Relevance of Non-communicable Comorbidities for the Development of the Severe Forms of Dengue: A Systematic Literature Review
João Toledoa✉, Leyanna Susan Georgeb✉, Eric Martinezc✉, Adhara Lazarod✉, Wai Wai Hane✉, Giovanini Evelim Coelhof✉, Silvia Runge Ranzingerg✉, Olaf Horstickh✉
- aConsultant in Public Health, Ministry of Health, Brasilia, Brazil
- bDepartment of Community Medicine, Amrita School of Medicine, Amrita Vishwa Vidyapeetham University, Kochi, India
- cInstituto Pedro Kouri, La Habana, Cuba
- dConsultant in Public Health, Institute of Public Health, University of Heidelberg, Heidelberg, Germany
- eMinistry of Health, Rangoon, Myanmar
- fCoordinator of the Brazilian Dengue Programme, Ministry of Health, Brasilia, Brazil
- gConsultant in Public Health, Ludwigsburg, Institute of Public Health, University of Heidelberg, Heidelberg, Germany
- hInstitute of Public Health, University of Heidelberg, Heidelberg, Germany
- ✉Corresponding author
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Abstract
Patients with dengue fever and comorbidities seem to be at higher risk of developing complications and/or severe dengue compared to healthier individuals. This study systematically reviews the evidence related to comorbidities and dengue. A systematic literature review was performed in five databases (EMBASE, PUBMED, Global Health, SciELO, Cochrane) and grey literature for full-text articles since its inceptions until October 10, 2015. A total of 230 articles were retrieved. Sixteen studies were analysed after applying all inclusion and exclusion criteria. Seven case control studies and nine retrospective cohort studies showed that comorbidities may contribute to severe dengue, especially 1) cardiovascular disease, 2) stroke, 3) diabetes, 4) respiratory disease and 5) renal disease, as well as old age. However, due to heterogeneity in studies, the real estimate effect of comorbidities as modifiers of dengue severity could not be established. Further research in regions with high prevalence of dengue infection would contribute to a better understanding of the relevance of comorbidities in severe dengue, especially with a standardised protocol, for outcomes, specific comorbidities, study design-best using prospective designs-and sample sizes.
TL;DRIt is shown that comorbidities may contribute to severe dengue, especially 1) cardiovascular disease, 2) stroke, 3) diabetes, 4) respiratory disease and 5) renal disease, as well as old age, however, due to heterogeneity in studies, the real estimate effect of com orbidities as modifiers of dengu severity could not be established. (Semantic Scholar)