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Background Idiopathic inflammatory myopathies (IIM) are characterised by inflammation and atrophy of skeletal muscles, pulmonary and articular involvement, which leads to functional impairment, reduced quality of life including sexual life. Objectives To assess sexual functions/quality of life and pelvic floor function in female IIM patients compared to age-/sex-matched healthy controls (HC). Methods In total, 22 women with IIM [mean age: 55.1, disease duration: 7.9 years, dermatomyositis (DM, 8)/polymyositis (PM, 10)/necrotizing myopathy (IMNM, 3)/inclusion body myositis (IBM, 1)], who fulfilled the Bohan/Peter 1975 criteria for DM/PM, and 22 healthy controls (mean age: 55.1 years) without rheumatic diseases filled in 12 well-established and validated questionnaires assessing sexual function/quality of life, pelvic floor function, fatigue, physical activity and depression. Data are presented as mean ±SEM. Results Compared to HC, patients with IIM had significantly higher prevalence and greater severity of sexual dysfunction (FSFI, BISF-W: in all subscales as well as total scores), dysfunction of pelvic floor (PISQ-12), and worse sexual quality of life (SQoL-F) (table 1). Worse scores in IIM patients were associated with elevated muscle enzyme levels [lactate dehydrogenase: FSFI (r=-0.524,p=0.0123), BISFW (r=-0.528,p=0.0115)], greater fatigue [FIS: FSFI (r=-0.434,p=0.0438), BISF-W (r=-0.488, p=0.0211), SQoL-F (r=-0.488,p=0.0070), PISQ-12 (r=0.643,p=0.0013)], more severe depression [BDI-II: PISQ-12 (r=0.474,p=0,0258)], deteriorated quality of life [HAQ: PISQ-12 (r=0.476,p=0.0252)], and worse ability to perform physical activities [HAP: FSFI (r=0.437,p=0.0417), BISF-W (r=0.451,p=0.0351), PISQ-12 (r=-0.494,p=0.0195)]. Questionnaire: score range Idiopathic inflammatory myopathies (n=22) Healthy controls(n=22) p-value FSFI: Female Sexual Function Index: 2(worst)−36(best) 14.2±2.7 23.5±2.5 p=0.0146 BISF-W: Brief Index of Sexual Function for Women: −16(worst)−75(best) 15.5±3.9 28.9±3.8 p=0.0193 PISQ–12: Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire short form: 0(best)−48(worst) 13.8±1.1 8.0±1.0 p=0.0003 PFIQ7: Pelvic Floor Distress Inventory Questionnaire – short form 7:0(best)−300(worst) 15.8±4.5 5.6±2.3 p=0.1450 SQoL-F: Sexual Quality of Life Questionnaire – Female: 0(worst)−100(best) 54.9±6.0 83.1±3.4 p-0.0006 FSS: Fatigue Severity Scale: 9(best)−63(worst) 46.9±2.8 26.7±2.5 p<0.0001 FIS: Fatigue Impact Scale: 0(best)−160(worst) 60.6±6.9 29.0±4.2 p=0.0003 MAF: Multidimensional Assessment of Fatigue Scale: 1(best)−50(worst) 26.1±2.3 17.8±1.4 p=0.0129 BDI-II: Beck’s Depression Inventory II: 0(best)−63(worst) 14.5±2.2 5.3±1.1 p=0.0003 HAP: Human Activity Profile – adjusted activity score: 0(worst)−94(best) 53.7±4.3 81.1±1.5 p<0.0001 HAQ: Health Assessment Questionnaire: 0(best)−3(worst) 1.0±0.2 0.0±0.0 p<0.0001 Conclusions Women with IIM reported significantly impaired sexual function, sexual quality of life and pelvic floor function than age-matched healthy controls. Worse scores in IIM were associated with disease activity, physical activity, fatigue, depression and quality of life. Acknowledgements Supported by AZV-16–33574A and MHCR 023728. Disclosure of Interest None declared
TL;DRPatients with IIM had significantly higher prevalence and greater severity of sexual dysfunction (FSFI, BISF-W), dysfunction of pelvic floor (PISQ-12), and worse sexual quality of life (SQoL-F) (table 1). (Semantic Scholar)