The Potential of Coenzyme Q10 in Alzheimer's Disease: Reducing IL-17 Induced Inflammation and Oxidative Stress for Neuroprotection
Himanshu Sharmaa✉, Sumaiya Binte Ibrahimb, Abdullah Al Nomanb, Umme Fathima Tuz Zohorab, Farhana Akter Shifab, Samira Siddikab, Sadia Tasneemb, Md Al Azadc, Rashmi Pathakd
- aTeerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad (UP), 244001, India
- bSchool of Pharmacy, BRAC University, Dhaka, 1212, Bangladesh
- cDepartment of Pharmacy, Jahangirnagar University, Savar, Dhaka, Bangladesh
- dDepartment of Pharmacy, Invertis University, Bareilly (UP), 243123, India
- ✉Corresponding author
Papers open inside SciRah from the original publisher or repository; SciRah never hosts them.
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder primarily marked by amyloid-beta (Aβ) plaque accumulation and neurofibrillary tangles, which lead to cognitive decline. Oxidative stress and neuroinflammation are key contributors to the disease's progression, with elevated production of Reactive Oxygen Species (ROS) exacerbating neuronal damage. Coenzyme Q10 (CoQ10), a naturally occurring antioxidant, has been identified for its potential neuroprotective effects due to its roles in mitochondrial function, energy production, and antioxidant defense. The cytokine interleukin-17 (IL-17) is also implicated in AD, promoting neuroinflammation by disrupting the blood-brain barrier (BBB) and activating glial cells. This review explores the impact of CoQ10 on neuroinflammation and oxidative stress in AD, focusing on its role in mitigating IL-17-mediated pathways. Preclinical studies indicate that CoQ10 reduces Aβ plaques, improves cognitive functions, and restores mitochondrial stability. However, clinical trials have yielded mixed results, often limited by bioavailability challenges. This research highlights the necessity of further human trials better to understand CoQ10's therapeutic potential in AD management.
TL;DRThe necessity of further human trials better to understand CoQ10's therapeutic potential in AD management is highlighted, highlighting the necessity of further human trials better to understand CoQ10's therapeutic potential in AD management. (Semantic Scholar)