Orthostatic Hypotension in Benign Prostatic Hyperplasia Patients and Its Association With Alpha-1 Antagonist Use: A Comprehensive Literature Review
Muhammad Abubakara b, Rachna Prasadc, Siffat Saima Salimd, Deepak Basavarajue, Munazza Khanf, Ibrahim Khaleel Lateeff, Furqan Ahmadg, Saud Razaa, Ishita Guptah, Deepak Kumar Singlai, Hira Adilj, Ather Naeemk
- aDepartment of Internal Medicine, Ameer-ud-Din Medical College, Lahore General Hospital, Lahore, PAK
- bDepartment of Internal Medicine, Siddique Sadiq Memorial Trust Hospital, Gujranwala, PAK
- cDepartment of Internal Medicine, Stanley Medical College, Chennai, IND
- dDepartment of Surgery, Holy Family Red Crescent Medical College Hospital, Dhaka, BGD
- eDepartment of Internal Medicine, Mysore Medical College and Research Institute, Mysore, IND
- fDepartment of Internal Medicine, Medical University Pleven, Pleven, BGR
- gDepartment of Internal Medicine, Lahore Medical and Dental College, Lahore, PAK
- hDepartment of Internal Medicine, Dr. Baba Saheb Ambedkar Medical College and Hospital, New Delhi, IND
- iDepartment of Internal Medicine, Government Medical College, Patiala, Patiala, IND
- jDepartment of Community Medicine, Khyber Girls Medical College, Peshawar, PAK
- k
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Abstract
Orthostatic hypotension (OH) is frequently observed in benign prostatic hyperplasia (BPH) patients undergoing alpha-1 adrenergic antagonist (A1AA) therapy. While previous studies have acknowledged the prevalence of OH in BPH patients on A1AAs, limited data exist on ranking the safety of different A1AAs. This comprehensive review explores the underlying mechanisms of OH, examines numerous factors influencing its development, and provides insights into effective treatment strategies such as hydration, gradual postural changes, leg exercises, compression stockings, and tilt-table training for BPH management. The review highlights the significance of individualized care, interdisciplinary collaboration, and further research to optimize A1AA treatment, improve patient outcomes, and enhance quality of life.
TL;DRA comprehensive review explores the underlying mechanisms of OH, examines numerous factors influencing its development, and provides insights into effective treatment strategies such as hydration, gradual postural changes, leg exercises, compression stockings, and tilt-table training for BPH management. (Semantic Scholar)