Molecular investigation of possible relationships concerning bovine leukemia virus and breast cancer
Zanib Khana, Muhammad Abubakarb, Muhammad Javed Arshedb, Roohi Aslamc, Sadia Sattara, Naseer Ali Shaha, Sundus Javeda, Aamira Tariqa, Nazish Bostana d✉, Shumaila Manzoorb
- aBiosciences Department, COMSATS University, Islamabad, Pakistan
- bNational Veterinary Laboratory, Park Road, Islamabad, Pakistan
- cNUTECH School of Applied Sciences and Humanities, National University of Technology, Islamabad, Pakistan
- dBiosciences Department, COMSATS University, Islamabad, Pakistan. nazishbostan@comsats.edu.pk
- ✉Corresponding author
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Abstract
Worldwide, breast cancer has an eminent morbidity and mortality rate, as it is a neoplastic disease among females. The query of the prospective danger of bovine leukemia virus (BLV) to humans is an old but exceedingly topical focus of scientific debate. The objective of the current study was to determine the possible relationship between BLV and breast cancer. A total of 2710 formalin-fixed paraffin-embedded (FFPE) breast cancer samples were selected regardless of the age, ethnicity, or municipality origin of the subjects. The presence of BLV in human breast cancer was determined through nested PCR by amplifying tax and gag genes followed by partial sequencing. Homology was confirmed by using the online BLAST Tool. BLV genes were found to be positive in 26.8% (728/2710) of the samples from breast cancer patients and 10% (10/80) of the samples without cancer (negative control). The results indicated a correlation between the presence of the BLV gene and breast cancer (odds ratio = 0.3889; confidence interval = 1,18; p = 0.0029). The current findings suggest a possible link between BLV and human breast carcinoma. Therefore, screening cattle herds and milk products is suggested to reduce the viral transmission risk to humans.
TL;DRA possible link between bovine leukemia virus (BLV) and human breast carcinoma is suggested and screening cattle herds and milk products is suggested to reduce the viral transmission risk to humans. (Semantic Scholar)