COMPARISON OF HEALING RATE OF ANAL FISSURE WITH 0.2% GLYCERYL TRINITRATE OINTMENT VERSUS 2% NIFEDIPINE OINTMENT
Usman Asghara, Raheel Khanb, Zahra Nigarc, Irfan Shukrd, Imran Gule
- aSWS Hospital Wanna, South Waziristan Agency, Pakistan
- bCombined Military Hospital, Dera Nawab Sahib (Pakistan)
- cCombined Military Hospital Multan/National University of Medical Sciences (NUMS) Pakistan
- dCombined Military Hospital/ National University of Medical Sciences (NUMS) Rawalpindi Pakistan
- e144 Medical Battalion, Goma Pakistan
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Abstract
Objective: To compare the efficacy of topical 0.2% glyceryl trinitrate (GTN) ointment with 2% Nifedipine ointment in healing of anal fissure. Study Design: Quasi experimental study. Place and Duration of Study: Department of Surgery, Combined Military Hospital (CMH) Dera Nawab Sahib, from Oct 2015 to Oct 2016. Methodology: A total of 330 patients were divided into two groups (group A and group B) with 165 patients in each group using lottery method. Patients in group A were treated with topical application of 0.2% glyceryl trinitrate ointment for four weeks while group B patients were treated with topical 0.2% nifedipine. Patients were followed up after four weeks of initiation of treatment and healing of fissure was assessed. Frequency of healing of fissure in both groups was calculated and compared. Results: Healing rate of anal fissure was found significantly higher in group B (79.4%) as compared to group A (63.6%). The p-value was found to be 0.002 which was statistically significant. However, gender had no effect on fissure healing (p-value 0.413). Conclusion: Topical 2% nifedipine ointment therapy was superior to 0.2% glyceryl trinitrate ointment in terms of healing of anal fissure.