Th22 cytokines and yellow fever: Possible implications for the immunopathogenesis of human liver infection
Caio Cesar Henriques Mendesa, Jorge Rodrigues de Sousaa b, Fábio Alves Olímpioc, Luiz Fábio Magno Falcãoa, Marcos Luiz Gaia Carvalhob, Jeferson da Costa Lopesb, Arnaldo Jorge Martins Filhob, Vanessa do Socorro Cabral Mirandab, Lais Carneiro dos Santosb, Fellipe Souza da Silva Vilacoertb, Vanessa Costa Alves Galúciod, Raimunda do Socorro da Silva Azevedob, Lívia Carício Martinsb, Maria Irma Seixas Duartee, Pedro Fernando da Costa Vasconcelosa f✉, Juarez Antônio Simões Quaresmab c g✉
- aUniversidade do Estado do Pará, Belém, PA, Brazil
- bInstituto Evandro Chagas, Ministério da Saúde, Ananindeua, PA, Brazil
- cUniversidade Federal do Pará, Belém, PA, Brazil
- dFaculdade Cosmopolita, Belém, PA, Brazil
- eUniversidade de São Paulo, São Paulo, SP, Brazil
- fInstituto Evandro Chagas, Ministério da Saúde, Ananindeua, PA, Brazil. Electronic address: pedro.vasconcelos@uepa.br
- gUniversidade de São Paulo, São Paulo, SP, Brazil. Electronic address: juarez@ufpa.br
- ✉Corresponding author
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Abstract
Yellow fever (YF) is an infectious disease considered a public health problem in tropical and subtropical areas. YF has many pathophysiological events that are correlated with the host immune response. In this study, the in situ Th22 cytokine profile was evaluated. Liver tissue samples were collected from 21 YFV-positive patients who died of the disease and five flavivirus-negative controls who died of other causes and whose hepatic parenchyma architecture was preserved. Immunohistochemical (IHC) analysis of tissues in the hepatic parenchyma of YF cases showed significantly higher expression of interleukin (IL)-22, IL-13, tumour necrosis factor-alpha, and FGF basic (FGF b) in YFV-positive cases than that in flavivirus-negative controls. These results indicate that the response of Th22 cytokines emerges as an alternative for a better understanding of adaptive immunity in the hepatic parenchyma, highlighting the role of cytokines in the repair and suppressive responses in the immunopathogenesis of YFV infection.
TL;DRAnalysis of tissues in the hepatic parenchyma of YF cases showed significantly higher expression of interleukin (IL)-22, IL-13, tumour necrosis factor-alpha, and FGF basic (FGF b) in YFV-positive cases than that in flavivirus-negative controls. (Semantic Scholar)