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Outi Haapanen · SciRah

Researcher profile · Semantic Scholar

Outi Haapanen

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Outi Haapanen — researcher profile on SciRah

h-index: 13
Works: 38
Citations: 809

Most-cited papers

High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease
K. Parey, Outi Haapanen, Vivek Sharma, H. Köfeler +8 more
2019Science Advances132 citations Open access
Semantic Scholar
Structural basis of mitochondrial membrane bending by the I–II–III2–IV2 supercomplex
A. Mühleip, R. K. Flygaard, R. Baradaran, Outi Haapanen +5 more
2023Nature120 citations Open access
Semantic Scholar
High-resolution structure and dynamics of mitochondrial complex I—Insights into the proton pumping mechanism
K. Parey, Jonathan Lasham, D. Mills, Amina Djurabekova +7 more
2021bioRxiv107 citations Open access
Semantic Scholar
Redox-coupled quinone dynamics in the respiratory complex I
Judith Warnau, Vivek Sharma, A. P. Gamiz-Hernandez, A. Di Luca +5 more
2018Proceedings of the National Academy of Sciences of the United States of America95 citations Open access
Semantic Scholar
Role of water and protein dynamics in proton pumping by respiratory complex I
Outi Haapanen, Vivek Sharma
2017Scientific Reports58 citations Open access
Semantic Scholar
Role of Second Quinone Binding Site in Proton Pumping by Respiratory Complex I
Outi Haapanen, Amina Djurabekova, Vivek Sharma
2019Frontiers in Chemistry50 citations Open access
Semantic Scholar
Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I
Etienne Galemou Yoga, K. Parey, Amina Djurabekova, Outi Haapanen +5 more
2020Nature Communications44 citations Open access
Semantic Scholar
Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics.
E. G. Yoga, Outi Haapanen, I. Wittig, K. Siegmund +2 more
2019Biochimica et Biophysica Acta - Bioenergetics37 citations Open access
Semantic Scholar
A modeling and simulation perspective on the mechanism and function of respiratory complex I.
Outi Haapanen, Vivek Sharma
2018Biochimica et Biophysica Acta - Bioenergetics32 citations Open access
Semantic Scholar
Coupling of quinone dynamics to proton pumping in respiratory complex I.
Outi Haapanen, M. Reidelbach, Vivek Sharma
2020Biochimica et Biophysica Acta - Bioenergetics26 citations Open access
Semantic Scholar
Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations
Yong-Chan Lee, Outi Haapanen, Anton Altmeyer, W. Kühlbrandt +2 more
2022bioRxiv25 citations Open access
Semantic Scholar
Oversized ubiquinones as molecular probes for structural dynamics of the ubiquinone reaction site in mitochondrial respiratory complex I
Shinpei Uno, Takahiro Masuya, K. Shinzawa-Itoh, Jonathan Lasham +6 more
2020Journal of Biological Chemistry21 citations Open access
Semantic Scholar
Proton motive function of the terminal antiporter-like subunit in respiratory complex I.
Amina Djurabekova, Outi Haapanen, Vivek Sharma
2020Biochimica et Biophysica Acta - Bioenergetics18 citations Open access
Semantic Scholar
Redox- and protonation-state driven substrate-protein dynamics in respiratory complex I
Outi Haapanen, Vivek Sharma
202114 citations Open access
Semantic Scholar
Docking and molecular simulations reveal a quinone‐binding site on the surface of respiratory complex I
Amina Djurabekova, Etienne Galemou Yoga, Aino Nyman, Antti Pirttikoski +3 more
2022FEBS Letters10 citations Open access
Semantic Scholar
Tunnel dynamics of quinone derivatives and its coupling to protein conformational rearrangements in respiratory complex I
Jonathan Lasham, Outi Haapanen, V. Zickermann, Vivek Sharma
2022bioRxiv8 citations Open access
Semantic Scholar
Atomistic Molecular Dynamics Simulations of Mitochondrial DNA Polymerase γ: Novel Mechanisms of Function and Pathogenesis.
L. Euro, Outi Haapanen, T. Róg, I. Vattulainen +2 more
2017Biochemistry4 citations
Semantic Scholar
Unexpected structures formed by the kinase RET C634R mutant extracellular domain suggest potential oncogenic mechanisms in MEN2A
Yixin Liu, Orquidea De Castro Ribeiro, Outi Haapanen, G. Craven +3 more
2022Journal of Biological Chemistry3 citations Open access
Semantic Scholar
Conformational dynamics of a histidine molecular switch in a cation/proton antiporter.
Cristina Pecorilla, Anton Altmeyer, Outi Haapanen, Yongchan Lee +2 more
2025Biochimica et Biophysica Acta - Bioenergetics2 citations Open access
Semantic Scholar
Conformational dynamics of a histidine molecular switch in a cation/proton antiporter
Cristina Pecorilla, Anton Altmeyer, Outi Haapanen, Yongchan Lee +2 more
2024bioRxiv2 citations Open access
Semantic Scholar
Structural basis of mitochondrial membrane bending by I-II-III2-IV2 supercomplex
A. Mühleip, R. K. Flygaard, Outi Haapanen, R. Baradaran +5 more
2022bioRxiv2 citations Open access
Semantic Scholar
Atomistic Molecular Dynamics Simulations of Mitochondrial DNA Polymerase gamma Euro , Liliya 2017-03-07
Outi Haapanen, T. Róg, I. Vattulainen, A. Suomalainen +1 more
2 citations
Semantic Scholar
Role of Protein Hydration and Dynamics in Proton Pumping by Respiratory Complex I
Outi Haapanen, Vivek Sharma
20171 citations
Semantic Scholar
Proton translocation channels in respiratory complex I probed by molecular dynamics simulations
Outi Haapanen
20171 citations
Semantic Scholar
Structural Rewiring of IL-7R Dimerization by an Oncogenic Transmembrane Mutation Can Be Reversed by Rational Design
Qian Wang, Min Chen, Asma Lasram, Saana Vihuri +10 more
2026bioRxiv0 citations
Semantic Scholar
Mutagenesis in the Mrp antiporter from Bacillus pseudofirmus identifies residues critical for the histidine switch mechanism
Anton Altmeyer, Cristina Pecorilla, Outi Haapanen, Yongchan Lee +2 more
2024Biochimica et Biophysica Acta0 citations Open access
Semantic Scholar
From respiratory supercomplexes to megacomplexes
Outi Haapanen
2024Annales Academiae Scientiarum Fennicae0 citations Open access
Semantic Scholar
Molecular dynamics simulations of a histidine switch in Mrp antiporter complex
Cristina Pecorilla, Anton Altmeyer, Outi Haapanen, Yongchan Lee +2 more
2024Biochimica et Biophysica Acta0 citations Open access
Semantic Scholar
Molecular dynamics simulations reveal the coupling of quinone dynamics to protein conformational changes in respiratory complex I
Jonathan Lasham, Outi Haapanen, V. Zickermann, Vivek Sharma
2022Biochimica et Biophysica Acta0 citations Open access
Semantic Scholar
Mechanistic insights on sodium and proton transfer pathways from molecular dynamics simulations of Mrp-type antiporter
Outi Haapanen, Yong-Chan Lee, Anton Altmeyer, W. Kühlbrandt +2 more
2022Biochimica et Biophysica Acta0 citations Open access
Semantic Scholar
Targeting respiratory complex I—molecular mechanism and drug design
Vivek Sharma, Jonathan Lasham, Outi Haapanen
20210 citations
Semantic Scholar
After all, how many catalytically active quinone molecules are bound to the respiratory complex I?
Outi Haapanen, K. Parey, E. G. Yoga, V. Zickermann +1 more
20190 citations
Semantic Scholar
The high-resolution cryo-EM structure of respiratory complex I from the aerobic yeast Yarrowia lipolytica
V. Zickermann, K. Parey, Outi Haapanen, Vivek Sharma +3 more
20190 citations
Semantic Scholar
Proton transfer pathways in the antiporter-like subunits of complex I revealed by multiscale simulations
Amina Djurabekova, Outi Haapanen, Vivek Sharma
20190 citations
Semantic Scholar
A highly conserved loop in the PSST subunit of complex I is essential for ubiquinone binding and reduction
E. G. Yoga, Outi Haapanen, Vivek Sharma, V. Zickermann
2018Biochimica et Biophysica Acta0 citations Open access
Semantic Scholar
Quinone Dynamics Coupled to Proton Pumping in Bacterial and Mammalian Respiratory Complex I
Outi Haapanen, Amina Djurabekova, Vivek Sharma
20180 citations
Semantic Scholar
Large scale atomistic simulations unveil key role of ubiquinone dynamics in proton pumping by mitochondrial complex I
Vivek Sharma, Outi Haapanen
2018Biochimica et Biophysica Acta0 citations Open access
Semantic Scholar
Computational investigation of the redox-coupled proton pumping in respiratory complex I
Vivek Sharma, Judith Warnau, A. P. Gamiz-Hernandez, Outi Haapanen +5 more
20160 citations Open access
Semantic Scholar

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