article
Lisuride hydrogen maleate: An ergoline with β-adrenergic antagonist activity
Thomas Cotea, Masahide MUNEMURAa, John W. Kebabiana
- aExperimental Therapeutics Branch, National Institute of Neurlogical and Communicative Disorders and Stroke, Building 10, Room 6D16, National Institutes of Health, Bethesda, Maryland, 20205, U.S.A
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Abstract
Lisuride hydrogen maleate is identified as a potent beta-adrenergic antagonist using a hormone-sensitive adenylate cyclase system and [3H]dihydroalprenolol binding in cell free homogenates of rabbit cerebellum. Lisuride and two other ergolines, lergotrile and bromocriptine, and the phenothiazine, fluphenazine, all interact with spiroperidol binding sites (dopamine receptors) in the anterior pituitary; however, among these compounds lisuride is unique in its ability to antagonize the beta-adrenoceptor.