Association of MAP4K4 gene single nucleotide polymorphism with mastitis and milk traits in Chinese Holstein cattle
Dinesh Bhattaraia b, Xing Chena b, Zia Ur Rehmana b, Xingjie Haoa b, Farman Ullaha b, Rahim Dada b, Hira Sajjad Talpura b, Ishwari Kadariyaa b, Lu Cuia b, Mingxia Fanc d, Shujun Zhanga b✉
- aKey Laboratory of Agricultural Animal Genetics,Breeding and Reproduction,Education Ministry of China,College of Animal Science and Technology,Huazhong Agricultural University,Wuhan 430070,People's Republic of China
- bKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Education Ministry of China, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China
- cRenmin Hospital of Wuhan University,Wuhan 430060,People's Republic of China
- dRenmin Hospital of Wuhan University, Wuhan 430060, People's Republic of China
- ✉Corresponding author
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Abstract
The objective of the studies presented in this Research Communication was to investigate the association of single nucleotide polymorphisms present in the MAP4K4 gene with different milk traits in dairy cows. Based on previous QTL fine mapping results on bovine chromosome 11, the MAP4K4 gene was selected as a candidate gene to evaluate its effect on somatic cell count and milk traits in ChineseHolstein cows. Milk production traits including milk yield, fat percentage, and protein percentage of each cow were collected using 305 d lactation records. Association between MAP4K4 genotype and different traits and Somatic Cell Score (SCS) was performed using General Linear Regression Model of R. Two SNPs at exon 18 (c.2061T > G and c.2196T > C) with genotype TT in both SNPs were found significantly higher for somatic SCS. We found the significant effect of exon 18 (c.2061T > G) on protein percentage, milk yield and SCS. We identified SNPs at different location of MAP4K4 gene of the cattle and several of them were significantly associated with the somatic cell score and other different milk traits. Thus, MAP4K4 gene could be a useful candidate gene for selection of dairy cattle against mastitis and the identified polymorphisms might potentially be strong genetic markers.
TL;DRMAP4K4 gene could be a useful candidate gene for selection of dairy cattle against mastitis and the identified polymorphisms might potentially be strong genetic markers. (Semantic Scholar)