A review of the main histopathological findings in coronavirus disease 2019
Walter O. Vasquez-Bonillaa b, Roberto Orozcoa, Víctor Arguetaa, Manuel Sierrac, Lysien I. Zambranob d, Fausto Muñoz‐Larae f, Dennis Salomon Lopez Molinag h, Kovy Arteaga‐Liviasb i j, Zachary Grimesk, Clare Brycek, Alberto Paniz‐Mondolfib k l m n, Alfonso Javier Rodriguez-Moralesb j o p q✉
- aDepartment of Pathology, Hospital General San Juan de Dios, Guatemala City (Ciudad de Guatemala), 01001, Guatemala
- bLatin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia
- cCentral American Technological University, Francisco Morazán, Distrito Central, Tegucigalpa, 11101 Honduras
- dDepartment of Morphological Sciences, School of Medical, Sciences, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa, 11101, Honduras
- eDepartment of Internal Medicine, Hospital Escuela, Tegucigalpa, 11101, Honduras
- fDepartment of Internal Medicine, School of Medical, Sciences, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa, 11101, Honduras
- gInstitute Pasteur, Paris, 75008, France
- hHealth Biology: Microbiology and Immunology, Faculté de Sciences, Université de Montpellier, 34000, France
- iFacultad de Medicina, Universidad Nacional Hermilio Valdizán, Huánuco, 10160, Peru
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Abstract
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has been declared by the World Health Organization as an emerging public health problem of global importance and classified as a pandemic. SARS-CoV-2 infection can result in diverse, multiorgan pathology, the most significant being in the lungs (diffuse alveolar damage in its different phases, microthrombi, bronchopneumonia, necrotizing bronchiolitis, viral pneumonia), heart (lymphocytic myocarditis), kidney (acute tubular injury), central nervous system (microthrombi, ischemic necrosis, acute hemorrhagic infarction, congestion, and vascular edema), lymph nodes (hemophagocytosis and histiocytosis), bone marrow (hemophagocytosis), and vasculature (deep vein thrombosis). An understanding of the spectrum and frequency of histologic findings in COVID-19 is essential for gaining a better understanding of disease pathophysiology and its ongoing impact on public health. To this end, we conducted a systematic meta-analysis of histopathologic observations to date and review the reported findings.
TL;DRA systematic meta-analysis of histopathologic observations to date of coronavirus disease 2019 finds that an understanding of the spectrum and frequency of histologic findings in COVID-19 is essential for gaining a better understanding of disease pathophysiology and its ongoing impact on public health. (Semantic Scholar)