Thyrotoxic periodic paralysis with bone metabolism disruption: a case report
Longying Wanga, Dong Luob, Dalian Wangc, Ping Lid, Yan Liua, Zhilong Liue
- aDepartment of Laboratory Medicine, Dazhou Integrated Traditional Chinese Medicine & Western Medicine Hospital, Dazhou Second People’s Hospital, Dazhou, China
- bDepartment of Emergency , Dazhou Integrated Traditional Chinese Medicine and Western Medicine Hospital , Dazhou Second People's Hospital , Dazhou , China
- cDepartment of Ultrasound, Dazhou Integrated Traditional Chinese Medicine & Western Medicine Hospital, Dazhou Second People’s Hospital, Dazhou, China
- dCenter for Medical Imaging, Dazhou Integrated Traditional Chinese Medicine & Western Medicine Hospital, Dazhou Second People’s Hospital, Dazhou, China
- eDepartment of Laboratory Medicine, Dazhou Integrated Traditional Chinese Medicine & Western Medicine Hospital, Dazhou Second People’s Hospital
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Abstract
Thyrotoxic Periodic Paralysis (TPP) is a rare condition associated with hyperthyroidism, particularly in young males. This report presents the case of a 20-year-old male with TPP complicated by decreased bone mineral density (BMD). While TPP is primarily a neuromuscular disorder characterised by hypokalaemia-induced periodic paralysis, this case highlights the less-recognised impact of prolonged hyperthyroidism on bone metabolism, resulting in significant bone loss. The patient was treated with potassium supplementation, antithyroid therapy, and alendronate sodium to address bone metabolism. This case underscores the importance of comprehensive management in TPP, emphasising early diagnosis and incorporation of bone health monitoring to mitigate long-term complications such as osteoporosis. Keywords: Thyrotoxic Periodic Paralysis; Graves' disease; Hypokalaemia; Bone metabolism disorder.