Autoamputation and Polyneuropathy in Mixed Connective Tissue Disorder: A Case Report
Syeda Naqvia b c d, Vikash Taliba b c d e, Razia Aijaza b c d f, Zeeshan Alia b c d g, Shehroz Bashira b c d h, Syed Masroor Ahmada b c d i, Shabnam Naveeda b c d j
- aJinnah Postgraduate Medical Centre, Jinnah Sindh Medical University (SMC)
- bAccident & Emergency, Jinnah Sindh Medical University (SMC)
- cInternal Medicine, Jinnah Sindh Medical University (SMC)
- dMedicine Unit 7, Jinnah Sindh Medical University (SMC)
- eAccident & Emergency, Jinnah Postgraduate Medical Center Karachi Pakistan
- fInternal Medicine, Jinnah Postgraduate Medical Center Karachi Pakistan
- gJinnah Postgrduate Medical Centre, Jinnah Sindh Medical University (SMC)
- hMedicine Unit 7, Jinnah Postgraduate Medical Center Karachi Pakistan
- iMedicine, Jinnah Postgraduate Medical Centre Karachi Pakistan
- jDepartment of Medicine, Jinnah Postgraduate Medical Center Karachi Pakistan
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Abstract
Mixed connective tissue disorder (MCTD) is a multisystem disease with overlapping features of other autoimmune diseases, such as systemic lupus erythematosus (SLE), myositis, rheumatoid arthritis, and scleroderma. MCTD presents with a distinctive antibody in serum known as U1-ribonucleoprotein (RNP). MCTD is quite rare as compared to other connective tissue disorders like SLE, systemic sclerosis, dermatomyositis, and polymyositis. We describe a case of MCTD in a young Asian female of 30 year old. This case highlights rare co-existence of polyneuropathy and autoamputation in MCTD disorder. Trigeminal neuralgia and cranial nerve involvements have been previously reported in MCTD but the findings of polyneuropathy and autoamputation are extremely rare.
TL;DRA case of MCTD in a young Asian female of 30 year old is described, highlighting rare co-existence of polyneuropathy and autoamputation in MCTd disorder. (Semantic Scholar)