Hepato-pathological hallmarks for the surveillance of Yellow Fever in South American non-human primates
Pedro Henrique de Oliveira Passosa b, Daniel Garkauskas Ramosb, Alessandro Romanob, Karina Ribeiro Leite Jardim Cavalcanteb, Luisa Helena Monteiro de Mirandac, Janice Mery Chicarino Coelhod, Ramona C. Barrose, Arnaldo Jorge Martins Filhof, Juarez Antônio Simões Quaresmae, Isabel Luana de Macêdoa g, Taís Meziara Wilsona g, Davi Emanuel Ribeiro de Sousaa g, Cristiano Barros de Meloa, Márcio Botelho de Castroa g h✉
- aGraduate Program in Animal Science, University of Brasília, Federal District, Brasilia, Brazil
- bBrazilian Ministry of Health, Federal District, Brasilia, Brazil
- cThe University of Sydney, Sydney, New South Wales, Australia
- dFundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil
- eUniversidade do Estado do Pará, Belém, Pará, Brazil Veterinary
- fInstituto Evandro Chagas, Belém, Pará, Brazil
- gVeterinary Pathology Laboratory, University of Brasília, Federal District, Brasília, Brazil
- hVeterinary Pathology Laboratory, University of Brasília, Federal District, Brasília, Brazil. Electronic address: mbcastro@unb.br
- ✉Corresponding author
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Abstract
The early detection and diagnosis of deaths in free-ranging non-human primates (NHPs) are key points for the surveillance of Yellow Fever (YF) in Brazil. The histopathological identification of infectious diseases remains very useful and reliable in the screening and detection of emerging zoonotic diseases such as YF. We surveyed data records and liver slides stained with hematoxylin and eosin from the Epizootics Surveillance Network to control YF, Ministry of Health of Brazil, to evaluate histopathological hallmarks for the diagnosis of the YF virus infection. We selected natural fatal cases in NHPs from the genera Alouatta spp., Callithrix spp., and Sapajus spp. with a positive immunohistochemical assay for YF in liver samples. Our findings showed the full-spectrum YF-associated hepatic lesions in all NHPs, but some histopathological findings differed in the distribution and intensity between the three genera. In our study, South American NHPs showed significant differences in the YF-associated hepatic histopathological features compared to fatal cases reported in humans.
TL;DRSouth American NHPs showed significant differences in the YF-associated hepatic histopathological features compared to fatal cases reported in humans, but some histopathology findings differed in the distribution and intensity between the three genera. (Semantic Scholar)