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S. Pérez-Silanes · SciRah

Researcher profile · Semantic Scholar

S. Pérez-Silanes

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S. Pérez-Silanes — researcher profile on SciRah

h-index: 30
Works: 76
Citations: 2,192

Most-cited papers

Synthesis and anti-inflammatory/antioxidant activities of some new ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1H)-pyrazole analogues.
A. Burguete, E. Pontiki, D. Hadjipavlou-Litina, R. Villar +6 more
2007Bioorganic & Medicinal Chemistry Letters139 citations Open access
Semantic Scholar
Synthesis and antimycobacterial activity of new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives.
E. Moreno, Saioa Ancizu, S. Pérez-Silanes, Enrique Torres +2 more
2003European journal of medicinal chemistry120 citations Open access
Semantic Scholar
Selective activity against Mycobacteriumtuberculosis of new quinoxaline 1,4-di-N-oxides.
E. Vicente, S. Pérez-Silanes, L. M. Lima, Saioa Ancizu +5 more
2009Bioorganic & Medicinal Chemistry111 citations
Semantic Scholar
Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates.
N. Romeiro, Gabriela Aguirre, Paola Hernández, Mercedes González +6 more
2009Bioorganic & Medicinal Chemistry101 citations
Semantic Scholar
Novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action.
Luis Berrade, B. Aisa, M. J. Ramírez, Silvia Galiano +9 more
2011Journal of Medicinal Chemistry98 citations Open access
Semantic Scholar
New 3-methylquinoxaline-2-carboxamide 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents.
Saioa Ancizu, E. Moreno, B. Solano, R. Villar +5 more
2010Bioorganic & Medicinal Chemistry74 citations Open access
Semantic Scholar
New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterium tuberculosis agents.
Enrique Torres, E. Moreno, Saioa Ancizu, C. Barea +4 more
2011Bioorganic & Medicinal Chemistry Letters72 citations Open access
Semantic Scholar
The role of imidazole and benzimidazole heterocycles in Chagas disease: A review.
Iván Beltrán-Hortelano, Verónica Alcolea, M. Font, S. Pérez-Silanes
2020European journal of medicinal chemistry69 citations Open access
Semantic Scholar
Synthesis and structure-activity relationship of 3-phenylquinoxaline 1,4-di-N-oxide derivatives as antimalarial agents.
E. Vicente, L. M. Lima, E. Bongard, Sarah C. Charnaud +7 more
2008European journal of medicinal chemistry60 citations
Semantic Scholar
New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.
Javier Martínez-Esparza, A. Oficialdegui, S. Pérez-Silanes, B. Heras +10 more
2001Journal of Medicinal Chemistry60 citations Open access
Semantic Scholar
Challenges in Chagas Disease Drug Discovery: A Review.
R. Paucar, Elsa Moreno-Viguri, S. Pérez-Silanes
2016Current Medicinal Chemistry54 citations Open access
Semantic Scholar
3-Trifluoromethylquinoxaline N,N'-dioxides as anti-trypanosomatid agents. Identification of optimal anti-T. cruzi agents and mechanism of action studies.
D. Benítez, Mauricio Cabrera, Paola Hernández, L. Boiani +16 more
2011Journal of Medicinal Chemistry54 citations Open access
Semantic Scholar
New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities.
C. Barea, Adriana Pabón, D. Castillo, M. Zimić +6 more
2011Bioorganic & Medicinal Chemistry Letters54 citations Open access
Semantic Scholar
Trypanothione Reductase and Superoxide Dismutase as Current Drug Targets for Trypanosoma cruzi: An Overview of Compounds with Activity against Chagas Disease.
Iván Beltrán-Hortelano, S. Pérez-Silanes, Silvia Galiano
2017Current Medicinal Chemistry53 citations
Semantic Scholar
Synthesis and biological evaluation of new 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives and their reduced analogues.
B. Solano, Venkatraman Junnotula, Adoración Marín, R. Villar +8 more
2007Journal of Medicinal Chemistry53 citations
Semantic Scholar
Examination of multiple Trypanosoma cruzi targets in a new drug discovery approach for Chagas disease.
Iván Beltrán-Hortelano, Verónica Alcolea, M. Font, S. Pérez-Silanes
2022Bioorganic & Medicinal Chemistry49 citations Open access
Semantic Scholar
In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide.
R. Villar, E. Vicente, B. Solano, S. Pérez-Silanes +7 more
2008Journal of Antimicrobial Chemotherapy49 citations Open access
Semantic Scholar
Efficacy of Quinoxaline-2-Carboxylate 1,4-Di-N-Oxide Derivatives in Experimental Tuberculosis
E. Vicente, R. Villar, A. Burguete, B. Solano +8 more
2008Antimicrobial Agents and Chemotherapy49 citations Open access
Semantic Scholar
Heterocyclic-2-carboxylic Acid (3-Cyano-1,4-di-N-oxidequinoxalin-2-yl)amide Derivatives as Hits for the Development of Neglected Disease Drugs
Saioa Ancizu, E. Moreno, Enrique Torres, A. Burguete +9 more
2009Molecules47 citations Open access
Semantic Scholar
Synthesis and Molecular Modeling of New 1-Aryl-3-[4-arylpiperazin-1-yl]-1-propane Derivatives with High Affinity at the Serotonin Transporter and at 5-HT1A Receptors
L. Orús, S. Pérez-Silanes, A. Oficialdegui, Javier Martínez-Esparza +13 more
200246 citations Open access
Semantic Scholar
Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents.
Enrique Torres, Elsa Moreno-Viguri, Silvia Galiano, Goutham Devarapally +11 more
2013European journal of medicinal chemistry43 citations Open access
Semantic Scholar
Trypanocidal properties, structure-activity relationship and computational studies of quinoxaline 1,4-di-N-oxide derivatives.
Y. Estevez, Miguel Quiliano, A. Burguete, B. Cabanillas +8 more
2011Experimental parasitology43 citations Open access
Semantic Scholar
Synthesis, Biological Evaluation and Structure-Activity Relationships of New Quinoxaline Derivatives as Anti-Plasmodium falciparum Agents
A. Gil, Adriana Pabón, Silvia Galiano, A. Burguete +4 more
2014Molecules36 citations Open access
Semantic Scholar
Second Generation of Mannich Base-Type Derivatives with in Vivo Activity against Trypanosoma cruzi.
Rubén Martín-Escolano, Elsa Moreno-Viguri, Mery Santivañez-Veliz, Á. Martín-Montes +8 more
2018Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
New Amide Derivatives of Quinoxaline 1,4-di-N-Oxide with Leishmanicidal and Antiplasmodial Activities
C. Barea, Adriana Pabón, S. Pérez-Silanes, Silvia Galiano +4 more
2013Molecules35 citations Open access
Semantic Scholar
1,4-Di-N-oxide quinoxaline-2-carboxamide: Cyclic voltammetry and relationship between electrochemical behavior, structure and anti-tuberculosis activity
E. Moreno, S. Pérez-Silanes, Shravani Gouravaram, Abinav Macharam +5 more
201135 citations Open access
Semantic Scholar
Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives
C. Barea, Adriana Pabón, Silvia Galiano, S. Pérez-Silanes +5 more
2012Molecules33 citations Open access
Semantic Scholar
Synthesis and Antiplasmodial Activity of 3-Furyl and 3-Thienylquinoxaline-2-carbonitrile 1,4-Di-N-oxide Derivatives
E. Vicente, Sarah C. Charnaud, E. Bongard, R. Villar +7 more
2008Molecules33 citations Open access
Semantic Scholar
In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives.
Elsa Moreno-Viguri, Carmen Jiménez-Montes, Rubén Martín-Escolano, Mery Santivañez-Veliz +9 more
2016Journal of Medicinal Chemistry32 citations Open access
Semantic Scholar
Quinoxaline 1,4-di-N-oxide and the potential for treating tuberculosis.
E. Vicente, R. Villar, S. Pérez-Silanes, I. Aldana +2 more
2011Infectious Diseases - Drug Targets32 citations Open access
Semantic Scholar
Library of Seleno-Compounds as Novel Agents against Leishmania Species
Á. Martín-Montes, D. Plano, Rubén Martín-Escolano, Verónica Alcolea +8 more
2017Antimicrobial Agents and Chemotherapy30 citations Open access
Semantic Scholar
Aryl piperazine and pyrrolidine as antimalarial agents. Synthesis and investigation of structure-activity relationships.
A. Mendoza, S. Pérez-Silanes, Miguel Quiliano, Adriana Pabón +8 more
2011Experimental parasitology30 citations Open access
Semantic Scholar
Organometallic compounds in the discovery of new agents against kinetoplastid-caused diseases.
M. Ravera, Elsa Moreno-Viguri, R. Paucar, S. Pérez-Silanes +1 more
2018European journal of medicinal chemistry28 citations
Semantic Scholar
Design and synthesis of novel quinoxaline derivatives as potential candidates for treatment of multidrug-resistant and latent tuberculosis
Mery Santivañez-Veliz, S. Pérez-Silanes, Enrique Torres, Elsa Moreno-Viguri
2016Bioorganic & Medicinal Chemistry Letters27 citations Open access
Semantic Scholar
Selenium as an interesting option for the treatment of Chagas disease: A review.
Verónica Alcolea, S. Pérez-Silanes
2020European journal of medicinal chemistry26 citations
Semantic Scholar
Exploring the scope of new arylamino alcohol derivatives: Synthesis, antimalarial evaluation, toxicological studies, and target exploration
Miguel Quiliano, A. Mendoza, Kim Y. Fong, Adriana Pabón +11 more
2016International Journal for Parasitology: Drugs and Drug Resistance21 citations Open access
Semantic Scholar
Rational modification of Mannich base-type derivatives as novel antichagasic compounds: Synthesis, in vitro and in vivo evaluation.
R. Paucar, Rubén Martín-Escolano, Elsa Moreno-Viguri, A. Azqueta +4 more
2019Bioorganic & Medicinal Chemistry20 citations Open access
Semantic Scholar
Synthesis of new 5‐substitutedbenzo[b]thiophene derivatives
S. Pérez-Silanes, Javier Martínez-Esparza, A. Oficialdegui, H. Villanueva +2 more
200119 citations
Semantic Scholar
Synthesis and biological evaluation of quinoxaline di-N-oxide derivatives with in vitro trypanocidal activity.
S. Pérez-Silanes, Enrique Torres, L. Arbillaga, J. Varela +4 more
2016Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
New 1-Aryl-3-Substituted Propanol Derivatives as Antimalarial Agents
S. Pérez-Silanes, Luis Berrade, R. García-Sánchez, A. Mendoza +6 more
2009Molecules18 citations Open access
Semantic Scholar
Novel sulfonylurea derivatives as H3 receptor antagonists. Preliminary SAR studies.
Javier Ceras, N. Cirauqui, S. Pérez-Silanes, I. Aldana +2 more
2012European journal of medicinal chemistry17 citations Open access
Semantic Scholar
Design and synthesis of Mannich base-type derivatives containing imidazole and benzimidazole as lead compounds for drug discovery in Chagas Disease.
Iván Beltrán-Hortelano, Richard L. Atherton, Mercedes Rubio-Hernández, J. Sanz-Serrano +4 more
2021European journal of medicinal chemistry14 citations Open access
Semantic Scholar
In vitro antileishmanial activity and iron superoxide dismutase inhibition of arylamine Mannich base derivatives
Á. Martín-Montes, Mery Santivañez-Veliz, Elsa Moreno-Viguri, Rubén Martín-Escolano +7 more
2017Parasitology14 citations Open access
Semantic Scholar
Quinoxaline 1,4-di-N-oxide derivatives: Interest in the treatment of Chagas disease
Elsa Moreno-Viguri, S. Pérez-Silanes
201313 citations Open access
Semantic Scholar
Studies on Log Po/w of Quinoxaline di-N-Oxides: A Comparison of RP-HPLC Experimental and Predictive Approaches
E. Moreno, E. Gabano, Enrique Torres, J. Platts +4 more
2011Molecules13 citations Open access
Semantic Scholar
Neglected Zoonotic Diseases: Advances in the Development of Cell-Penetrating and Antimicrobial Peptides against Leishmaniosis and Chagas Disease
S. Robledo, S. Pérez-Silanes, Celia Fernández-Rubio, A. Poveda +4 more
2023Pathogens12 citations Open access
Semantic Scholar
A step towards development of promising trypanocidal agents: Synthesis, characterization and in vitro biological evaluation of ferrocenyl Mannich base-type derivatives.
R. Paucar, Rubén Martín-Escolano, Elsa Moreno-Viguri, N. Cirauqui +6 more
2019European journal of medicinal chemistry12 citations
Semantic Scholar
Potential of sulfur-selenium isosteric replacement as a strategy for the development of new anti-chagasic drugs.
Mercedes Rubio-Hernández, Verónica Alcolea, S. Pérez-Silanes
2022Acta Tropica11 citations Open access
Semantic Scholar
New Quinoxaline Derivatives as Potential MT1 and MT2 Receptor Ligands
Saioa Ancizu, Nerea Castrillo, S. Pérez-Silanes, I. Aldana +4 more
2012Molecules10 citations Open access
Semantic Scholar
Development, validation and application of a GC-MS method for the simultaneous detection and quantification of neutral lipid species in Trypanosoma cruzi.
Mery Santivañez-Veliz, Elsa Moreno-Viguri, S. Pérez-Silanes, J. Varela +3 more
2017Journal of chromatography. B, Analytical technologies in the biomedical and life sciences9 citations Open access
Semantic Scholar

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