Emergence and Global Spread of a Dengue Serotype 3, Subtype III Virus
William B. Messera b✉, Duane J. Gublerc, Eva Harrisd, Kamalanayani Sivananthane, Aravinda M. de Silvaa b✉
- aUniversity of North Carolina, Chapel Hill, North Carolina, USA
- bUniversity of North CarolinaChapel Hill, North Carolina, USA
- cCenters for Disease Control and Prevention, Fort Collins, Colorado, USA
- dUniversity of California, Berkeley, California, USA
- eMedical Research Institute, Colombo, Sri Lanka
- ✉Corresponding author
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Abstract
Over the past two decades, dengue virus serotype 3 (DENV-3) has caused unexpected epidemics of dengue hemorrhagic fever (DHF) in Sri Lanka, East Africa, and Latin America. We used a phylogenetic approach to evaluate the roles of virus evolution and transport in the emergence of these outbreaks. Isolates from these geographically distant epidemics are closely related and belong to DENV-3, subtype III, which originated in the Indian subcontinent. The emergence of DHF in Sri Lanka in 1989 correlated with the appearance there of a new DENV-3, subtype III variant. This variant likely spread from the Indian subcontinent into Africa in the 1980s and from Africa into Latin America in the mid-1990s. DENV-3, subtype III isolates from mild and severe disease outbreaks formed genetically distinct groups, which suggests a role for viral genetics in DHF.
TL;DRDENV-3, subtype III isolates from mild and severe disease outbreaks formed genetically distinct groups, which suggests a role for viral genetics in DHF. (Semantic Scholar)