Secondary heterologous dengue infection risk: Disequilibrium between immune regulation and inflammation?
Beatríz Sierraa b✉, Ana B. Perezb, Katrin Vogtc d, Gissel Garcı́ab, Kathrin Schmolkec d, Eglys Aguirreb, Mayling Álvarezb, Florian Kernc d, Gustavo Kouríb, Hans‐Dieter Volkc d, María G. Guzmánb
- aCellular Immunology Lab, Virology Department, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, Institute of Tropical Medicine, Pedro Kouri Autopista Novia del Mediodia, La Lisa, Ciudad Habana, Cuba. siebet@ipk.sld.cu
- bVirology Department, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, Institute of Tropical Medicine, “Pedro Kouri” Autopista Novia del Mediodia, Km 6[1/2], La Lisa, Habana, Cuba
- cInstitute for Medical Immunology, Charité-Universitätsmedizin Berlin, CCM, Charitéplatz 1,D-10117 Berlin, Germany
- dInstitute for Medical Immunology, Charité-Universitätsmedizin Berlin, CCM, Charitéplatz 1, D-10117 Berlin, Germany
- ✉Corresponding author
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Abstract
Increased serum levels of cytokines released by cells of the immune response have been detected in patients suffering from dengue disease. Likewise, secondary infections by a different dengue virus serotype result in a highest risk of development of the severe dengue disease. Both findings suggest that the memory immune response is one of the key players in the pathogenesis of this disease. Here we take advantage of the particular Cuban epidemiological situation in dengue to analyze a broad spectrum of cell-mediated immune response mediators at mRNA and protein level. Evidences for a regulatory immune pattern in homologous (TGF-beta, IL-10) vs. pro-inflammatory pattern (IFN-gamma, TNF-alpha) in heterologous dengue virus re-challenge were found, suggesting a possible association with the higher incidence of severe dengue cases in the latter case.
TL;DREvidences for a regulatory immune pattern in homologous (TGF-beta, IL-10) vs. pro-inflammatory pattern (IFN-gamma, TNF-alpha) in heterologous dengue virus re-challenge were found, suggesting a possible association with the higher incidence of severe d Dengue cases in the latter case. (Semantic Scholar)