Predictors of Composite Clinical Improvement in Heart Failure with Reduced Ejection Fraction: A Retrospective Cohort Study from Bangladesh
Mohammad Ashiqul Haquea, Samsun Nahara, NAM Momenuzzamana, Shuvodip Chandraa, Md Helal Uddin, Sheikh Fahim Shahriar, Sayema Afroz Eva, Faroque Md Mohsinb c✉, Reazur Rahmana
- aDepartment of Cardiology , Continental Hospital , Dhaka , Bangladesh
- bDepartment of Public Health , North South University , Dhaka , Bangladesh
- cResearch Rats , Dhaka , Bangladesh
- ✉Corresponding author
Papers open inside SciRah from the original publisher or repository; SciRah never hosts them.
Abstract
Background: Heart failure with reduced ejection fraction (HFrEF) is a major global health challenge, with an increasing burden in low- and middle-income countries despite advances in therapy. Evidence regarding predictors of therapeutic recovery in Bangladeshi populations remains limited. This study aimed to identify independent baseline predictors of composite clinical improvement (CCI) in a large Bangladeshi cohort with HFrEF. Methods: We conducted a retrospective observational cohort study of 1075 adult patients with HFrEF (LVEF Results: Among 1075 patients (mean age 58.0 ± 25.1 years; 14.2% female), 503 (46.8%) achieved CCI. Multivariable analysis demonstrated that younger age (odd ratio; OR = 0.91 per 10-year increase, p 2 increase, p Conclusions: Our findings support the real-world associations between contemporary HFrEF therapies, including ARNI and SGLT2 inhibitors, and improved clinical outcomes in resource-limited settings. Future prospective research is required to confirm these benefits while accounting for confounding by indication inherent in observational registry data.