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Frequency and types of deletional α+ in Northern Sardinia

Anna Di Rienzo^a, Luciano Felicetti^a, Andrea Novelletto^b, Gavino Forteleoni^c, Bruno Colombo^a

^aIstituto di Biologia Cellulare, C.N.R., Via G.D. Romagnosi 18/A, 00196, Roma, Italy
^bDipartimento di Biologia, II Università di Roma, Italy
^cClinica Pediatrica, Università di Sassari, Italy

Human Genetics Springer Science+Business Media1985-10-01 12 citations10 references

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Abstract

We determined by restriction mapping the frequency of the -alpha 3.7 determinant in a random sample of 48 adults in Northern Sardinia. We found a frequency of 0.18 +/- 0.04 and demonstrated that only type I crossover as determined by Apa I digestion (Higgs et al. 1984) is present. Moreover, we showed that this haplotype is not associated with an Rsa I polymorphism 5' to the alpha 2-globin gene. These data support the hypothesis of a unique origin of this deletion in Sardinia.

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Frequency and types of deletional α+ in Northern Sardinia

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