β-Blockers and Myasthenia Gravis

Letters1 December 1975β-Blockers and Myasthenia GravisY. HERISHANU, M.D., P. ROSENBERG, MB.CH.B.Y. HERISHANU, M.D., P. ROSENBERG, MB.CH.B.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-6-834 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPropranolol and other adrenergic β-blocking agents are widely used in medicine. Side effects such as hypotension, worsening or precipitation of congestive heart failure, or asthma are well known.In-vitro experiments by workers such as Werman and Wislicki (1) and Wislicki and Rosenblum (2) have shown that β-blockers are capable of a depressant effect on the neuromuscular junction.We saw three patients in whom it seemed to us that this phenomenon played an important role.Patient 1 was a woman aged 67 years who, because of hypertension, was receiving oxprenolol (Trasicor⌖), 30 mg/day. For 3 months before her appearance in our...References1. WERMANWISLICKI RL: Propranolol, a curariform and cholinomimetic agent at the frog neuromuscular junction. Comp Gen Pharmacol 2:69-81, 1971 CrossrefMedlineGoogle Scholar2. WISLICKIROSENBLUM LL: Effects of propranolol on the action of neuromuscular blocking drugs. Br J Anaesth 39:939-942, 1967 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Y. HERISHANU, M.D.; P. ROSENBERG, MB.CH.B.Affiliations: Neurology Unit Shaare Zedek Hospital 161 Jaffa Street, P.O. Box 293 Jerusalem 91-000, Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntibody Therapies in Autoimmune Neuromuscular Junction Disorders: Approach to Myasthenic Crisis and Chronic ManagementMedical Management of GlaucomaDrugs That Induce or Cause Deterioration of Myasthenia Gravis: An UpdateAnesthesia-Related Complications in Neuromuscular Disorders in AdultsMedical Management of GlaucomaMyasthenia Gravis and Crisis: Evaluation and Management in the Emergency DepartmentNew onset of myasthenia gravis after intravesical Bacillus Calmette-GuerinMyasthenia GravisEffects of drugs on neuromuscular junctionNeuromuscular DisordersNeurological Patients for NonneurosurgeriesMyasthenia gravis and heart failure: Is ivabradine a useful drug?Neurologic complications of arrhythmia treatmentMedikamenter som kan utløse og forverre myasthenia gravisPerioperative neurological disordersMedical Management of GlaucomaChapter 12 Neurotoxicology of neuromuscular transmissionSystemic adverse effects of beta-adrenergic blockers: an evidence-based assessmentPreoperative Preparation and Anesthetic Management of Patients With Myasthenia GravisANESTHESIA AND NEUROMUSCULAR DISEASESAcute effects of intravenous injection of beta-adrenoreceptor- and calcium-channel antagonists and agonists in myasthenia gravisMyasthenia gravis following iron chelation therapy with intravenous desferrioxaminePhaeochromocytoma associated with myasthenia gravis precipitated by propranolol treatmentOcular myasthenia: A protean disorderMyasthenia gravis by another name: An elusive imposterSystemic drug interactions with topical glaucoma medicationsEdrophonium responsiveness not necessarily diagnostic of myasthenia gravisNeuromuskuläre Erkrankungen mit MyokardbeteiligungRespiratory Failure Produced by Severe Procainamide Intoxication in a Patient with Preexisting Peripheral Neuropathy Caused by AmiodaroneBeta-adrenergic receptor blockers. Adverse effects and drug interactions.Preoperative Management of the Surgical Patient with Neurologic DiseaseAntianginal and β-adrenoceptor blocking drugsWorsening of myasthenia gravis with timolol maleate eyedropsOCULAR TOXICOLOGY UPDATEDRUG INTERACTIONS IN ANTIARRHYTHMIC THERAPYDrugs that may exacerbate myasthenia gravisMendelian Predisposition to LymphomagenesisAlterations of Drug Toxicity in Neuropsychiatric Disease StatesDrug-induced disorders of muscleBETA-ADRENORECEPTOR ANTAGONISTS AND DIPLOPIABeta blockers in ophthalmologyDisorders of neuromuscular transmission other than myasthenia gravisDisorders of Neuromuscular Transmission Caused by DrugsDRUG-INDUCED MYOPATHIES IN MANMyasthenia gravis: Review of diagnosis and managementMuskelschwäche als Leit- oder Warnsymptom unter medikamentöser Therapie und bei Intoxikationen 1 December 1975Volume 83, Issue 6Page: 834-835KeywordsAsthmaHeart failureHypertensionHypotensionMyasthenia gravis ePublished: 1 December 2008 Issue Published: 1 December 1975 PDF downloadLoading ...