Relationship between Central Obesity and the incidence of Cognitive Impairment and Dementia from Cohort Studies Involving 5,060,687 Participants
Xingyao Tanga, Wei Zhaob, Ming Lüc, Xin Zhangc, Ping Zhangc, Xin Zhongc, Ran Sunc, Wei Tiana, Marly Augusto Cardosod, Jinkui Yangc, Rafael Simóe f, Jianbo Zhouc g✉, Coen D.A. Stehouwerh
- aBeijing Tongren Hospital, Capital Medical University, Beijing, China
- bDepartment of Geriatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, China
- cDepartment of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
- dDepartment of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil
- eEndocrinology and Nutrition Department, Hospital Universitari Vall d'Hebron. Diabetes and Metabolism Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Passeig de la Vall d'Hebron, 119, 08035, Barcelona, Spain
- fCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
- gDepartment of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address: jbzhou@ccmu.edu.cn
- hDepartment of Internal Medicine and CARIM School for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, the Netherlands
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Abstract
Central obesity, measured by the waist circumference (WC) or waist-to-hip ratio, has been linked with metabolic dysfunction and structural abnormalities in the brain, two risk factors for cognitive impairment and dementia. The current analysis was performed to understand the influence of central obesity on the incidence of cognitive impairment and dementia. It included 21 studies involving 5,060,687 participants and showed that a high WC was associated with a greater risk of cognitive impairment and dementia (HR = 1.10, 95 % CI: 1.05-1.15), compared with a low WC. Sub-group analysis showed that a high WC increased the likelihood of developing cognitive impairment and dementia in individuals older than 65 years of age (HR = 1.13, 95 % CI: 1.08-1.19), whereas no association was observed in individuals younger than 65 years of age (HR = 1.04, 95 % CI: 0.93-1.16). Furthermore, dose-response meta-analysis confirmed that a high WC was a risk factor for cognitive impairment and dementia. In conclusion, central obesity, as measured by WC, was associated with a risk of cognitive impairment and dementia.
TL;DRIt is shown that central obesity, as measured by WC, was associated with a risk of cognitive impairment and dementia and dose-response meta-analysis confirmed the finding that a high WC was a risk factor for cognitive impaired and dementia. (Semantic Scholar)