[Successful pregnancy after allogeneic bone marrow transplantation: two case reports].
N Hirabayashia, S Goto, Chiho Isogai, Akihiro Tomita, Tatsuharu Ohno
- aDepartment of Hematology, Nagoya Daini Red Cross Hospital
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Abstract
A case of successful pregnancy after allogeneic bone marrow transplantation (BMT) in a woman with severe aplastic anemia conditioned with 200 mg/kg cyclophosphamide and 4.5 Gy total lymphoid irradiation (TLI) at the age of 15 years is reported. She delivered a normal child 92 months after BMT. A male with paroxysmal nocturnal hemoglobinuria received allogeneic BMT at the age of 22 years is described as a second case. He was conditioned with 200 mg/kg CY and 7.5 Gy TLI and parented a normal child 32 months after BMT. These observations demonstrate that normal pregnancy can follow high dose chemotherapy and TLI.