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S. Gehen · SciRah

Researcher profile · Semantic Scholar

S. Gehen

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S. Gehen — researcher profile on SciRah

h-index: 15
Works: 39
Citations: 880

Most-cited papers

Pharmaceutical toxicology: designing studies to reduce animal use, while maximizing human translation.
Kathryn L Chapman, H. Holzgrefe, L. Black, Marilyn J. Brown +11 more
2013Regulatory toxicology and pharmacology : RTP127 citations Open access
Semantic Scholar
Acute toxicity testing of chemicals—Opportunities to avoid redundant testing and use alternative approaches
S. Creton, I. Dewhurst, L. Earl, S. Gehen +5 more
2010Critical Reviews in Toxicology95 citations
Semantic Scholar
Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report
A. Clippinger, D. Allen, A. Jarabek, Marco Corvaro +15 more
2017Toxicology in Vitro90 citations Open access
Semantic Scholar
Pathway-Based Predictive Approaches for Non-Animal Assessment of Acute Inhalation Hazard Determination
A. Clippinger, D. Allen, H. Behrsing, K. BéruBé +31 more
2018Toxicology in Vitro85 citations Open access
Semantic Scholar
Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing
J. Hamm, Kristie Sullivan, A. Clippinger, J. Strickland +20 more
2017Toxicology in Vitro65 citations Open access
Semantic Scholar
hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress
S. Gehen, R. Staversky, R. Bambara, P. Keng +1 more
2008Oncogene57 citations Open access
Semantic Scholar
Downregulation of PCNA potentiates p21-mediated growth inhibition in response to hyperoxia.
S. Gehen, P. Vitiello, R. Bambara, P. Keng +1 more
2007American Journal of Physiology - Lung cellular and Molecular Physiology44 citations
Semantic Scholar
Chlorpyrifos: weight of evidence evaluation of potential interaction with the estrogen, androgen, or thyroid pathways.
Daland R. Juberg, S. Gehen, K. Coady, M. J. LeBaron +3 more
2013Regulatory toxicology and pharmacology : RTP41 citations Open access
Semantic Scholar
Application of the KeratinoSens™ assay for assessing the skin sensitization potential of agrochemical active ingredients and formulations.
R. Settivari, S. Gehen, Ricardo Acosta Amado, Nicolo R. Visconti +2 more
2015Regulatory toxicology and pharmacology : RTP34 citations
Semantic Scholar
A retrospective analysis of in vivo eye irritation, skin irritation and skin sensitisation studies with agrochemical formulations: Setting the scene for development of alternative strategies
M. Corvaro, S. Gehen, K. Andrews, R. Chatfield +2 more
2017Regulatory toxicology and pharmacology : RTP24 citations
Semantic Scholar
Challenges and Opportunities in the Global Regulation of Crop Protection Products
S. Gehen, Marco Corvaro, Jennifer M. Jones, Mingming Ma +1 more
2019Organic Process Research & Development23 citations
Semantic Scholar
Application of Defined Approaches for Skin Sensitization to Agrochemical Products
J. Strickland, J. Truax, M. Corvaro, R. Settivari +8 more
2022Frontiers in Toxicology22 citations Open access
Semantic Scholar
GHS additivity formula: A true replacement method for acute systemic toxicity testing of agrochemical formulations.
M. Corvaro, S. Gehen, K. Andrews, R. Chatfield +2 more
2016Regulatory toxicology and pharmacology : RTP21 citations
Semantic Scholar
Review of the pharmacokinetics and metabolism of triclopyr herbicide in mammals: Impact on safety assessments.
M. Bartels, C. Brown, Git W. Chung, M. Chan +3 more
2020Regulatory toxicology and pharmacology : RTP19 citations
Semantic Scholar
Cell Injury , Repair , Aging and Apoptosis p 21 Cip 1 Protection against Hyperoxia Requires Bcl-XL and Is Uncoupled from Its Ability to Suppress Growth
P. Vitiello, R. Staversky, S. Gehen, C. Johnston +3 more
201015 citations
Semantic Scholar
p21Cip1/Waf1/Sdi1 protects against hyperoxia by maintaining expression of Bcl-XL
R. Staversky, P. Vitiello, S. Gehen, C. Helt +3 more
200615 citations
Semantic Scholar
Tiered application of the neutral red release and EpiOcular™ assays for evaluating the eye irritation potential of agrochemical formulations.
R. Settivari, Ricardo Acosta Amado, M. Corvaro, Nicolo R. Visconti +4 more
2016Regulatory toxicology and pharmacology : RTP14 citations
Semantic Scholar
Retrospective evaluation of the impact of functional immunotoxicity testing on pesticide hazard identification and risk assessment
S. Gehen, A. Blacker, D. Boverhof, T. Hanley +4 more
2014Critical Reviews in Toxicology11 citations
Semantic Scholar
p21(Cip1/Waf1/Sdi1) protects against hyperoxia by maintaining expression of Bcl-X(L).
R. Staversky, P. Vitiello, S. Gehen, C. Helt +3 more
2006Free Radical Biology & Medicine11 citations
Semantic Scholar
Loss of Gadd45a does not modify the pulmonary response to oxidative stress.
J. Roper, S. Gehen, R. Staversky, M. Hollander +2 more
2005American Journal of Physiology - Lung cellular and Molecular Physiology10 citations
Semantic Scholar
Weight of evidence analysis of the tumorigenic potential of 1,3-dichloropropene supports a threshold-based risk assessment
Z. Yan, M. Bartels, B. Gollapudi, J. Driver +6 more
2020Critical Reviews in Toxicology9 citations Open access
Semantic Scholar
Toxicology of Triazolopyrimidine Herbicides
R. Billington, S. Gehen, T. Hanley
20108 citations
Semantic Scholar
GARD™skin and GARD™potency: A proof-of-concept study investigating applicability domain for agrochemical formulations.
M. Corvaro, Joseph Henriquez, Raja Settivari, U. Mattson +4 more
2024Regulatory toxicology and pharmacology : RTP7 citations
Semantic Scholar
Evaluation of potential human health effects associated with the agricultural uses of 1,3-D: Spatial and temporal stochastic risk analysis.
J. Driver, P. Price, I. vanWesenbeeck, J. Ross +6 more
2016Science of the Total Environment6 citations
Semantic Scholar
Developmental toxicity studies on triclopyr acid, triclopyr butoxyethyl ester and triclopyr triethylamine salt in the rabbit.
S. M. Barlow, C. Terry, S. Gehen, Marco Corvaro
2022Food and Chemical Toxicology5 citations Open access
Semantic Scholar
Letter to the editor regarding Heringa et al. (2020) paper entitled "use of the Kinetically-derived Maximum Dose concept in selection of top doses for toxicity studies hampers proper hazard assessment and risk management".
C. Terry, J. Domoradzki, Carrie R. Fleming, S. Gehen +3 more
2020Regulatory toxicology and pharmacology : RTP5 citations
Semantic Scholar
In vivo mutagenicity evaluation of the soil fumigant 1,3-dichloropropene.
Melissa A. Badding, B. Gollapudi, S. Gehen, Z. Yan
2020Mutagenesis5 citations
Semantic Scholar
p21Cip1/WAF1/Sdi1 Does Not Affect Expression of Base Excision DNA Repair Enzymes During Chronic Oxidative Stress
M. O'Reilly, P. Vitiello, S. Gehen, R. Staversky
2005Antioxidants and Redox Signaling5 citations
Semantic Scholar
Reproductive and developmental evaluations of triclopyr acid, triclopyr butoxyethyl ester and triclopyr triethylamine salt in the rat.
S. Barlow, C. Terry, S. Gehen, Marco Corvaro
2022Food and Chemical Toxicology4 citations Open access
Semantic Scholar
Mechanism of 1,3-dichloropropene-induced rat liver carcinogenesis.
J. Klaunig, S. Gehen, Ze-Min Wang, P. Klein +1 more
2015Toxicological Sciences3 citations
Semantic Scholar
A retrospective study on EU harmonised classifications for carcinogenicity to guide future research.
C. Terry, Z. Yan, Marco Corvaro, S. Gehen
2020Regulatory toxicology and pharmacology : RTP2 citations
Semantic Scholar
Current status of alternative methods for assessing immunotoxicity: A chemical industry perspective
R. Settivari, Shannon Krieger, Stuart Hindle, S. Gehen +2 more
20172 citations
Semantic Scholar
An Approach to Setting Vertebrate Animal-use Benchmarks for Agrochemical and GM Crop Testing to Facilitate Future Animal Reduction Efforts
Joseph Henriquez, M. Merrell, Carey A. Mathesius, Raja Settivari +5 more
2025Alternatives to laboratory animals : ATLA1 citations
Semantic Scholar
Modelling Pesticide Degradation in Soil: Influence of Chemical and Soil Properties on DT50 Prediction.
Chong-Meng Xu, F. Worrall, M. Burns, Andrew Eatherall +1 more
2026Environmental Toxicology and Chemistry0 citations
Semantic Scholar
Integrating Systemic Toxicity and Toxicokinetic Data to Inform the Need for Subchronic Dog Studies in Human Health Safety Assessments of Agrochemicals.
L. Murphy, R. Mingoia, Enrica Bianchi, V. Lukacova +8 more
2026Regulatory toxicology and pharmacology : RTP0 citations Open access
Semantic Scholar
P10-21 Spinosad – mode of action and human relevance assessment of dystocia in rats
M. Corvaro, K. Johnson, M. Himmelstein, E. Bianchi +10 more
2024Toxicology Letters0 citations
Semantic Scholar
P06-13 Spinosad – mode of action and human relevance assessment of dystocia in rats
M. Corvaro, K. Johnson, M. Himmelstein, E. Bianchi +7 more
2022Toxicology Letters0 citations
Semantic Scholar
Re-shaping acute toxicity testing of agrochemical formulations by combining the GHS ATE formula and in vitro approaches
M. Corvaro, S. Gehen, K. Andrews, R. Chatfield +4 more
20150 citations
Semantic Scholar
Bcl-X L and Is Uncoupled from Its Ability to Suppress Growth
P. Vitiello, R. Staversky, S. Gehen, C. Johnston +3 more
20060 citations
Semantic Scholar

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