Inhibitory Effect of Alpha-Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells
Zaenal Sugiyantoa b, Benediktus Yohanc, Soeharyo Hadisaputroa d, Edi Dharmanaa d, Catharina Suhartia d, Winarto Winartoa d, Kis Djamiatund, Fifin Luthfia Rahmid, R. Tedjo Sasmonoc e✉
- aDoctoral Program in Medical and Health Sciences, Faculty of Medicine, Diponegoro University, Jl. Prof. Sudarto SH, Tembalang, Semarang, 50275, Indonesia
- bFaculty of Health Science, Dian Nuswantoro University, Jl. Imam Bonjol 270, Semarang, 50131, Indonesia
- cEijkman Institute for Molecular Biology, Ministry of Research, Technology and Higher Education, Jl. Diponegoro 69, Jakarta, 10430, Indonesia
- dFaculty of Medicine, Diponegoro University, Jl. Prof. Sudarto SH, Tembalang, Semarang, 50275, Indonesia
- eEijkman Institute for Molecular Biology, Ministry of Research, Technology and Higher Education, Jl. Diponegoro 69, Jakarta, 10430, Indonesia. sasmono@eijkman.go.id
- ✉Corresponding author
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Abstract
Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue disease. The active compound of mangosteen fruit pericarps, α-mangostin, has been commonly used as traditional medicine and dietary supplement. We examined the effect of α-mangostin against dengue virus (DENV) infection in human peripheral blood mononuclear cells (PBMC) by the measurement of virus titer and TNF-α and IFN-γ cytokines concentration post infection. Increasing concentration of α-mangostin inhibited virus replication and reduced inflammatory cytokines expression at 24- and 48-h post infection. Our results support the potential use of α-mangostin as anti-antiviral and anti-inflammatory therapies in the treatment of dengue.
TL;DRThe results support the potential use of α-mangostin as anti-antiviral and anti-inflammatory therapies in the treatment of dengue. (Semantic Scholar)