Statins exert anti-growth effects by suppressing YAP/TAZ expressions via JNK signal activation and eliminate the immune suppression by downregulating PD-L1 expression in pancreatic cancer.
Norio Uemuraa, Hiromitsu Hayashia, Zhao Liua, Kazuki Matsumuraa, Yoko Ogataa, Noriko Yasudaa, Hiroki Satoa, Yuta Shiraishia, Tatsunori Miyataa, Shigeki Nakagawaa, Kosuke Mimaa, Hidetoshi Nittaa, Hideo Babaa
- aDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University Kumamoto, Japan
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Abstract
. In conclusion, Statins display two distinct anti-cancer effects (direct anti-growth effect and elimination of immune suppression by downregulating PD-L1 expression) by targeting YAP/TAZ expression.
TL;DRIt is found that statin intake was associated with favorable prognostic outcomes in patients with resectable pancreatic cancer and display two distinct anti-cancer effects (direct anti-growth effect and elimination of immune suppression by downregulating PD-L1 expression) by targeting YAP/TAZ expression. (Semantic Scholar)