Mechanism of pattern recognition receptors (PRRs) and host pathogen interplay in bovine mastitis
Dinesh Bhattaraia b, Tesfaye Workub, Rahim Dadb, Zia Ur Rehmanb, Xiaoling Gongc, Shujun Zhangb d✉
- aKey Laboratory of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430071, China. Electronic address: dbhattarai@webmail.hzau.edu.cn
- bKey Laboratory of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430071, China
- cThe Agricultural Broadcasting and Television School in Hubei Province, Wuhan, 430064, China
- dKey Laboratory of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430071, China. Electronic address: sjxiaozhang@mail.hzau.edu.cn
- ✉Corresponding author
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Abstract
Bacterial infection in the mammary gland parenchyma induces local and subsequently systemic inflammation that results in a complex disease. Mastitis in bovine is the result of various factors which function together. This review is aimed to analyze the factors involved in the pathogenesis of common bacterial species for bovine mastitis. The bacterial growth patterns, signaling pathway and the pathogen-associated molecular patterns (PAMPs) which activate immune responses is discussed. Clear differences in bacterial infection pattern are shown between bacterial species and illustrated TLRs, NLRs and RLGs molecular mechanism for the initiation of intramammary infection. The underlying reasons for the differences and the resulting host response are analyzed. Understandings of the mechanisms that activate and regulate these responses are central to the development of efficient anticipatory and treatment management. The knowledge of bovine mammary gland to common mastitis causing pathogens with possible immune mechanism could be a new conceptual understanding for the prospect of mastitis control program.
TL;DRThe knowledge of bovine mammary gland to common mastitis causing pathogens with possible immune mechanism could be a new conceptual understanding for the prospect of mastitis control program. (Semantic Scholar)