. Metzger, H. Greschik, A. Bosserhoff +3 more
2002EMBO Journal199 citations Open access
Semantic Scholar
Target-based approach to inhibitors of histone arginine methyltransferases.
Astrid Spannhoff, R. Heinke, Ingo Bauer, P. Trojer +6 more
2007Journal of Medicinal Chemistry148 citations Open access
Semantic Scholar
Impairment of prostate cancer cell growth by a selective and reversible lysine‐specific demethylase 1 inhibitor
D. Willmann, Soyoung Lim, S. Wetzel, E. Metzger +10 more
2012International Journal of Cancer131 citations Open access
Semantic Scholar
Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation
K. Ancelin, L. Syx, M. Borensztein, Noémie Ranisavljevic +9 more
2016eLife126 citations Open access
Semantic Scholar
LSD1 promotes oxidative metabolism of white adipose tissue
D. Duteil, E. Metzger, D. Willmann, P. Karagianni +7 more
2014Nature Communications117 citations Open access
Semantic Scholar
A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer
E. Metzger, J. Müller, S. Ferrari, R. Buettner +1 more
2003EMBO Journal116 citations Open access
Semantic Scholar
Role of nitric oxide in pancreatic tumour growth: in vivo and in vitro studies.
A. Hajri, E. Metzger, F. Vallat, S. Coffy +4 more
1998British Journal of Cancer112 citations Open access
Semantic Scholar
Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1.
Elisabeth-Maria Bissinger, R. Heinke, Astrid Spannhoff, A. Eberlin +8 more
2011Bioorganic & Medicinal Chemistry109 citations Open access
Semantic Scholar
PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor‐α target gene activation by regulating lysine demethylase 1 specificity
S. Nair, B. Nair, V. Cortez, D. Chakravarty +5 more
2010EMBO Reports109 citations Open access
Semantic Scholar
Phosphorylation of LSD1 by PKCα is crucial for circadian rhythmicity and phase resetting.
Hye Jin Nam, Kyungjin Boo, Dongha Kim, Dong-Hee Han +13 more
2014Molecules and Cells97 citations Open access
Semantic Scholar
Focal adhesion kinase interacts with the transcriptional coactivator FHL2 and both are overexpressed in epithelial ovarian cancer.
B. Gabriel, S. Mildenberger, Christian W. Weißer, E. Metzger +3 more
2004Anticancer Research88 citations
Semantic Scholar
Epigenetic regulation of cancer growth by histone demethylases
Soyoung Lim, E. Metzger, R. Schüle, J. Kirfel +1 more
2010International Journal of Cancer83 citations Open access
Semantic Scholar
KDM4 Inhibition Targets Breast Cancer Stem-like Cells.
E. Metzger, Stella S. Stepputtis, J. Strietz, Bogdan-Tiberius Preca +16 more
2017Cancer Research82 citations Open access
Semantic Scholar
Assembly of methylated KDM1A and CHD1 drives androgen receptor–dependent transcription and translocation
E. Metzger, D. Willmann, Joel McMillan, I. Forné +19 more
2016Nature Structural &Molecular Biology78 citations
Semantic Scholar
KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells
E. Metzger, Sheng Wang, Sylvia Urban, D. Willmann +17 more
2019Nature Structural & Molecular Biology75 citations
Semantic Scholar
LSD1 controls metastasis of androgen-independent prostate cancer cells through PXN and LPAR6
A. Ketscher, C. Jilg, D. Willmann, Barbara Hummel +6 more
2014Oncogenesis69 citations Open access
Semantic Scholar
Non-peptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity
Martin L. Schmitt, Alexander-Thomas Hauser, Luca Carlino, Martin Pippel +8 more
2013Journal of Medicinal Chemistry69 citations Open access
Semantic Scholar
CtBP and Associated LSD1 Are Required for Transcriptional Activation by NeuroD1 in Gastrointestinal Endocrine Cells
S. K. Ray, Hui Li, E. Metzger, R. Schüle +1 more
2014Molecular and Cellular Biology67 citations Open access
Semantic Scholar
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
P. Hublitz, Natalia Kunowska, U. Mayer, J. Müller +12 more
2005Genes & Development66 citations Open access
Semantic Scholar
Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells
Dongmei Zhu, Stefanie Hölz, E. Metzger, Mihael Pavlovic +9 more
2014Nature Communications63 citations Open access
Semantic Scholar
LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML
J. Barth, K. Abou-El-Ardat, Denis Dalic, Nina Kurrle +17 more
2019Leukemia62 citations
Semantic Scholar
Experimental in vitro, ex vivo and in vivo models in prostate cancer research
V. Sailer, G. von Amsberg, S. Duensing, J. Kirfel +10 more
2022Nature reviews. Urology60 citations
Semantic Scholar
LSD1 Controls Timely MyoD Expression via MyoD Core Enhancer Transcription.
I. Scionti, S. Hayashi, Sandrine Mouradian, E. Girard +11 more
2017Cell Reports52 citations Open access
Semantic Scholar
Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells
Tinka Haydn, E. Metzger, R. Schuele, S. Fulda
2017Cell Death and Disease52 citations Open access
Semantic Scholar
Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4
Josefina Castex, D. Willmann, Toufike Kanouni, L. Arrigoni +11 more
2017Cell Death and Disease44 citations Open access
Semantic Scholar
Lestaurtinib Inhibits Histone Phosphorylation and Androgen-Dependent Gene Expression in Prostate Cancer Cells
J. Köhler, G. Erlenkamp, A. Eberlin, Tobias Rumpf +5 more
2012PLoS ONE44 citations Open access
Semantic Scholar
SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer
Kerstin Rönsch, S. Jägle, Katja Rose, M. Seidl +9 more
2015Molecular Oncology42 citations Open access
Semantic Scholar
PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells
C. Jilg, A. Ketscher, E. Metzger, Barbara Hummel +10 more
2014OncoTarget39 citations Open access
Semantic Scholar
Virtual Screening of PRK1 Inhibitors: Ensemble Docking, Rescoring Using Binding Free Energy Calculation and QSAR Model Development
Inna Slynko, M. Scharfe, Tobias Rumpf, Julia Eib +4 more
2014Journal of Chemical Information and Modeling37 citations
Semantic Scholar
The expanding world of histone lysine demethylases
E. Metzger, R. Schüle
2007Nature Structural &Molecular Biology37 citations
Semantic Scholar
Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death
H. Baumert, E. Metzger, M. Fahrner, J. George +3 more
2020Cancer Cell International36 citations Open access
Semantic Scholar
Histone demethylation and androgen-dependent transcription.
E. Metzger, Melanie Wissmann, R. Schüle
2006Current Opinion in Genetics and Development31 citations
Semantic Scholar
The Relationship between Total Cloud Lightning Behavior and Radar-Derived Thunderstorm Structure
E. Metzger, W. Nuss
201330 citations Open access
Semantic Scholar
KMT9 Controls Stemness and Growth of Colorectal Cancer
C. Berlin, F. Cottard, D. Willmann, Sylvia Urban +10 more
2021Cancer Research24 citations Open access
Semantic Scholar
Screening Assays for Epigenetic Targets Using Native Histones as Substrates
Alexander-Thomas Hauser, Elisabeth-Maria Bissinger, E. Metzger, A. Repenning +4 more
2012Journal of biomolecular screening18 citations Open access
Semantic Scholar
Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity
Sheng Wang, Sebastian O. Klein, Sylvia Urban, Maximilian Staudt +17 more
2024Nature Communications14 citations Open access
Semantic Scholar
Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD+-Dependent Lysine Deacylase Sirtuin 2.
Arianna Colcerasa, Florian Friedrich, Jelena Melesina, Patrick Moser +14 more
2024Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar
Overexpression of KMT9α Is Associated with Aggressive Basal-like Muscle-Invasive Bladder Cancer
F. Koll, E. Metzger, Jana Hamann, Anna Ramos-Triguero +7 more
2023Cells12 citations Open access
Semantic Scholar
Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate
Martin L. Schmitt, K. Ladwein, Luca Carlino, Johannes Schulz-Fincke +7 more
2014Journal of biomolecular screening11 citations Open access
Semantic Scholar
Identification of Highly Potent Protein Kinase C‐Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing
Inna Slynko, K. Schmidtkunz, Tobias Rumpf, Susan Klaeger +7 more
2016ChemMedChem10 citations
Semantic Scholar
Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1).
D. Ostrovskyi, Tobias Rumpf, Julia Eib, A. Lumbroso +16 more
2016Future Medicinal Chemistry9 citations
Semantic Scholar
KDM4A promotes NEPC progression through regulation of MYC expression
C. Mak, Ming Zhu, Jie Fu, Xin Liang +34 more
2025Cancer Letters7 citations Open access
Semantic Scholar

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