Pneumococcal polysaccharide immunization of children with sickle cell disease. I. Clinical reactions to immunization and relationship to preimmunization antibody.
G. Overturf, J. Rigau-Pérez, J. Selzer, R. Field, D. Powars, E. J. Pang, C. Uy, G. Honig, J. Weiss, L. Chan, B. Portnoy
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Abstract
Vaccine reaction data were obtained from 154 patients with sickle cell disease immunized with tetradecavalent pneumococcal polysaccharide vaccine. There was a high rate (70%) of mild reactions, primarily at the site of injection. Fever over 100 degrees F was uncommon and precipitation of symptoms similar to sickling crisis was rare. Development of local reactions was associated with the level of preimmunization pneumococcal antibody titer.
TL;DRDevelopment of local reactions was associated with the level of preimmunization pneumococcal antibody titer, and there was a high rate (70%) of mild reactions, primarily at the site of injection. (Semantic Scholar)