article
Detection of 17 α ‐hydroxyprogesterone caproate in equine plasma by gas chromatography/tandem mass spectrometry
Andrew R. McKinneya b✉, Craig J. Suannc, Allen M. Stenhouseb
- aAustralian Racing Forensic Laboratory, P.O. Box 528, Kensington, NSW 1465, Australia. amckinney@racingnsw.com.au
- bAustralian Racing Forensic Laboratory, P.O. Box 528, Kensington, NSW 1465, Australia
- cRacing New South Wales, P. O. Box 528, Kensington, NSW 1465, Australia
- ✉Corresponding author
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Abstract
A method was developed for the analysis of the synthetic progestin 17alpha-hydroxyprogesterone caproate in equine plasma following its administration by intramuscular injection. The method employed a reversed-phase solid-phase extraction followed by enol-trimethylsilylation and analysis by gas chromatography/tandem mass spectrometry. The intact ester was detectable in the plasma for up to 2 weeks after a single therapeutic dose, and was found to be stable in equine whole blood for at least 2 months.