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Bina Desai · SciRah

Researcher profile · Semantic Scholar

Bina Desai

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Bina Desai — researcher profile on SciRah

h-index: 8
Works: 47
Citations: 390

Most-cited papers

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures
Robert J. Vander Velde, N. Yoon, Viktoriya Marusyk, Arda Durmaz +14 more
2020Nature Communications120 citations Open access
Semantic Scholar
IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells
L. L. Remsing Rix, N. Sumi, Q. Hu, Bina Desai +13 more
2022Science Signaling72 citations Open access
Semantic Scholar
A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization
P. Wojnarowicz, R. L. Silva, Masayuki Ohnaka, Sang Bae Lee +29 more
2019Cell Reports45 citations Open access
Semantic Scholar
Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures
Robert J. Vander Velde, N. Yoon, Viktoriya Marusyk, Arda Durmaz +14 more
2020Nature Communications30 citations Open access
Semantic Scholar
Omega-3 Fatty Acid Grafted PAMAM-Paclitaxel Conjugate Exhibits Enhanced Anticancer Activity in Upper Gastrointestinal Cancer Cells.
Tanmay Dichwalkar, Shraddha Patel, S. Bapat, P. Pancholi +4 more
2017Macromolecular Bioscience25 citations
Semantic Scholar
Anti-tumor effects of an ID antagonist with no observed acquired resistance
P. Wojnarowicz, Marta García Escolano, Yun-Han Huang, Bina Desai +23 more
2021npj Breast Cancer24 citations Open access
Semantic Scholar
Resistance to ALK targeting therapies as a gradual Darwinian adaptation to inhibitor specific selective pressures
R. V. Velde, N. Yoon, Viktoriya Marusyk, Arda Durmaz +13 more
2018bioRxiv12 citations Open access
Semantic Scholar
RAS-GTP Inhibition Overcomes Acquired Resistance to KRASG12C Inhibitors Mediated by Oncogenic and Wildtype RAS Activation in Non-Small Cell Lung Cancer
Hitendra S. Solanki, Harshit Shah, Denis Imbody, Bina Desai +20 more
2025Cancer Research9 citations Open access
Semantic Scholar
Dissecting the Spatially Restricted Effects of Microenvironment-Mediated Resistance on Targeted Therapy Responses
Tatiana Miti, Bina Desai, D. Miroshnychenko, D. Basanta +1 more
2024Cancers7 citations Open access
Semantic Scholar
Peristromal niches protect lung cancers from targeted therapies through a combined effect of multiple molecular mediators
Bina Desai, Tatiana Miti, Sandhya Prabhakaran, D. Miroshnychenko +10 more
2024bioRxiv5 citations Open access
Semantic Scholar
In situ RAS:RAF binding correlates with response to KRASG12C inhibitors in KRASG12C-mutant non–small cell lung cancer
Ryoji Kato, Hitendra S. Solanki, Hilal Ozakinci, Bina Desai +8 more
2025Clinical Cancer Research4 citations Open access
Semantic Scholar
Anti-tumor effects of an Id antagonist with no acquired resistance
P. Wojnarowicz, Marta García Escolano, Yun-Han Huang, Bina Desai +19 more
2020bioRxiv4 citations Open access
Semantic Scholar
Understanding the Evolutionary Games in NSCLC Microenvironment
Ranjini Bhattacharya, R. V. Velde, Viktoriya Marusyk, Bina Desai +3 more
2020bioRxiv4 citations Open access
Semantic Scholar
Evolutionary Double-Bind Treatment Using Radiation Therapy and Natural Killer Cell-Based Immunotherapy in Prostate Cancer
K. Luddy, Jeffrey West, M. Robertson-Tessi, Bina Desai +11 more
2025International Journal of Radiation Oncology, Biology, Physics3 citations
Semantic Scholar
Cancer-associated fibroblasts confer ALK inhibitor resistance in EML4-ALK-driven lung cancer by concurrent integrin and MET signaling.
Qianqian Hu, L. L. Remsing Rix, Bina Desai, D. Miroshnychenko +11 more
2025Science Signaling3 citations Open access
Semantic Scholar
Trastuzumab Deruxtecan Combination Strongly Enhances Responses and Overcomes Sotorasib Resistance in KRASG12C-Mutant NSCLC
Hilal Ozakinci, Bina Desai, D. Kalos, Dung-Tsa Chen +8 more
2024bioRxiv3 citations Open access
Semantic Scholar
Cancer-associated fibroblasts confer ALK inhibitor resistance in EML4-ALK-driven lung cancer via concurrent integrin and MET signaling
Q. Hu, L. L. Remsing Rix, Bina Desai, D. Miroshnychenko +11 more
2024bioRxiv3 citations Open access
Semantic Scholar
Selective targeting of M3 muscarinic receptors: an opportunity for improved treatment of upper gastrointestinal carcinomas
Justine M. Betzu, Neel Jasani, Bina Desai, Vikas Sehdev
20143 citations Open access
Semantic Scholar
Pre-clinical efficacy of trastuzumab deruxtecan plus sotorasib in KRASG12C-mutant non-small cell lung cancer and exploratory HER2 profiling in human tumors
Hilal Ozakinci, Bina Desai, D. Kalos, Dung-Tsa Chen +8 more
2026Translational Lung Cancer Research2 citations Open access
Semantic Scholar
Multifactorial stroma-mediated resistance is a major contributor to residual disease under targeted therapies in lung cancers
Bina Desai, Tatiana Miti, Sandhya Prabhakaran, D. Miroshnychenko +13 more
2025Research Square2 citations Open access
Semantic Scholar
Evolutionary double-bind treatment using radiotherapy and NK cell-based immunotherapy in prostate cancer
K. Luddy, Jeffrey West, M. Robertson-Tessi, Bina Desai +8 more
2024bioRxiv2 citations Open access
Semantic Scholar
Abstract B008: Therapy-protective peristromal niches mediate positive ecological interaction between therapy-sensitive and therapy-resistant cells, altering the evolutionary dynamics of acquired targeted therapy resistance in lung cancers
M. Robertson-Tessi, Bina Desai, Tatiana Miti, Pragya Kumar +7 more
2024Cancer Research2 citations
Semantic Scholar
Multifactorial sheltering in peristromal niches shapes in vivo responses of lung cancers to targeted therapies
Bina Desai, Tatiana Miti, Sandhya Prabhakaran, D. Miroshnychenko +15 more
2026Nature Communications1 citations Open access
Semantic Scholar
Evolutionary antifragile therapy is a treatment strategy to suppress drug resistance by exploiting dose response convexity
Jeffrey West, Bina Desai, Maximillian Strobl, Jill A. Gallaher +3 more
2026Cancer Research1 citations Open access
Semantic Scholar
Abstract 1924: RTK signaling and WT RAS activity as vulnerabilities in tumors with acquired resistance to GDP-state selective KRASG12C inhibitors in preclinical models
Hitendra S. Solanki, Harshit Shah, Denis Imbody, Bina Desai +10 more
2024Cancer Research1 citations
Semantic Scholar
Abstract C035: Spatially limited stroma-mediated resistance potentiates targeted therapy resistance through an integration of multiple juxtacrine and paracrine mechanisms
Bina Desai, Tatiana Miti, Sandhya Prabhakaran, D. Miroshnychenko +10 more
2024Cancer Research1 citations
Semantic Scholar
Abstract 552: Stromal facilitated multifactorial resistance to tumor cells against targeted therapies in ALK+ NSCLC
Bina Desai, Tatiana Miti, D. Miroshnychenko, Viktoriya Marusyk +7 more
2023Cancer Research1 citations
Semantic Scholar
The Pipeline for Digital Analysis of IHC Images from NSCLC Xenograft Tissues
Rachana Kandru, Bina Desai
2019bioRxiv1 citations Open access
Semantic Scholar
A reference-calibrated spatial-statistical framework for quantifying stroma-tumor cell spatial associations from histology and its geometric limits
Tatiana Miti, Daria Miroshnycenko, Bina Desai, A. Marusyk +1 more
2026bioRxiv0 citations Open access
Semantic Scholar
Abstract B026: RAF1 gene amplification drives RAS inhibitor resistance via nuclear translocation and interactions with PLK1 and Aurora A kinases
Hitendra S. Solanki, Denis Imbody, Bina Desai, A. Marusyk +1 more
2026Cancer Research0 citations
Semantic Scholar
Pharmacokinetic Acceleration via CYP3A4 Hyperactivation as a Clinically Actionable Mechanism of Targeted Therapy Resistance in NSCLC
Pragya Kumar, Menkara-Chinua N Henry, J. Pelesko, Bina Desai +12 more
2026bioRxiv0 citations
Semantic Scholar
Abstract 5512: Combining RAS(ON) G12C-selective and RAS(ON) multi-selective inhibitors overcomes sotorasib resistance driven byKRASG12C amplification or NRASG13R mutation
Hitendra S. Solanki, Denis Imbody, Bina Desai, D. Miroshnychenko +8 more
2025Cancer Research0 citations
Semantic Scholar
Evolutionary antifragile therapy
Jeffrey West, Bina Desai, M. Strobl, J. Gallaher +3 more
2025bioRxiv0 citations Open access
Semantic Scholar
Abstract A040: A novel stroma-mediated positive interaction between resistant and sensitive cells in non-small cell lung cancer facilitates drug resistance
Rishi Shah, S. Yarlagadda, M. Robertson-Tessi, Bina Desai +5 more
2024Cancer Research0 citations
Semantic Scholar
Abstract A016: Positive ecological interaction between therapy-resistant and sensitive cells, mediated by stromal niche, slows the expansion of resistant subpopulations and promotes tumor heterogeneity
Bina Desai, M. Robertson-Tessi, R. V. Velde, Tatiana Miti +6 more
2024Cancer Research0 citations
Semantic Scholar
Abstract 847: Applying the principles of convexity and concavity to guide treatment scheduling of ALK inhibitors in non-small cell lung cancer
Jeffrey West, Bina Desai, M. Strobl, Luke Pierik +4 more
2023Cancer Research0 citations
Semantic Scholar
Abstract 2858: Radiotherapy and NK cell-based immunotherapy: An evolutionary double-bind
K. Luddy, Jeffery West, M. Robertson-Tessi, Bina Desai +8 more
2023Cancer Research0 citations
Semantic Scholar
Abstract B084: Sotorasib/SHP2 inhibitors combo, KRASG12C(ON)I and RASMULTI(ON)I effectively target KRASG12C tumors developing secondary resistance to Sotorasib via KRASG12C amplification
Hitendra S. Solanki, Denis Imbody, Bina Desai, Ryoji Kato +9 more
2023Molecular Cancer Therapeutics0 citations
Semantic Scholar
Abstract B015: Wildtype RAS activity and PI3K signaling as new vulnerabilities in cells with acquired resistance to sotorasib
Denis Imbody, Hitendra S. Solanki, Bina Desai, P. Stewart +12 more
2023Molecular Cancer Research0 citations
Semantic Scholar
Abstract B012: Impact of stromal protection on in-vivo response to ALK targeted therapies in NSCLC
Bina Desai, Viktoriya Marusyk, D. Miroshnychenko, C. Gatenbee +4 more
2022Cancer Research0 citations
Semantic Scholar
Abstract 3193: Impact of stromal protection on in vivo response to ALK targeted therapies in NSCLC
Bina Desai, Viktoriya Marusyk, D. Miroshnychenko, C. Gatenbee +4 more
2022Cancer Research0 citations
Semantic Scholar
Abstract B025: Antifragile therapy
Jeffrey West, Bina Desai, M. Strobl, Luke Pierik +5 more
2022Cancer Research0 citations
Semantic Scholar
Abstract A032: Integrating spatial analysis and agent-based modeling for studies of stroma sheltering effects in NSCLC
Tatiana Miti, Anna K. Miller, D. Myroshnychenko, Bina Desai +2 more
2022Cancer Research0 citations
Semantic Scholar
Abstract PO045: Impact of fibroblast mediated stromal protection on evolution of resistance to targeted therapies in NSCLC
Bina Desai
20210 citations
Semantic Scholar
Abstract 4975: A small molecule pan Id protein antagonist shows strong antitumor activity
P. Wojnarowicz, Bina Desai, Yvette Chin, Sang Bae Lee +21 more
20170 citations
Semantic Scholar
Abstract 1649: Potent anticancer activity of an orally bioavailable small molecule, ON 013100, and its water soluble derivative, briciclib, a clinical-stage eIF4E-targeted agent
Neel Jasani, Bina Desai, Justine M. Betzu, Tanmay Dichwalkar +5 more
20150 citations
Semantic Scholar
Selective Targeting of M 3 Muscarinic Receptors : an Opportunity for Improved Treatment of Upper Gastrointestinal Carcinomas Review
Justine M. Betzu, Neel Jasani, Bina Desai, Vikas Sehdev
20140 citations
Semantic Scholar

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A. Marusyk×34
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A. Marusyk — researcher profile on SciRah
D. Miroshnychenko×18
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D. Basanta×13
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D. Basanta — researcher profile on SciRah
Viktoriya Marusyk×12
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Viktoriya Marusyk — researcher profile on SciRah

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E. Haura — researcher profile on SciRah

A. Anderson×11

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M. Robertson-Tessi×10

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M. Robertson-Tessi — researcher profile on SciRah

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Tatiana Miti×9

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Tatiana Miti — researcher profile on SciRah

Hitendra S. Solanki×8

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Hitendra S. Solanki — researcher profile on SciRah

Menkara-Chinua N Henry×8

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Menkara-Chinua N Henry — researcher profile on SciRah

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C. Gatenbee — researcher profile on SciRah