Association of Serum Resistin with Insulin Sensitivity in Self Reported Healthy Individuals of Pakistan: A Cross-Sectional Study

Objectives: In current study, it was aimed to evaluate relationship between level of serum resistin and some metabolic and anthropometric parameters of healthy individuals. Methods: Eighty healthy subjects with mean body mass index of 25 kg/m2 or greater were added. Waist to hip ratio, body mass index, weight and height were calculated as anthropometric parameters. Lipid profiles, blood insulin level, plasma glucose level, fasting serum resistin and insulin resistance (by homeostasis model assessment, HOMA) were measured as metabolic parameters. Results: The results showed no correlation between markers and serum resistin level for uric acid level, glucose, blood pressure and adiposity. Level of serum resistin did not correlate with HOMA and fasting insulin level in women only and with high-density lipoprotein cholesterol level in men only. HDL-C level was an independent significant predictor for resistin in men only and HDL-C level and HOMA were independent significant predictors for resistin in women only, revealed by multiple linear regression analysis using the logarithm of resistin as a dependent variable. Conclusion: In summary, resistin was not linked to the majority of lipid profiles, insulin resistance, blood pressure, obesity, or fasting plasma glucose levels. For both men and women, resistin had a negative correlation with HDL-C levels. More research is necessary to fully understand the role of resistin in metabolic syndrome.