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H. J. Jürgensen · SciRah

Researcher profile · Semantic Scholar

H. J. Jürgensen

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H. J. Jürgensen — researcher profile on SciRah

h-index: 20
Works: 35
Citations: 1,452

Most-cited papers

M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway
D. H. Madsen, D. Leonard, Andrius Masedunskas, A. Moyer +12 more
2013Journal of Cell Biology331 citations Open access
Semantic Scholar
Tumor-associated macrophages derived from circulating inflammatory monocytes degrade collagen through cellular uptake
D. H. Madsen, H. J. Jürgensen, Majken Siersbæk, D. Kuczek +6 more
2017Cell Reports140 citations Open access
Semantic Scholar
The Non-phagocytic Route of Collagen Uptake
D. H. Madsen, Signe Z Ingvarsen, H. J. Jürgensen, Maria C. Melander +9 more
2011Journal of Biological Chemistry113 citations Open access
Semantic Scholar
A Novel Functional Role of Collagen Glycosylation
H. J. Jürgensen, D. H. Madsen, Signe Z Ingvarsen, Maria C. Melander +4 more
2011Journal of Biological Chemistry86 citations Open access
Semantic Scholar
Ficolin-1–PTX3 Complex Formation Promotes Clearance of Altered Self-Cells and Modulates IL-8 Production
Ying-Jie Ma, A. Doni, L. Romani, H. J. Jürgensen +3 more
2013Journal of Immunology77 citations Open access
Semantic Scholar
The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)
Maria C. Melander, H. J. Jürgensen, D. H. Madsen, L. Engelholm +1 more
2015International Journal of Oncology71 citations Open access
Semantic Scholar
The collagen receptor uPARAP/Endo180.
L. Engelholm, Signe Z Ingvarsen, H. J. Jürgensen, Thore Hillig +3 more
2009Frontiers in Bioscience58 citations Open access
Semantic Scholar
Targeting a Single Function of the Multifunctional Matrix Metalloprotease MT1-MMP
Signe Z Ingvarsen, Astrid Porse, Charlotte Erpicum, Ludovic Maertens +9 more
2013Journal of Biological Chemistry55 citations Open access
Semantic Scholar
Complex Determinants in Specific Members of the Mannose Receptor Family Govern Collagen Endocytosis*
H. J. Jürgensen, Kristina Johansson, D. H. Madsen, Astrid Porse +6 more
2014Journal of Biological Chemistry52 citations Open access
Semantic Scholar
Endocytic collagen degradation: a novel mechanism involved in protection against liver fibrosis
D. H. Madsen, H. J. Jürgensen, Signe Z Ingvarsen, Maria C. Melander +8 more
2012Journal of Pathology52 citations Open access
Semantic Scholar
Osteosarcoma and Metastasis Associated Bone Degradation—A Tale of Osteoclast and Malignant Cell Cooperativity
K. Nørregaard, H. J. Jürgensen, H. Gårdsvoll, L. Engelholm +2 more
2021International Journal of Molecular Sciences48 citations Open access
Semantic Scholar
A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo.
M. Motley, D. H. Madsen, H. J. Jürgensen, David E. Spencer +7 more
2016Blood46 citations Open access
Semantic Scholar
Uncovering mediators of collagen degradation in the tumor microenvironment
Marie-Louise Thorseth, M. Carretta, C. Jensen, Kasper Mølgaard +5 more
2022Matrix Biology Plus39 citations Open access
Semantic Scholar
Cellular uptake of collagens and implications for immune cell regulation in disease
H. J. Jürgensen, S. V. van Putten, K. Nørregaard, T. Bugge +3 more
2020Cellular and Molecular Life Sciences38 citations Open access
Semantic Scholar
The collagen receptor uPARAP/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers
Christoffer Nielsen, S. V. van Putten, I. Lund, Maria C. Melander +10 more
2017OncoTarget34 citations Open access
Semantic Scholar
Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180
Lars H. Engelholm, Maria C. Melander, Andreas Hald, Morten Persson +12 more
2016Journal of Pathology34 citations
Semantic Scholar
Differential Actions of the Endocytic Collagen Receptor uPARAP/Endo180 and the Collagenase MMP-2 in Bone Homeostasis
D. H. Madsen, H. J. Jürgensen, Signe Z Ingvarsen, Maria C. Melander +6 more
2013PLoS ONE31 citations Open access
Semantic Scholar
CCL2/MCP-1 signaling drives extracellular matrix turnover by diverse macrophage subsets
H. J. Jürgensen, L. M. Silva, O. Krigslund, S. V. van Putten +4 more
2019Matrix Biology Plus26 citations Open access
Semantic Scholar
Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis
Signe Z Ingvarsen, H. Gårdsvoll, S. V. van Putten, K. Nørregaard +10 more
2020Scientific Reports24 citations Open access
Semantic Scholar
Matriptase zymogen supports epithelial development, homeostasis and regeneration
S. Friis, Daniel Tadeo, S. le Gall, H. J. Jürgensen +3 more
2017BMC Biology20 citations Open access
Semantic Scholar
Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins
H. J. Jürgensen, K. Nørregaard, Megan Sibree, E. Santoni-Rugiu +7 more
2018Journal of Cell Biology19 citations Open access
Semantic Scholar
Targeting uPAR with an antibody-drug conjugate suppresses tumor growth and reshapes the immune landscape in pancreatic cancer models
Virginia Metrangolo, Michaela Hansen Blomquist, Ananya Dutta, H. Gårdsvoll +7 more
2025Science Advances17 citations Open access
Semantic Scholar
Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding.
C. Yuan, H. J. Jürgensen, L. Engelholm, Rui Li +5 more
2016Biochemical Journal12 citations
Semantic Scholar
The collagen receptor uPARAP/Endo180 regulates collectins through unique structural elements in its FNII domain
K. Nørregaard, O. Krigslund, N. Behrendt, L. Engelholm +1 more
2020Journal of Biological Chemistry9 citations Open access
Semantic Scholar
The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target
Pınar Çakılkaya, Rikke Sørensen, H. J. Jürgensen, O. Krigslund +5 more
2021International Journal of Molecular Sciences7 citations Open access
Semantic Scholar
The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1.
K. Nørregaard, H. J. Jürgensen, Signe Z Ingvarsen, S. S. Hansen +6 more
2022Matrix Biology6 citations Open access
Semantic Scholar
The Recycling Collagen Receptor uPARAP Is a Unique Mediator of Stromal Drug Delivery to Carcinoma Cells
K. Nørregaard, Ida M E Larsen, H. J. Jürgensen, Michaela Hansen Blomquist +10 more
2025Molecular Cancer Therapeutics4 citations Open access
Semantic Scholar
A proteomics-based survey reveals thrombospondin-4 as a ligand regulated by the mannose receptor in the injured lung
K. Nørregaard, H. J. Jürgensen, S. S. Heltberg, H. Gårdsvoll +4 more
2024Journal of Biological Chemistry1 citations Open access
Semantic Scholar
Matriptase zymogen supports epithelial development, homeostasis and regeneration
S. Friis, Daniel Tadeo, S. le Gall, H. J. Jürgensen +3 more
2017BMC Biology1 citations Open access
Semantic Scholar
THROMBOSIS AND HEMOSTASIS A CCR 2 macrophage endocytic pathway mediates extravascular fi brin clearance in vivo
M. Motley, D. H. Madsen, H. J. Jürgensen, David E. Spencer +7 more
20161 citations
Semantic Scholar
Abstract 5659: Unveiling the PanCancer potential of dual-targeting uPAR-directed ADCs across cancers.
Virginia Metrangolo, L. Engelholm, H. J. Jürgensen, Sine R. Syversen +1 more
2026Cancer Research0 citations
Semantic Scholar
Collagen type I promotes pancreatic tumor growth and limits immune cell infiltration
Marie-Louise Thorseth, A. Z. Johansen, K. J. Baker, M. Carretta +13 more
2026bioRxiv0 citations Open access
Semantic Scholar
Cytokine conversations: Fibroblasts shape macrophage identity to enhance collagen clearance.
S. S. Heltberg, S. V. van Putten, O. Krigslund, K. Nørregaard +4 more
2026Matrix Biology0 citations Open access
Semantic Scholar
Targeting uPARAP with an Antibody–Drug Conjugate Exhibits Efficacy against Mesothelioma and Synergizes with Cisplatin
Pınar Çakılkaya, Ida Marie Egeland Larsen, Qun Jiang, K. Nørregaard +10 more
2025Cancer Research Communications0 citations Open access
Semantic Scholar
Antibodies for targeting of collagenolytic processes
L. Engelholm, D. H. Madsen, Signe Z Ingvarsen, H. J. Jürgensen +2 more
20080 citations
Semantic Scholar

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L. Engelholm×27
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L. Engelholm — researcher profile on SciRah
N. Behrendt×24
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N. Behrendt — researcher profile on SciRah
D. H. Madsen×19
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T. Bugge×16
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×12

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Signe Z Ingvarsen×10

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Maria C. Melander×10

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H. Gårdsvoll×9

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O. Krigslund×8

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Kenn Holmbeck×6

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S. V. van Putten×5

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