Possible role of male factors in recurrent pregnancy loss.
Pikee Saxenaa b, Man Mohan Misro, Somnath Roy, Kusum Chopra, Devabrata Sinha, Deoki Nandan, Shubha Sagar Trivedi
- aDepartment of Obstetrics and Gynecology, Lady Hardinge Medical College and Shrimati Sucheta Kriplani Hospital, New Delhi 110 001. pikeesaxena@hotmail.com
- bDepartment of Obstetrics and Gynecology, Lady Hardinge Medical College and Shrimati Sucheta Kriplani Hospital, New Delhi 110 001
Papers open inside SciRah from the original publisher or repository; SciRah never hosts them.
Abstract
OBJECTIVE: To evaluate various causes possibly contributing towards recurrent pregnancy loss (RPL), particularly male factors. Prospective study of 75 couples with history of RPL who were investigated for genetic, anatomic, immunological, infective and systemic causes in both partners. Functional sperm capacity was assessed by the Hypo-osmotic swelling test (HOS), Acrosomal Reaction (AR), Nuclear condensation-decondensation test (NCD) and Seminal Total Leukocyte Count (TLC) along with semen analysis. Twenty male volunteers with recently proven fertility were also included for detailed sperm morphology and sperm functions test as controls. Amongst male partners 3 (4%) had varicocele, 23 (30.6%) had infection, 1 (1.3%) immunological and 1 (1.3%) had genetic abnormality. Sperm motility, viability and sperm function tests were significantly lower in the RPL group as compared to the control group (P = 0.000). Male factor might be a possible contributing factor towards RPL. Both the partners should be evaluated and treated simultaneously in order to achieve desirable outcome.
TL;DRSperm motility, viability and sperm function tests were significantly lower in the RPL group as compared to the control group (P = 0.000), suggesting male factor might be a possible contributing factor towards RPL. (Semantic Scholar)