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J. Funcke · SciRah

Researcher profile · Semantic Scholar

J. Funcke

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J. Funcke — researcher profile on SciRah

h-index: 22
Works: 59
Citations: 2,128

Most-cited papers

Extracellular vesicle-Based Interorgan Transport of Mitochondria from Energetically Stressed Adipocytes
C. Crewe, J. Funcke, Shujuan Li, Nolwenn Joffin +12 more
2021Cell Metabolism410 citations Open access
Semantic Scholar
Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication
J. Funcke, P. Scherer
2019Journal of Lipid Research271 citations Open access
Semantic Scholar
Biologically inactive leptin and early-onset extreme obesity.
M. Wabitsch, J. Funcke, B. Lennerz, U. Kuhnle-Krahl +6 more
2015New England Journal of Medicine177 citations Open access
Semantic Scholar
miR-146a-mediated suppression of the inflammatory response in human adipocytes
J. Roos, Eveliina Enlund, J. Funcke, D. Tews +4 more
2015Scientific Reports110 citations Open access
Semantic Scholar
Adipocyte iron levels impinge on a fat-gut cross-talk to regulate intestinal lipid absorption and mediate protection from obesity
Zhuzhen Zhang, J. Funcke, Zhen-Zhen Zi, Shangang Zhao +17 more
2021Cell Metabolism103 citations Open access
Semantic Scholar
Severe Early-Onset Obesity Due to Bioinactive Leptin Caused by a p.N103K Mutation in the Leptin Gene
M. Wabitsch, J. Funcke, J. von Schnurbein, Friederike Denzer +12 more
2015Journal of Clinical Endocrinology and Metabolism90 citations Open access
Semantic Scholar
Monogenic forms of childhood obesity due to mutations in the leptin gene
J. Funcke, J. von Schnurbein, B. Lennerz, G. Lahr +3 more
2014Molecular and Cellular Pediatrics85 citations Open access
Semantic Scholar
Functional and Phenotypic Characteristics of Human Leptin Receptor Mutations
Adriana Nunziata, J. Funcke, G. Borck, J. von Schnurbein +6 more
2018Journal of the Endocrine Society75 citations Open access
Semantic Scholar
Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations
Nolwenn Joffin, Christy M. Gliniak, J. Funcke, V. A. Paschoal +7 more
2022Nature Metabolism70 citations
Semantic Scholar
Dysregulation of Amyloid Precursor Protein Impairs Adipose Tissue Mitochondrial Function and Promotes Obesity
Yu A. An, C. Crewe, I. W. Asterholm, K. Sun +10 more
2019Nature Metabolism63 citations Open access
Semantic Scholar
The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice
Xin-Xin Yu, Shiuhwei Chen, J. Funcke, Leon G. Straub +17 more
2024Cell Metabolism60 citations Open access
Semantic Scholar
Early childhood BMI trajectories in monogenic obesity due to leptin, leptin receptor, and melanocortin 4 receptor deficiency
K. Kohlsdorf, Adriana Nunziata, J. Funcke, S. Brandt +11 more
2018International Journal of Obesity60 citations
Semantic Scholar
The mitochondrial dicarboxylate carrier prevents hepatic lipotoxicity by inhibiting white adipocyte lipolysis
Yu A. An, Shiuhwei Chen, Ying-Feng Deng, Zhao V. Wang +8 more
2021Journal of Hepatology57 citations Open access
Semantic Scholar
Elevated UCP1 levels are sufficient to improve glucose uptake in human white adipocytes
D. Tews, T. Pula, J. Funcke, M. Jastroch +4 more
2019Redox Biology50 citations Open access
Semantic Scholar
miR-146a regulates insulin sensitivity via NPR3
J. Roos, M. Dahlhaus, J. Funcke, M. Kustermann +10 more
2020Cellular and Molecular Life Sciences38 citations Open access
Semantic Scholar
Trail (TNF-related apoptosis-inducing ligand) induces an inflammatory response in human adipocytes
Verena Zoller, J. Funcke, J. Roos, M. Dahlhaus +7 more
2017Scientific Reports33 citations Open access
Semantic Scholar
TRAIL (TNF-related apoptosis-inducing ligand) inhibits human adipocyte differentiation via caspase-mediated downregulation of adipogenic transcription factors
Verena Zoller, J. Funcke, M. Keuper, Muad Y. Abd El Hay +3 more
2016Cell Death and Disease31 citations Open access
Semantic Scholar
Hyperleptinemia contributes to antipsychotic drug-associated obesity and metabolic disorders
Shangang Zhao, Qian Lin, Wei Xiong, Li Li +24 more
2023Science Translational Medicine30 citations
Semantic Scholar
Resveratrol Suppresses PAI-1 Gene Expression in a Human In Vitro Model of Inflamed Adipose Tissue
Ivana Zagotta, E. Dimova, J. Funcke, M. Wabitsch +2 more
2013Oxidative Medicine and Cellular Longevity30 citations Open access
Semantic Scholar
The adiponectin-PPARγ axis in hepatic stellate cells regulates liver fibrosis
Shangang Zhao, Qingzhang Zhu, Wang-Hsin Lee, J. Funcke +13 more
2025Cell Reports28 citations Open access
Semantic Scholar
Rare Antagonistic Leptin Variants and Severe, Early-Onset Obesity.
J. Funcke, B. Moepps, J. Roos, J. von Schnurbein +16 more
2023New England Journal of Medicine27 citations Open access
Semantic Scholar
Measurement of immunofunctional leptin to detect and monitor patients with functional leptin deficiency
M. Wabitsch, L. Pridzun, M. Ranke, J. von Schnurbein +10 more
2016European Journal of Endocrinology27 citations Open access
Semantic Scholar
Deficient Caveolin-1 Synthesis in Adipocytes Stimulates Systemic Insulin-independent Glucose Uptake via Extracellular Vesicles.
C. Crewe, Shiuhwei Chen, Da-Wei Bu, Christy M. Gliniak +10 more
2022Diabetes22 citations Open access
Semantic Scholar
Defining lipedema's molecular hallmarks by multi-omics approach for disease prediction in women.
Leon G. Straub, J. Funcke, Nolwenn Joffin, Chanmin Joung +9 more
2025Metabolism: Clinical and Experimental21 citations Open access
Semantic Scholar
Classification of Congenital Leptin Deficiency
J. von Schnurbein, Stefanie Zorn, Adriana Nunziata, S. Brandt +6 more
2024Journal of Clinical Endocrinology and Metabolism21 citations Open access
Semantic Scholar
TNF‐related apoptosis‐inducing ligand promotes human preadipocyte proliferation via ERK1/2 activation
J. Funcke, Verena Zoller, Muad Y. Abd El Hay, K. Debatin +2 more
2015The FASEB Journal21 citations Open access
Semantic Scholar
PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels
Qingzhang Zhu, Shiuhwei Chen, J. Funcke, Leon G. Straub +14 more
2024Nature Metabolism20 citations Open access
Semantic Scholar
Estimated prevalence of potentially damaging variants in the leptin gene
Adriana Nunziata, G. Borck, J. Funcke, K. Kohlsdorf +7 more
2017Molecular and Cellular Pediatrics20 citations Open access
Semantic Scholar
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex
Chao Li, Xuenan Sun, J. Funcke, Lauri Vanharanta +34 more
2025Science14 citations Open access
Semantic Scholar
Age- and BMI-Associated Expression of Angiogenic Factors in White Adipose Tissue of Children
Niklas Gaebler, B. Haggenmüller, Melanie Kapapa, A. Serra +9 more
2019International Journal of Molecular Sciences11 citations Open access
Semantic Scholar
Activating Connexin43 gap junctions primes adipose tissue for therapeutic intervention
Yi Zhu, Na Li, Mingyang Huang, Xiangshan Chen +14 more
2022Acta Pharmaceutica Sinica B10 citations Open access
Semantic Scholar
Leptin as a key driver for organ fibrogenesis
Xuenan Sun, Shiuhwei Chen, Shan-Gang Zhao, J. Funcke +18 more
2025Science Advances8 citations
Semantic Scholar
Neuronal GPR75 deficiency protects against diet-induced obesity in a humanized mouse model
Xuenan Sun, J. Funcke, Chanmin Joung, Chao Li +10 more
2026Science Advances7 citations Open access
Semantic Scholar
Inhibiting inflammation in adipocytes accelerates mammary tumor development in mice
Dae-Seok Kim, Toshiharu Onodera, J. Funcke, Kyounghee Min +11 more
2025Journal of Clinical Investigation6 citations Open access
Semantic Scholar
CD90 Is Dispensable for White and Beige/Brown Adipocyte Differentiation
M. Dahlhaus, J. Roos, D. Engel, D. Tews +12 more
2020International Journal of Molecular Sciences6 citations Open access
Semantic Scholar
Adipogenin Dictates Adipose Tissue Expansion by Facilitating the Assembly of a Dodecameric Seipin Complex
Chao Li, Xuenan Sun, J. Funcke, Lauri Vanharanta +28 more
2024bioRxiv5 citations
Semantic Scholar
Lipedema: a chronic adipose tissue disease.
J. Funcke, Philipp E. Scherer, Leon G. Straub
2025Trends in Molecular Medicine4 citations
Semantic Scholar
Biologically inactive leptin and early-onset extreme obesity.
P. Fischer-Posovszky, J. Funcke, M. Wabitsch
2015New England Journal of Medicine4 citations
Semantic Scholar
VCAM-1/Ezrin axis antagonizes myocardial damage in ischemia-reperfusion injury.
A. Ferdous, Ariel Diaz, Daniel Daou, Diana Dad Zada +13 more
2025Cell Death and Differentiation2 citations Open access
Semantic Scholar
ETP-specific-knockout mice reveal endotrophin as a key regulator of kidney fibrosis in ischemia–reperfusion injury models
Dae-Seok Kim, J. Funcke, Shiuhwei Chen, Kyounghee Min +10 more
2025Experimental and Molecular Medicine2 citations Open access
Semantic Scholar
Hyaluronidase-1 mediates postprandial suppression of hepatic gluconeogenesis
Xi Chen, S. Dogné, Yanru Deng, Huiqiao Li +18 more
2025Life Metabolism2 citations Open access
Semantic Scholar
Fettgewebe als endokrines Organ
P. Fischer-Posovszky, J. Funcke
2019Pädiatrische Endokrinologie und Diabetologie2 citations
Semantic Scholar
ETP-Specific Knockout Mice Reveal Endotrophin as a Key Regulator of Kidney Fibrosis in Ischemia-Reperfusion Injury Models
Dae-Seok Kim, J. Funcke, Shiuhwei Chen, Kyounghee Min +6 more
2025bioRxiv1 citations Open access
Semantic Scholar
Much ado about NAA-thing
J. Funcke, P. Scherer
2025Nature Metabolism1 citations
Semantic Scholar
Frühkindlicher BMI-Verlauf bei monogener Adipositas
K. Kohlsdorf, A. Nunziata, J. Funcke, S. Brandt +9 more
2017Medizinische Genetik1 citations Open access
Semantic Scholar
[Developments in and results of coronary angioplasty (PTCA) in the years 1981-1989 exemplified by 2015 treatments].
H. Figulla, J. Funcke, V. Wiegand, C. Ehlers +1 more
1991Medizinische Klinik1 citations
Semantic Scholar
Adipocytes signal to recruit specific mRNAs from surrounding cells to restore expression deficits
C. Crewe, Christy M. Gliniak, Toshiharu Onodera, Shiuhwei Chen +14 more
2026Nature Communications0 citations Open access
Semantic Scholar
Abstract Mon004: VCAM-1/Ezrin Axis Antagonizes Myocardial Damage in Ischemia-Reperfusion Injury
Daniel Daou, A. Ferdous, Ariel Diaz Montecinos, Diana Dad Zada +13 more
2026Circulation Research0 citations
Semantic Scholar
Non-enzymatic ABHD6 interacts with Akt-FoxO1 axis to regulate selective hepatic insulin resistance
Guannan Li, Laurence T. Maeyens, Jiyuan Yin, J. Funcke +18 more
2026bioRxiv0 citations Open access
Semantic Scholar
Non-enzymatic hepatic ABHD6 interacts with Akt-FoxO1 axis to regulate metabolic health
Guannan Li, Laurence T. Maeyens, Jiyuan Yin, J. Funcke +18 more
2026Nature Communications0 citations Open access
Semantic Scholar

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M. Wabitsch×20
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M. Wabitsch — researcher profile on SciRah
P. Fischer-Posovszky×19
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P. Fischer-Posovszky — researcher profile on SciRah
Shiuhwei Chen×15
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Shiuhwei Chen — researcher profile on SciRah
K. Debatin×13
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K. Debatin — researcher profile on SciRah

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Chanmin Joung — researcher profile on SciRah

Leon G. Straub×10

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Leon G. Straub — researcher profile on SciRah

Ruth Gordillo×9

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C. Kusminski×9

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Philipp E. Scherer×9

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Yi Zhu — researcher profile on SciRah

J. von Schnurbein×8

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J. von Schnurbein — researcher profile on SciRah