Comparative Functional Genomics of the Fission Yeasts
Nick Rhinda✉, Zehua Chenb, Moran Yassourc d e✉, Dawn Anne Thompsonc✉, Brian J. Haasb✉, Naomi Habibe f✉, Ilan N. Wapinskic g✉, Sushmita Royc h✉, Michael F. Linh, David I. Heimanb, Sarah Youngb, Kanji Furuyai, Yabin Guoj, Alison L. Pidouxk, Huei Mei Chenl, Barbara Robbertsem, Jonathan M. Goldbergb, Keita Aokii, Elizabeth H. Baynek, Aaron M. Berlinb, Christopher A. Desjardinsb, Edward Dobbsk, Livio Dukaja, Lin Fanb, Michael G. FitzGeraldb, Courtney E. Frenchf, Sharvari Gujjab, Klavs Hansenn, Daniel Keifenheima, Joshua Z. Levinb and 30 others
- aBiochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
- bBroad Institute of Massachusetts Institute of Technology and Harvard, 320 Charles Street, Cambridge, MA 02141, USA
- cBroad Institute of Massachusetts Institute of Technology and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
- dDepartment of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
- eSchool of Computer Science and Engineering, Hebrew University, Jerusalem 91904, Israel
- fDepartment of Microbiology and Molecular Genetics, Faculty of Medicine, Hebrew University, Jerusalem 91120, Israel
- gDepartment of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Alpert 536, Boston, MA 02115, USA
- hComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street 32-D510, Cambridge, MA 02139, USA
- i
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Abstract
The fission yeast clade--comprising Schizosaccharomyces pombe, S. octosporus, S. cryophilus, and S. japonicus--occupies the basal branch of Ascomycete fungi and is an important model of eukaryote biology. A comparative annotation of these genomes identified a near extinction of transposons and the associated innovation of transposon-free centromeres. Expression analysis established that meiotic genes are subject to antisense transcription during vegetative growth, which suggests a mechanism for their tight regulation. In addition, trans-acting regulators control new genes within the context of expanded functional modules for meiosis and stress response. Differences in gene content and regulation also explain why, unlike the budding yeast of Saccharomycotina, fission yeasts cannot use ethanol as a primary carbon source. These analyses elucidate the genome structure and gene regulation of fission yeast and provide tools for investigation across the Schizosaccharomyces clade.
TL;DRDifferences in gene content and regulation explain why, unlike the budding yeast of Saccharomycotina, fission yeasts cannot use ethanol as a primary carbon source and provide tools for investigation across the Schizosaccharomyces clade. (Semantic Scholar)