Transcriptomic and functional pathway features were associated with survival after pathological complete response to neoadjuvant chemotherapy in breast cancer.
Takashi Takeshitaa b, Li Yanc d, Xuan Pengc d, Siker Kimbunge, Thomas Hatschekf, Ingrid A. Hedenfalke, Omar Maen Rashidg h i j, Kazuaki Takabea k l m n o
- aBreast Surgery, Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center Buffalo, NY, USA
- bBreast Surgery, Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA
- cDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center Buffalo, NY, USA
- dDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA
- eDivision of Oncology, Department of Clinical Sciences and Lund University Cancer Center, Lund University Lund, Sweden
- fBreast Center, Karolinska University Hospital and Department of Oncology-Pathology, Karolinska Institutet Solna, Sweden
- gHoly Cross Hospital Michael and Dianne Bienes Comprehensive Cancer Center Fort Lauderdale, Florida, USA
- hDepartment of Surgery, Massachusetts General Hospital Boston, Massachusetts, USA
- iDepartment of Surgery, University of Miami Miller School of Medicine Miami, Florida, USA
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Abstract
expressing tumors have significantly worse overall survival in TCGA BC cohort. We demonstrated the genes and functional pathway features associated with pCR and survival utilizing the bioinformatics approach to public BC cohorts. Some genes involved in recurrence after pCR due to NAC also served as prognostic factors in primary BC.
TL;DRThe genes and functional pathway features associated with pCR and survival are demonstrated utilizing the bioinformatics approach to public BC cohorts and some genes involved in recurrence after pCR due to NAC also served as prognostic factors in primary BC. (Semantic Scholar)