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R. Lorence · SciRah

Researcher profile · Semantic Scholar

R. Lorence

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R. Lorence — researcher profile on SciRah

h-index: 28
Works: 83
Citations: 4,663

Most-cited papers

Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial.
V. Miller, V. Hirsh, J. Cadranel, Yuh-Min Chen +14 more
2012The Lancet Oncology976 citations
Semantic Scholar
Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial.
J. Yang, J. Shih, W. Su, T. Hsia +12 more
2012The Lancet Oncology421 citations Open access
Semantic Scholar
Phase I trial of intravenous administration of PV701, an oncolytic virus, in patients with advanced solid cancers.
A. Pecora, N. Rizvi, G. Cohen, N. Meropol +10 more
2002Journal of Clinical Oncology419 citations
Semantic Scholar
Newcastle disease virus selectively kills human tumor cells.
K. Reichard, R. Lorence, Christopher J. Cascino, M. Peeples +4 more
1992Journal of Surgical Research251 citations
Semantic Scholar
LUX-Lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations.
James Chih-Hsin Yang, M. Schuler, N. Yamamoto, K. O'Byrne +16 more
2012Journal of Clinical Oncology205 citations
Semantic Scholar
Newcastle disease virus therapy of human tumor xenografts: antitumor effects of local or systemic administration.
A. Phuangsab, R. Lorence, Kirk W. Reichard, M. Peeples +1 more
2001Cancer Letters173 citations
Semantic Scholar
Complete regression of human fibrosarcoma xenografts after local Newcastle disease virus therapy.
R. Lorence, B. Katubig, Kirk W. Reichard, H. M. Reyes +4 more
1994Cancer Research161 citations
Semantic Scholar
Newcastle disease virus as an antineoplastic agent: induction of tumor necrosis factor-alpha and augmentation of its cytotoxicity.
R. Lorence, P. A. Rood, K. Kelley
1988Journal of the National Cancer Institute154 citations
Semantic Scholar
The pituitary gland is required for protection against lethal effects of Salmonella typhimurium.
C. Edwards, L. M. Yunger, R. Lorence, R. Dantzer +1 more
1991Proceedings of the National Academy of Sciences of the United States of America130 citations Open access
Semantic Scholar
Complete regression of human neuroblastoma xenografts in athymic mice after local Newcastle disease virus therapy.
R. Lorence, K. Reichard, B. Katubig, H. M. Reyes +5 more
1994Journal of the National Cancer Institute127 citations
Semantic Scholar
A Phase 1 Clinical Study of Intravenous Administration of PV701, an Oncolytic Virus, Using Two-Step Desensitization
S. Laurie, J. Bell, H. Atkins, J. Roach +5 more
2006Clinical Cancer Research124 citations
Semantic Scholar
An Optimized Clinical Regimen for the Oncolytic Virus PV701
S. Hotte, R. Lorence, H. Hirte, S. Polawski +5 more
2007Clinical Cancer Research114 citations
Semantic Scholar
Phase 1 clinical experience using intravenous administration of PV701, an oncolytic Newcastle disease virus.
R. Lorence, M. Roberts, J. O'Neil, W. Groene +3 more
2007Current Cancer Drug Targets113 citations
Semantic Scholar
Overview of phase I studies of intravenous administration of PV701, an oncolytic virus.
R. Lorence, A. Pecora, P. Major, S. Hotte +4 more
2003Current opinion in molecular therapeutics (Print)112 citations
Semantic Scholar
In vivo administration of recombinant growth hormone or gamma interferon activities macrophages: enhanced resistance to experimental Salmonella typhimurium infection is correlated with generation of reactive oxygen intermediates
C. Edwards, S. M. Ghiasuddin, L. Yunger, R. Lorence +3 more
1992Infection and Immunity105 citations Open access
Semantic Scholar
Hypophysectomy Inhibits the Synthesis of Tumor Necrosis Factor α by Rat Macrophages: Partial Restoration by Exogenous Growth Hormone or Interferon γ
C. Edwards, R. Lorence, D. M. Dunham, S. Arkins +5 more
199193 citations
Semantic Scholar
Coulometric and spectroscopic analysis of the purified cytochrome d complex of Escherichia coli: evidence for the identification of "cytochrome a1" as cytochrome b595.
R. Lorence, J. Koland, R. Gennis
1986Biochemistry89 citations
Semantic Scholar
Activity of Afatinib in Heavily Pretreated Patients With ERBB2 Mutation–Positive Advanced NSCLC: Findings From a Global Named Patient Use Program
S. Peters, A. Curioni-Fontecedro, H. Nechushtan, J. Shih +9 more
2018Journal of Thoracic Oncology86 citations Open access
Semantic Scholar
Symptom and Quality of Life Benefit of Afatinib in Advanced Non–Small-Cell Lung Cancer Patients Previously Treated with Erlotinib or Gefitinib: Results of a Randomized Phase IIb/III Trial (LUX-Lung 1)
V. Hirsh, J. Cadranel, X. Cong, D. Fairclough +5 more
2013Journal of Thoracic Oncology78 citations Open access
Semantic Scholar
Properties of a copper-containing cytochrome c1aa3 complex: a terminal oxidase of the extreme thermophile Thermus thermophilus HB8.
James A. Fee, Miles G. Choc, Karen L. Findling, R. Lorence +1 more
1980Proceedings of the National Academy of Sciences of the United States of America76 citations Open access
Semantic Scholar
Naturally oncolytic viruses.
M. Roberts, R. Lorence, W. Groene, M. Bamat
2006Current opinion in molecular therapeutics (Print)61 citations
Semantic Scholar
Respiratory proteins from the extremely thermophilic aerobic bacterium, Thermus thermophilus. Purification procedures for cytochromes c552, c555,549, and c1aa3 and chemical evidence for a single subunit cytochrome aa3.
Tatsuro Yoshida, R. Lorence, Miles G. Choc, G. Tarr +2 more
1984Journal of Biological Chemistry54 citations Open access
Semantic Scholar
Identification of subunit I as the cytochrome b558 component of the cytochrome d terminal oxidase complex of Escherichia coli.
G. N. Green, R. G. Kranz, R. Lorence, R. Gennis
1984Journal of Biological Chemistry54 citations Open access
Semantic Scholar
Isolation and characterization of an Escherichia coli mutant lacking the cytochrome o terminal oxidase
Douglas C. Au, R. Lorence, R. Gennis
1985Journal of Bacteriology46 citations Open access
Semantic Scholar
Effects of pH and detergent on the kinetic and electrochemical properties of the purified cytochrome d terminal oxidase complex of Escherichia coli.
R. Lorence, Michael J. Miller, A. Borochov, Rosalind Faiman-Weinberg +1 more
1984Biochimica et Biophysica Acta35 citations
Semantic Scholar
Spectroscopic and quantitative analysis of the oxygenated and peroxy states of the purified cytochrome d complex of Escherichia coli.
R. Lorence, R. Gennis
1989Journal of Biological Chemistry33 citations Open access
Semantic Scholar
Replication-Competent, Oncolytic Newcastle Disease Virus for Cancer Therapy
R. Lorence, Roberts Ms, W. Groene, H. Rabin
200131 citations
Semantic Scholar
Trypsin proteolysis of the cytochrome d complex of Escherichia coli selectively inhibits ubiquinol oxidase activity while not affecting N,N,N',N'-tetramethyl-p-phenylenediamine oxidase activity.
R. Lorence, K. Carter, R. Gennis, K. Matsushita +1 more
1988Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Cardiac safety of afatinib: a review of data from clinical trials
M. Ewer, K. Patel, D. O’Brien, R. Lorence
2015Cardio-Oncology28 citations Open access
Semantic Scholar
Specific overproduction and purification of the cytochrome b558 component of the cytochrome d complex from Escherichia coli.
G. N. Green, R. Lorence, R. Gennis
1986Biochemistry28 citations
Semantic Scholar
Potentiometric analysis of the cytochromes of an Escherichia coli mutant strain lacking the cytochrome d terminal oxidase complex
R. Lorence, G. N. Green, R. Gennis
1984Journal of Bacteriology27 citations Open access
Semantic Scholar
A phase II trial of afatinib (BIBW 2992) in patients (pts) with advanced non-small cell lung cancer previously treated with erlotinib (E) or gefitinib (G).
N. Yamamoto, N. Katakami, S. Atagi, T. Hida +16 more
2011Journal of Clinical Oncology26 citations
Semantic Scholar
Hypophysectomy inhibits the synthesis of tumor necrosis factor alpha by rat macrophages: partial restoration by exogenous growth hormone or interferon gamma.
C. Edwards, R. Lorence, D. M. Dunham, S. Arkins +5 more
1991Endocrinology25 citations
Semantic Scholar
Use of an azido-ubiquinone derivative to identify subunit I as the ubiquinol binding site of the cytochrome d terminal oxidase complex of Escherichia coli.
Fu-De Yang, Linda P. C. Yu, Chang-An Yu, R. Lorence +1 more
1986Journal of Biological Chemistry22 citations Open access
Semantic Scholar
Retinoic acid enhances killing of neuroblastoma cells by Newcastle disease virus.
Kirk W. Reichard, R. Lorence, Burt B. Katubig, M. Peeples +1 more
1993Journal of Pediatric Surgery17 citations
Semantic Scholar
Global named patient use program of afatinib in advanced non-small-cell lung carcinoma patients who progressed following prior therapies.
F. Cappuzzo, R. Soo, M. Hochmair, M. Schuler +9 more
2018Future Oncology16 citations Open access
Semantic Scholar
REPORTS Serum Protease Inhibitor Abrogation of Newcastle Disease Virus Enhancement of Cytolysis by Recombinant Tumor Necrosis Factors Alpha and Beta
P. A. Rood, R. Lorence, K. Kelley
199013 citations
Semantic Scholar
Phase II trial of afatinib in patients with advanced urothelial carcinoma with genetic alterations in ERBB1-3 (LUX-Bladder 1)
A. Font, B. Mellado, M. Climent, J. Virizuela +17 more
2023British Journal of Cancer12 citations Open access
Semantic Scholar
In vivo effects of recombinant interferon-γ: augmentation of endotoxin-induced necrosis of tumors and priming of macrophages for tumor necrosis factor-α production
R. Lorence, C. Edwards, R. Walter, K. Kelley +1 more
199012 citations
Semantic Scholar
Cytochrome b558 monitors the steady state redox state of the ubiquinone pool in the aerobic respiratory chain of Escherichia coli.
R. Lorence, K. Carter, G. N. Green, R. Gennis
1987Journal of Biological Chemistry12 citations Open access
Semantic Scholar
Naturally occurring viruses for the treatment of cancer.
Michael S. Roberts, W. Groene, R. Lorence, M. Bamat
2006Discover medicine10 citations
Semantic Scholar
Afatinib in paediatric patients with recurrent/refractory ErbB-dysregulated tumours: Results of a phase I/expansion trial.
B. Geoerger, L. Marshall, K. Nysom, G. Makin +11 more
2023European Journal of Cancer7 citations Open access
Semantic Scholar
Serum protease inhibitor abrogation of Newcastle disease virus enhancement of cytolysis by recombinant tumor necrosis factors alpha and beta.
P. A. Rood, R. Lorence, K. Kelley
1990Journal of the National Cancer Institute7 citations
Semantic Scholar
Observations on the c-type cytochromes of the extreme thermophile, Thermus thermophilus HB8: cytochrome c552 is located in the periplasmic space.
R. Lorence, Tatsuro Yoshida, K. Findling, James A. Fee
1981Biochemical and Biophysical Research Communications - BBRC7 citations Open access
Semantic Scholar
Phase II study of afatinib plus pembrolizumab in patients with squamous cell carcinoma of the lung following progression during or after first-line chemotherapy (LUX-Lung-IO).
B. Levy, F. Barlesi, L. Paz-Ares, J. Bennouna +14 more
2022Lung Cancer6 citations Open access
Semantic Scholar
In vivo effects of recombinant interferon-gamma: augmentation of endotoxin-induced necrosis of tumors and priming of macrophages for tumor necrosis factor-alpha production.
R. Lorence, C. Edwards, R. Walter, K. Kelley +1 more
1990Cancer Letters5 citations
Semantic Scholar
Phase I Clinical Experience with Intravenous Administration of PV701, an Oncolytic Virus
A. Pecora, R. Lorence
20074 citations
Semantic Scholar
Slow intravenous infusion of PV701, an oncolytic virus: Final results of a phase I study
S. Hotte, P. Major, H. Hirte, S. Polawski +6 more
20044 citations
Semantic Scholar
An intravenous phase I trial of PV701, a replication-competent virus, in the treatment of patients with advanced solid cancers
R. Lorence, A. Pecora, N. Rizvi, G. Cohen +7 more
20014 citations
Semantic Scholar
BI 905711, a TRAILR2/CDH17 Bispecific Antibody, Alone or with Chemotherapy for Patients with Advanced Gastrointestinal Cancers: Phase I Study Findings
James J. Harding, R. Hofheinz, E. Élez, Y. Kuboki +14 more
2026Cancer Research Communications3 citations Open access
Semantic Scholar

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