Atropine Induced Psychosis in Organophosphate Insecticide Poisoning and it's Management: A case series
Shoaib Asghara b, Junaid Mustafac, Moeen Akhtar Malikd, Sohaib Asghara b, Habib ur Rehmanc, Nida Gohara
- aPGR, Department of Medicine, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, Pakistan
- bPostgraduate Resident, Department of Medicine-Unit II, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, Pakistan
- cAssistant Professor, Department of Medicine, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, Pakistan
- dAssociate Professor, Department of Medicine, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan
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Abstract
Atropine is an established antidote in organophosphorus poisoning. It is an anticholinergic that inhibits the muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites including secretory glands, smooth muscle, and CNS sites. In the literature, the cases of atropine intoxication are not uncommon. We report a case series of five cases of atropine induced psychotic disorder in patients, who manifested with delirium, hallucinations, nervousness, drowsiness, weakness, irrelevant talk, flushing along with tachycardia, and non-reactive dilated pupils suggesting possible anti-cholinergic abuse. The patients reported at the Department of Medicine-Unit II, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, from January to June 2019. The patients were managed symptomatically by titrating down the atropine's dose, administration of benzodiazepine, and antipsychotics.
TL;DRA case series of five cases of atropine induced psychotic disorder in patients, who manifested with delirium, hallucinations, nervousness, drowsiness, weakness, irrelevant talk, flushing along with tachycardia, and non-reactive dilated pupils suggesting possible anti-cholinergic abuse. (Semantic Scholar)