A. Orlova

Most-cited papers

Actin Depolymerizing Factor Stabilizes an Existing State of F-Actin and Can Change the Tilt of F-Actin Subunits
V. Galkin, A. Orlova, N. Lukoyanova, W. Wriggers +1 more
2001Journal of Cell Biology243 citations Open access
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Remodeling of actin filaments by ADF/cofilin proteins
V. Galkin, A. Orlova, D. Kudryashov, A. Solodukhin +3 more
2011Proceedings of the National Academy of Sciences of the United States of America229 citations Open access
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Structural Polymorphism in F-actin
V. Galkin, A. Orlova, G. Schröder, E. Egelman
2010Nature Structural &Molecular Biology197 citations Open access
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A conformational change in the actin subunit can change the flexibility of the actin filament.
A. Orlova, E. Egelman
1993Journal of Molecular Biology191 citations
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Actin Filaments as Tension Sensors
V. Galkin, A. Orlova, E. Egelman
2012Current Biology171 citations Open access
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A change in actin conformation associated with filament instability after Pi release.
L. Belmont, A. Orlova, D. Drubin, E. Egelman
1999Proceedings of the National Academy of Sciences of the United States of America158 citations Open access
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Structural dynamics of F-actin: II. Cooperativity in structural transitions.
A. Orlova, E. Próchniewicz, E. Egelman
1995Journal of Molecular Biology153 citations
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Structural basis for the destabilization of F-actin by phosphate release following ATP hydrolysis.
A. Orlova, E. Egelman
1992Journal of Molecular Biology136 citations
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Near-Atomic Resolution for One State of F-Actin
V. Galkin, A. Orlova, M. Vos, G. Schröder +1 more
2014Structure134 citations Open access
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Salmonella SipA Polymerizes Actin by Stapling Filaments with Nonglobular Protein Arms
M. Lilic, V. Galkin, A. Orlova, M. Vanloock +2 more
2003Science125 citations
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High-resolution cryo-EM structure of the F-actin–fimbrin/plastin ABD2 complex
V. Galkin, A. Orlova, O. Cherepanova, M. Lebart +1 more
2008Proceedings of the National Academy of Sciences of the United States of America121 citations Open access
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Structural dynamics of F-actin: I. Changes in the C terminus.
A. Orlova, E. Egelman
1995Journal of Molecular Biology117 citations
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ADF/cofilin use an intrinsic mode of F-actin instability to disrupt actin filaments
V. Galkin, A. Orlova, M. Vanloock, A. Shvetsov +2 more
2003Journal of Cell Biology109 citations Open access
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A new internal mode in F-actin helps explain the remarkable evolutionary conservation of actin's sequence and structure.
V. Galkin, M. Vanloock, A. Orlova, E. Egelman
2002Current Biology109 citations Open access
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Opening of tandem calponin homology domains regulates their affinity for F-actin
V. Galkin, A. Orlova, A. Salmazo, K. Djinović-Carugo +1 more
2010Nature Structural &Molecular Biology108 citations Open access
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A structural model of flagellar filament switching across multiple bacterial species
Feng-Bin Wang, A. M. Burrage, S. Postel, Reece E Clark +4 more
2017Nature Communications107 citations Open access
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CRYO-ELECTRON MICROSCOPY RECONSTRUCTIONS OF THE PSEUDOMONAS AERUGINOSA AND NEISSERIA GONORRHOEAE TYPE IV PILI AT SUB-NANOMETER RESOLUTION
Feng-Bin Wang, Mathieu Coureuil, T. Osinski, A. Orlova +5 more
2017Structure101 citations Open access
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Cooperative rigor binding of myosin to actin is a function of F-actin structure.
A. Orlova, E. Egelman
1997Journal of Molecular Biology97 citations
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The structure of bacterial ParM filaments
A. Orlova, E. Garner, V. Galkin, J. Heuser +2 more
2007Nature Structural &Molecular Biology90 citations Open access
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The utrophin actin-binding domain binds F-actin in two different modes
V. Galkin, A. Orlova, M. Vanloock, I. Rybakova +2 more
2002Journal of Cell Biology90 citations Open access
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New insights into actin filament dynamics.
E. Egelman, A. Orlova
1995Current Opinion in Structural Biology82 citations
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Actin-destabilizing factors disrupt filaments by means of a time reversal of polymerization.
A. Orlova, A. Shvetsov, V. Galkin, D. Kudryashov +3 more
2004Proceedings of the National Academy of Sciences of the United States of America80 citations Open access
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Mapping of Drebrin Binding Site on F-Actin
Elena E. Grintsevich, V. Galkin, A. Orlova, A. Ytterberg +5 more
2010Journal of Molecular Biology71 citations Open access
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Each actin subunit has three nebulin binding sites: implications for steric blocking.
N. Lukoyanova, M. Vanloock, A. Orlova, V. Galkin +2 more
2002Current Biology70 citations Open access
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The bacterial protein SipA polymerizes G-actin and mimics muscle nebulin
V. Galkin, A. Orlova, M. Vanloock, Dao-Guo Zhou +2 more
2002Nature Structural Biology67 citations
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Direct interaction of actin filaments with F‐BAR protein pacsin2
J. Kostan, U. Salzer, A. Orlova, Imre Törö +15 more
2014EMBO Reports62 citations Open access
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Probing the structure of F-actin: cross-links constrain atomic models and modify actin dynamics.
A. Orlova, V. Galkin, M. Vanloock, Eldar Kim +3 more
2001Journal of Molecular Biology60 citations
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Coronin-1A stabilizes F-actin by bridging adjacent actin protomers and stapling opposite strands of the actin filament.
V. Galkin, A. Orlova, W. Brieher, H. Kueh +2 more
2008Journal of Molecular Biology56 citations Open access
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The N-terminal Domains of Myosin Binding Protein C Can Bind Polymorphically to F-Actin
A. Orlova, V. Galkin, C. Jeffries, E. Egelman +1 more
2011Journal of Molecular Biology55 citations Open access
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Identification of a new actin binding surface on vinculin that mediates mechanical cell and focal adhesion properties
Peter M. Thompson, Caitlin E. Tolbert, K. Shen, Pradeep Kota +9 more
2014Structure53 citations Open access
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Modulation of yeast F-actin structure by a mutation in the nucleotide-binding cleft.
A. Orlova, Xin Chen, Peter A. Rubenstein, E. Egelman
1997Journal of Molecular Biology50 citations
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Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation
Adam W. Avery, Michael E. Fealey, Feng-Bin Wang, A. Orlova +4 more
2017Nature Communications48 citations Open access
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The CH-domain of calponin does not determine the modes of calponin binding to F-actin.
V. Galkin, A. Orlova, A. Fattoum, M. Walsh +1 more
2006Journal of Molecular Biology47 citations
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Intrastrand cross-linked actin between Gln-41 and Cys-374. III. Inhibition of motion and force generation with myosin.
Eldar Kim, E. Bobkova, Carl J. Miller, A. Orlova +4 more
1998Biochemistry46 citations
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Structural Polymorphism of the ParM Filament and Dynamic Instability
V. Galkin, A. Orlova, C. Rivera, R. D. Mullins +1 more
2009Structure43 citations Open access
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Do the utrophin tandem calponin homology domains bind F-actin in a compact or extended conformation?
V. Galkin, A. Orlova, M. Vanloock, E. Egelman
2003Journal of Molecular Biology42 citations
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Cofilin cross-bridges adjacent actin protomers and replaces part of the longitudinal F-actin interface.
D. Kudryashov, V. Galkin, A. Orlova, M. Phan +2 more
2006Journal of Molecular Biology40 citations
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A NOVEL THICK FILAMENT PROTEIN IN SMOOTH MUSCLES OF BIVALVE MOLLUSCS
N. S. Shelud'ko, K. Tuturova, T. V. Permyakova, S. V. Plotnikov +1 more
199935 citations
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Allostery, cooperativity, and different structural states in F-actin.
Edward H. Egelman, A. Orlova
1995Journal of Structural Biology35 citations
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Ambidextrous helical nanotubes from self-assembly of designed helical hairpin motifs
Spencer A. Hughes, Feng-Bin Wang, Shengyuan Wang, Mark A. B. Kreutzberger +6 more
2019Proceedings of the National Academy of Sciences of the United States of America33 citations Open access
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Xin-repeats and nebulin-like repeats bind to F-actin in a similar manner.
O. Cherepanova, A. Orlova, V. Galkin, P. F. M. van der Ven +3 more
2006Journal of Molecular Biology29 citations
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Three-dimensional reconstruction of a co-complex of F-actin with antibody Fab fragments to actin's NH2 terminus.
A. Orlova, Xiong Yu, E. Egelman
1994Biophysical Journal27 citations Open access
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Actin Polymerization is Stimulated by Actin Crosslinking Protein Palladin
R. Gurung, R. Yadav, J. Brungardt, A. Orlova +2 more
2015Biochemical Journal26 citations Open access
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The Arg non-receptor tyrosine kinase modifies F-actin structure.
V. Galkin, A. Orlova, A. Koleske, E. Egelman
2005Journal of Molecular Biology26 citations
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Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation
Adam W. Avery, Michael E. Fealey, Feng-Bin Wang, A. Orlova +4 more
2017Nature Communications25 citations Open access
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F-actin retains a memory of angular order.
A. Orlova, E. Egelman
2000Biophysical Journal23 citations Open access
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Binding of dystrophin's tandem calponin homology domain to F-actin is modulated by actin's structure.
A. Orlova, I. Rybakova, E. Próchniewicz, David D. Thomas +2 more
2001Biophysical Journal22 citations Open access
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Actin hydrophobic loop 262-274 and filament nucleation and elongation.
A. Shvetsov, V. Galkin, A. Orlova, M. Phillips +4 more
2008Journal of Molecular Biology19 citations Open access
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The location of ubiquitin in Lethocerus arthrin.
V. Galkin, A. Orlova, N. Lukoyanova, M. Vanloock +3 more
2003Journal of Molecular Biology18 citations
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Archaeal actin from a hyperthermophile forms a single-stranded filament
T. Braun, A. Orlova, K. Valegård, A. Lindås +2 more
2015Proceedings of the National Academy of Sciences of the United States of America17 citations Open access
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