Aging. Programmed change.
Forciea Maa b✉
- aProgram in Geriatric Medicine, University of Pennsylvania, School of Medicine, Philadelphia
- bProgram in Geriatric Medicine, University of Pennsylvania School of Medicine, Philadelphia
- ✉Corresponding author
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Abstract
Is aging due to random change or to a developmental program? This fundamental question motivates much research in gerontology and focuses clinical geriatrics research in different directions, as well. If aging changes are random, the prevalence and natural history of disease in the elderly might be unpredictable. Alternatively, if a developmental program continues to operate in late life, physiologic changes could predispose to certain disease or influence therapy in predictable ways. This article argues that the physiology of aging does result from a genetic program that continues to operate in late life.
TL;DRIt is argued that the physiology of aging does result from a genetic program that continues to operate in late life that predispose to certain disease or influence therapy in predictable ways. (Semantic Scholar)