Design, synthesis, anticancer activity and molecular docking studies of new benzimidazole derivatives bearing 1,3,4-oxadiazole moieties as potential thymidylate synthase inhibitors
Abdulraheem S. A. Almalkia, Syed Nazreenb✉, Serag Eldin I. Elbehairic d, Mohammad Asade f, Ali Abdullah Shatid, Mohammad Yahya Alfaifid, A. Alhadhramia, Ahmed A. Elhenawyb g, Ali Q. Alorabib, Abdullah Mohamed Asirie f, Mohammad Mahboob Alamb✉
- aDepartment of Chemistry, Faculty of Science, Taif University, Taif, Kingdom of Saudi Arabia
- bDepartment of Chemistry, Faculty of Science, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia
- cCell Culture Laboratory, Egyptian Organization for Biological Products and Vaccines, VACSERA Holding Company, Giza 2311, Egypt
- dDepartment of Biology, Faculty of Science, King Khalid University, Abha 9004, Saudi Arabia
- eCenter of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
- fChemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
- gChemistry Department, Faculty of Science, Al-Azhar University, 11884 Nasr City, Cairo, Egypt
- ✉Corresponding author
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Abstract
The present work describes the synthesis and anticancer activity of new benzimidazole derivatives bearing 1,3,4-oxadiazoles as thymidylate synthase inhibitors. The newly synthesized molecules were confirmed by NMR, mass, FT-IR and...
TL;DRThe synthesis and anticancer activity of new benzimidazole derivatives bearing 1,3,4-oxadiazoles as thymidylate synthase inhibitors are described and confirmed by NMR, mass, FT-IR and... (Semantic Scholar)