Novel Antimicrobial Iodo-Dihydro-Pyrrole-2-One Compounds
Cristina Maria Al Matarneha b c, Alina Florica Nicolescud e, Ioana Cristina Marinașc, Mariana Carmen Chifiriucc, Sergiu G. Shovaf g, Mihaela Silionh i j, Mariana Pintealăa b
- aCenter of Advanced Research in Bionanoconjugates &
- bBiopolymers “Petru Poni” Institute of Macromolecular Chemistry of Romanian Academy 41A Grigore Ghica Voda Alley Iasi 700487 Romania
- cResearch Institute of the University of Bucharest-ICUB 91-95 Spl. Independentei Bucharest 050095 Romania
- dNMR Laboratory “Petru Poni” Institute of Macromolecular Chemistry of Romanian Academy 41A Grigore Ghica Voda Alley Iasi 700487 Romania
- eNMR Laboratory "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, 41A Grigore Ghica Voda Alley, Iasi, 700487, Romania
- fDepartment of Inorganic Polymers “Petru Poni” Institute of Macromolecular Chemistry of Romanian Academy 41A Grigore Ghica Voda Alley Iasi 700487 Romania
- gDepartment of Inorganic Polymers "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, 41A Grigore Ghica Voda Alley, Iasi, 700487, Romania
- hPhysics of Polymers &
- iPolymeric Materials Department “Petru Poni” Institute of Macromolecular Chemistry 41A Grigore Ghica Voda Alley Iasi 700487 Romania
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Abstract
Aim: A series of new hybrid molecules with two iodine atoms on the sides were synthesized. Methods: A one-pot, two-component method with trifluoroacetic acid as an effective catalyst to obtain dihydro-pyrrol-2-one compounds was developed. Short reaction times, a cheap catalyst, high yields and clean work-up are benefits of this method. Results: The chemical structures of the newly synthesized compounds were verified through spectroscopic techniques. Their antimicrobial activity against S. aureus, P. aeruginosa and C. albicans was tested in vitro. Conclusion: NC- and OH- radicals confer broad-spectrum antimicrobial activity, including against Gram-positive and Gram-negative bacteria and yeasts. Compounds 3g >7 and >9 were most active on the two bacterial species, while 3l >9 and >3i were most active against the fungal strain.