Ziprasidone-Induced Oculogyric Crisis in a 74-Year-Old Female
Alphonso Wilsona b c✉, Asia Filatova b c, Mishah Azhara b c, Marc A. Swerdloffa b c, Sameea Husain Wilsona b c
- aInternal Medicine, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA
- bNeurology, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, USA
- cNeurology, Marcus Neuroscience Institute, Boca Raton, USA
- ✉Corresponding author
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Abstract
Oculogyric crisis is a rare ocular dystonia first appearing at the turn of the last century in postencephalitic patients. In the modern era, they were most frequently associated with first-generation D1 dopaminergic receptor blocking antipsychotic medication. We present an unusual case of acute oculogyric crisis in a 74-year-old woman with long-standing Parkinson disease following exposure to the second-generation neuroleptic ziprasidone, which has dopaminergic (D2) and serotoninergic (5-HT2A) receptor blocking effects and is used for severe delusions and psychosis. To the best of our knowledge, there are no other published reports.