[6]‐Gingerol Inhibits Chikungunya Virus Infection by Suppressing Viral Replication
Rahma Hayatia, Cynthia D. Betterb, Dionisius Denisa, Amalina Ghaisani Komarudina, Anom Bowolaksonoc, Benediktus Yohana, R. Tedjo Sasmonoa✉
- aEijkman Institute for Molecular Biology, Ministry of Research and Technology/National Agency for Research and Innovation, Jl. Diponegoro 69, Jakarta 10430, Indonesia
- bFaculty of Pharmacy, University of Strasbourg, 4 Rue Blaise Pascal, Strasbourg 67081, France
- cCellular and Molecular Mechanisms in Biological System Research Group, Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, West Java, Indonesia
- ✉Corresponding author
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Abstract
Chikungunya (CHIK) is a reemerging arboviral disease caused by chikungunya virus (CHIKV) infection. The disease is clinically hallmarked by prolonged debilitating joint pain. Currently, there is no specific antiviral medication nor commercial vaccine available for treatment of the disease, which makes the discovery or development of specific anti‐CHIKV compounds a priority. Ginger (Zingiber officinale Roscoe) is widely known for its various health benefits. The compound [6]‐gingerol is the main active ingredient found in ginger. This study sought to determine the potential of [6]‐gingerol antiviral activity against CHIKV infection using in vitro human hepatocyte HepG2 cells. The antiviral activity mechanism was investigated using direct virucidal and four indirect (pre‐, post‐, full‐, and prevention) treatment assays. [6]‐Gingerol showed weak virucidal activity but significant indirect antiviral activity against CHIKV through post‐ and full treatment with IC50 of 0.038 mM and 0.031 mM, respectively, without showing cell cytotoxicity. The results indicated that [6]‐gingerol inhibits CHIKV infection through suppression of viral replication. Together, this study confirms the potential use of [6]‐gingerol for CHIK antiviral compound.
TL;DRThe results indicated that [6]-gingerol inhibits chikungunya virus infection through suppression of viral replication, which confirms the potential use of [6], Gingerol for CHIK antiviral compound. (Semantic Scholar)