Wnt/β-catenin Pathway-Mediated PPARδ Expression during Embryonic Development Differentiation and Disease
Tabinda Sidrata, Zia Ur Rehmanb, Myeong‐Don Jooa, Kyeong‐Lim Leec, Il‐Keun Konga c d✉
- aDepartment of Animal Science, Division of Applied Life Science (BK21 Four), Gyeongsang National University, Jinju 52828, Korea
- bDepartment of Microbiology, Hazara University, Mansehra 21310, Pakistan
- cThe King Kong Corp. Ltd., Gyeongsang National University, Jinju 52828, Korea
- dInstitute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Korea
- ✉Corresponding author
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Abstract
The Wnt/β-catenin signaling pathway plays a crucial role in early embryonic development. Wnt/β-catenin signaling is a major regulator of cell proliferation and keeps embryonic stem cells (ESCs) in the pluripotent state. Dysregulation of Wnt signaling in the early developmental stages causes several hereditary diseases that lead to embryonic abnormalities. Several other signaling molecules are directly or indirectly activated in response to Wnt/β-catenin stimulation. The crosstalk of these signaling factors either synergizes or opposes the transcriptional activation of β-catenin/Tcf4-mediated target gene expression. Recently, the crosstalk between the peroxisome proliferator-activated receptor delta (PPARδ), which belongs to the steroid superfamily, and Wnt/β-catenin signaling has been reported to take place during several aspects of embryonic development. However, numerous questions need to be answered regarding the function and regulation of PPARδ in coordination with the Wnt/β-catenin pathway. Here, we have summarized the functional activation of the PPARδ in co-ordination with the Wnt/β-catenin pathway during the regulation of several aspects of embryonic development, stem cell regulation and maintenance, as well as during the progression of several metabolic disorders.
TL;DRThe functional activation of the PPARδ in co-ordination with the Wnt/β-catenin pathway is summarized during the regulation of several aspects of embryonic development, stem cell regulation and maintenance, as well as during the progression of several metabolic disorders. (Semantic Scholar)